Magnesium metabolism

Walser, Mackenzie

doi:10.1007/bfb0115466

Cited by 31 publications

(39 citation statements)

References 559 publications

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“…In agreement with previous studies (Alfrey et al, 1974;Ralston et al, 1989;Walser, 1967), this study demonstrated the lack of correlation between plasma and intracellular Mg2+ levels, indicating the difficulties in interpretation of plasma levels. The intracellular Mg2+ levels measured are the free levels, in contrast to total Mg2+ levels detemined by previous techniques (Elin & Hosseini, 1985).…”

Section: Discussionsupporting

confidence: 92%

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Intracellular free magnesium in lymphocytes from patients with congestive cardiac failure treated with loop diuretics with and without amiloride.

Garrido

Davies

et al. 1992

Brit J Clinical Pharma

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Cellular Mg2+ depletion has been reported in patients on long term diuretic therapy. We therefore measured lymphocyte free Mg2+ concentrations in patients with congestive cardiac failure treated with loop diuretics or a frusemide/amiloride mixture (Frumil) and compared them with control subjects. There was no correlation between lymphocyte free Mg2+ levels and plasma Mg2+ concentrations. Patients treated with loop diuretics did not show lymphocyte intracellular free Mg2+ depletion compared with normal controls, and those on Frumil showed higher intracellular free Mg2+ levels than normal.

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Section: Discussionsupporting

confidence: 92%

“…The assessment of Mg2+ status using less invasive techniques has been difficult because of the lack of correlation between plasma or erythrocyte Mg2+ levels and levels in other tissues (Alfrey et al, 1974;Walser, 1967).…”

Section: Introduction Amiloride Methodsmentioning

confidence: 99%

Intracellular free magnesium in lymphocytes from patients with congestive cardiac failure treated with loop diuretics with and without amiloride.

Garrido

Davies

et al. 1992

Brit J Clinical Pharma

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“…no alteration in the readings of the electrodes when inserted more deeply into the impaled cells (c.f. Alvarez-Leefmans et al 1984), and (ii) the relatively high myoplasmic mobility of Na+, K+ and Mg2+ (Kushmerick & Podolsky, 1969;Edzes & Berendsen, 1975;Maughan, 1983) (Walser, 1967;Flatman, 1984) (Gilbert, 1960;Flatman, 1984).…”

Section: Discussionmentioning

confidence: 99%

Intracellular free magnesium in frog skeletal muscle fibres measured with ion‐selective micro‐electrodes.

Álvarez-Leefmans¹,

Gamiño²,

Giráldez³

et al. 1986

The Journal of Physiology

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SUMMARY1. Intracellular free Mg2+ concentration ([Mg2+]i) was measured in frog skeletal muscle fibres, using Mg2+-selective micro-electrodes based on the neutral ligand ETH-1117.2. In calibration solutions the electrodes showed significant interference from K+, and to a lesser extent from Na+, at concentrations found intracellularly. Therefore, in order to calibrate the electrodes properly, it was necessary first to obtain an accurate value for intracellular free Na+ and K+ concentrations ([Na+]

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“…The pivotal role that magnesium plays in many essential metabolic processes has attracted considerable investigative effort and has been the subject of recent extensive reviews [10,12]. However, comparatively little attention has been paid to magnesium metabolism during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Fetal Homeostasis in Maternal Malnutrition. II. Magnesium Deprivation

1971

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ExtractIn rats, supplied with an adequate dietary intake of magnesium, the mean fetal magnesium concentration in plasma was 2.4 mEq/liter compared with a maternal concentration of 1.6 mEq/liter. Equilibrium dialysis experiments resulted in a disappearance of the fetal to maternal gradient, with maternal levels becoming slightly higher than fetal levels. Determination of ultrafiltrable magnesium concentrations also demonstrated a slightly lower binding capacity for magnesium in fetal plasma so that the fetal to maternal gradient reflected the unbound magnesium.When a diet containing magnesium in a concentration of 0.88 mEq/kg (compared with a control diet containing 120 mEq/kg) was introduced on day 2 of gestation, only one of eight pregnant rats bore a litter to term. If the diet was introduced on day 10 of gestation, pregnancy continued until term but there was an increased resorption rate and the surviving fetuses were small, weak, and anemic. Analyses of maternal muscle for magnesium, calcium, sodium, and potassium revealed normal concentrations, even though magnesium concentrations in plasma rapidly fell to 20% of the normal level. There appeared to be a reduction in bone magnesium. The significant changes in the fetus were a reduction in magnesium levels in plasma with a disappearance of the fetal to maternal gradient and an elevation in sodium levels. Analysis of the total fetus demonstrated a reduction in magnesium and potassium and an increase in calcium concentrations. The last was also evident in the placenta. Speculation"Fetal parasitism" as a general concept appears to be. an over-simplification which can be denned with accuracy only by the study of deprivations of specific nutrients, and eventually by the interaction of such nutrients.

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Magnesium metabolism

Cited by 31 publications

References 559 publications

Intracellular free magnesium in lymphocytes from patients with congestive cardiac failure treated with loop diuretics with and without amiloride.

Intracellular free magnesium in lymphocytes from patients with congestive cardiac failure treated with loop diuretics with and without amiloride.

Intracellular free magnesium in frog skeletal muscle fibres measured with ion‐selective micro‐electrodes.

Fetal Homeostasis in Maternal Malnutrition. II. Magnesium Deprivation

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