Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults

He, Ka; Liu, Kiang; Daviglus, Martha L.; Morris, Steven; Loria, Catherine M.; Horn, Linda Van; Jacobs, David R.; Savage, Peter J.

doi:10.1161/circulationaha.105.588327

Cited by 304 publications

(229 citation statements)

References 39 publications

(41 reference statements)

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“…Intakes below the EAR are especially prevalent among the poor, teenagers (78% of 14-to 18-year-old males and 91% of 14-to 18-year-old females), the obese, African Americans, and the elderly (81%) (4,(20)(21)(22)(23)(24). In humans, magnesium deficiency has been associated with colorectal and other cancers (25)(26)(27)(28), hypertension, osteoporosis, diabetes, and the metabolic syndrome (5,29,89). In a study of 4,035 men followed for 18 years, the highest quartile with serum magnesium at baseline compared with the lowest had a 40% decrease in allcause mortality and cardiovascular disease and a 50% decrease in cancer deaths (30).…”

Section: Micronutrient Deficiencies May Accelerate Mitochondrial Decamentioning

confidence: 99%

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage

Ames¹

2006

Proc. Natl. Acad. Sci. U.S.A.

337

231

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Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity. Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of long-term health. I hypothesize that short-term survival was achieved by allocating scarce micronutrients by triage, in part through an adjustment of the binding affinity of proteins for required micronutrients. If this hypothesis is correct, micronutrient deficiencies that trigger the triage response would accelerate cancer, aging, and neural decay but would leave critical metabolic functions, such as ATP production, intact. Evidence that micronutrient malnutrition increases late onset diseases, such as cancer, is discussed. A multivitamin-mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life.

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Section: Micronutrient Deficiencies May Accelerate Mitochondrial Decamentioning

confidence: 99%

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage

Ames¹

2006

Proc. Natl. Acad. Sci. U.S.A.

337

231

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“…The hypothesis that Mg deficit in the diet would induce and/or exacerbate insulin resistance is confirmed by data, both in humans and in experimental animals, which have consistently shown dietary Mg deficiency is associated to insulin resistance [37][38][39][40][41][42][43]. Mgdeficient diet in sheep cause a significant impairment of insulinmediated glucose uptake [38] and Mg supplementation delayed the development of diabetes in a rat model of diabetes [39].…”

Section: Dietary Mg Deficiency May Predispose To Insulin Resistance Amentioning

confidence: 96%

“…Two meta-analyses of prospective studies concluded that Mg intake is inversely associated with type 2 diabetes [49,50]. Mg intake has been also strongly and inversely associated with the metabolic syndrome [37,51], while hypomagnesaemia has been independently associated with the development of impaired glucose tolerance [52]. Increased Mg intake is associated with increased insulin sensitivity [53] and a decreased risk of developing type 2 diabetes [54,55].…”

Section: Issn: 2377-3634mentioning

confidence: 99%

Magnesium and Type 2 Diabetes: An Update

Barbagallo¹

2015

Int J Diabetes Clin Res

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The link between magnesium (Mg) deficiency and type 2 diabetes mellitus is well known. Type 2 diabetes is frequently associated with both extracellular and intracellular Mg deficits. A chronic latent Mg deficit or an overt clinical hypomagnesaemia is common in subjects with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistance in diabetic patients. A low Mg intake and an increased Mg urinary loss appear the most important mechanisms that may favor Mg depletion in patients with type 2 diabetes. Low dietary Mg intake has been related to the development of type 2 diabetes and metabolic syndrome. Benefits of Mg supplementation on metabolic profile in diabetic subjects have been found in most, but not all clinical studies and larger prospective studies are needed to support the potential role of dietary Mg supplementation as a possible public health strategy in diabetes risk.The objective of this review is to revise current evidences on the mechanisms of Mg deficiency in diabetes mellitus type 2 and on the possible role of Mg supplementation in the prevention and management of the disease.

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“…Additionally, calcium intake was below the recommendation in both groups. Observational studies confirm that the diet rich in potassium, magnesium, and calcium is associated with lower incidence and mortality due to cardiovascular diseases 49 making calcium one of the most important minerals for individuals with cardiovascular complications like Cd patients.…”

Section: Dietary Adequacy Of Minerals (% Of Ear)mentioning

confidence: 99%

Diet Quality of patients with chronic Chagas disease in a tertiary hospital: a case-control study

Castilhos

Huguenin

Rodrigues

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Nutritional status has been implicated in the modulation of the immune response, possibly augmenting the pathogenesis of Chagas disease (Cd). We evaluated diet quality and nutritional status in adults and elderly patients with chronic Cd in a tertiary hospital. Methods: A case-control study of Cd patients was conducted, paired for gender, age, and co-morbidities with non-Cd patients. Anthropometric measurements and food frequency questionnaire was used, and diet quality was assessed by the Brazilian Healthy Eating Index-Revised (BHEI-R). The Estimated Average Requirement cut-off points were used to determine the dietary micronutrient adequacy. The Cd group was further grouped according to Los Andes classification. Results: The study participants were 67 ± 10 years old, 73.6% elderly and 63% female. The prevalence of overweight/obesity and abdominal fat was high in both groups; however, Cd group showed a lower prevalence of obesity and increased risk of disease according to waist circumference classification. There was no difference in BHEI-R score between groups (p=0.145). The Cd group had sodium and saturated fat intake above recommendations and low intake of unsaturated fat, vitamin D, E, selenium, magnesium, and dairy products; but higher intake of iron. According to Los Andes classification, group III presented lower intake of whole fruit and dietary fiber. Conclusions: Patients with Cd were overweight and the quality of their diet was unsatisfactory based on the recommended diet components for age and sex.

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Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults

Cited by 304 publications

References 39 publications

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage

Magnesium and Type 2 Diabetes: An Update

Diet Quality of patients with chronic Chagas disease in a tertiary hospital: a case-control study

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