Magnesium in Pain Research: State of the Art

Srebro, Dragana; Vučković, Sonja; Milovanović, Aleksandar; Košutić, Jovan; Vujović, Katarina Savić; Prostran, Milica

doi:10.2174/0929867323666161213101744

Cited by 39 publications

(18 citation statements)

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“…Also, it is important to note that the systemic anti-edematous doses of magnesium sulfate used in the current study correspond to the human dose used for magnesium supplementation (350 mg/day; Tolerable Upper Intake Level), or are slightly above it, and human equivalent doses are between 1 and 6 mg/kg of body weight. 6 The doses of magnesium sulfate used in the present study do not affect motor coordination, 5 do not change the serum concentration of magnesium above the reference range, 7 and do not cause a toxic increase in plasma magnesium concentration (above 3 mM). 19 Also, hypomagnesemia is associated with the onset of inflammation or can worsen it.…”

Section: Discussionmentioning

confidence: 58%

“…2 Magnesium is an interesting target for research since it is well known that a deficit of magnesium causes and worsens inflammation 3 and new research has shown that magnesium as a single drug and in a single dose has an analgesic effect in somatic and visceral inflammatory pain. [4][5][6][7] Recently published results show that magnesium sulfate reduced vasogenic edema formation in a rat model of acute ischemic stroke, partly via antioxidant mechanisms. 8 In patients with diabetic retinopathy a higher physiological range of magnesium in the serum was associated with a lower risk of diabetic macular edema.…”

Section: Introductionmentioning

confidence: 99%

“…For magnesium sulfate, the doses were selected to correspond to doses used for magnesium supplementation in humans, 6 and the next steps were adjusted based to the results obtained from the previous experiment. 4,6 The possible mechanism of action of prophylactic magnesium sulfate was investigated through the interaction between magnesium sulfate and NO precursor and/or inhibitors using the following protocols:…”

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confidence: 99%

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Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production

et al. 2023

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Background Magnesium is an antagonist of the N-methyl-D-aspartate receptor. This study aimed to investigate the anti-edematous effect of magnesium sulfate (MS) in different protocols of use and the possible mechanism of its action. Methods In a rat model of carrageenan-induced paw inflammation, the anti-edematous activity of MS was assessed with a plethysmometer. The effects of the nonselective inhibitor (L-NAME), selective inhibitor of neuronal (L-NPA) and inducible (SMT) nitric oxide synthase on the effects of MS were evaluated. Results MS administered systemically before or after inflammation reduced edema by 30% (5 mg/kg, P < .05) and 55% (30 mg/kg, P < .05). MS administered locally (.5 mg/paw, P < .05) significantly prevented the development of inflammatory edema by 60%. L-NAME, intraperitoneally administered before MS, potentiated (5 mg/kg, P < .05) or reduced (3 mg/kg, P < .05), while in the highest tested dose L-NPA (2 mg/kg, P < .01) and SMT (.015 mg/kg, P < .01) reduced the anti-edematous effect of MS. Conclusions Magnesium is a more effective anti-edematous drug in therapy than for preventing inflammatory edema. The effect of MS is achieved after systemic and local peripheral administration and when MS is administered as a single drug in a single dose. This effect is mediated at least in part via the production of nitric oxide.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production

et al. 2023

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“…Besides preventing eclamptic seizures and having cardiovascular effects, a new role for this drug in anesthesia has been defined in recent years (28)(29)(30). The antinociceptive effects of magnesium in managing acute and chronic pain have been established in numerous studies (31)(32)(33). Although the basic mechanism is not yet clear, it has been suggested that N-methyl-D-aspartate (NMDA) receptors may play a role in magnesium analgesic action.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Oral Magnesium Sachet on the Prevention of Spinal Anesthesia-Induced Headache After Cesarean Section: A Randomized Clinical Trial

et al. 2022

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Background: Post-dural puncture headache (PDPH) is a common complication of spinal anesthesia. It often goes away after a few days but may be more severe in some patients and persists for weeks. Objectives: This study aimed to evaluate the effect of oral magnesium on the prevention of PDPH after cesarean section for the first time. Methods: In this double-blind, randomized clinical trial, 100 candidates for elective cesarean section under spinal anesthesia were randomly divided into 2 groups: (i) the intervention group that received 300 mg of oral magnesium powder and (ii) the control group that received starch powder. The frequency and severity of headache and amount of analgesic consumption in both groups were measured 1, 2, and 3 days after cesarean section. Data were analyzed using SPSS version 22 at 95% CI. Results: The frequency of PDPH 1, 2, and 3 days after surgery was 8% vs 24% (P = 0.029), 10% vs 26% (P = 0.039), and 12% vs 18% (P = 0.401) in the intervention and control groups, respectively. The mean and SD of pain severity was 0.52 ± 1.83 vs 1.5 ± 2.84 (P = 0.03) on the first day, 0.70 ± 2.19 vs 1.58 ± 2.86 (P = 0.05) on the second day, and 0.82 ± 2.32 vs 1.18 ± 2.62 on the third day (P = 0.43) in the intervention and control groups, respectively. Although more patients in the control group received rescue analgesia, no significant difference was seen between the 2 study groups. Conclusions: In women candidates for cesarean section, oral administration of 300 mg magnesium 2 hours before surgery significantly reduces the frequency and severity of PDPH, but its impact on reducing analgesic consumption is not significant.

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“…Magnesium sulfate is a small colorless crystal usually used as an anticonvulsant. Additionally, as an antagonist of N-methyl-Daspartate (NMDA) receptor, magnesium can modulate pain perception by blocking the nerve system activities that depend on NMDA and achieve the chondrocyte protective effects via decreasing the superfluous entry of extracellular calcium into cells (Srebro et al, 2017). Magnesium sulfate exerts systemic and local immune modulatory effects, potentially relieving the inflammatory pain.…”

Section: Agents For Ia Injection or Intramuscular Injection Magnesium Sulfatementioning

confidence: 99%

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.

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Magnesium in Pain Research: State of the Art

Cited by 39 publications

References 0 publications

Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production

Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production

Evaluation of the Effects of Oral Magnesium Sachet on the Prevention of Spinal Anesthesia-Induced Headache After Cesarean Section: A Randomized Clinical Trial

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

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