Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes

Piuri, Gabriele; Zocchi, Monica; Porta, Matteo Della; Ficara, Valentina; Manoni, Michele; Zuccotti, Gian Vincenzo; Pinotti, L.; Maier, Jeanette A. M.; Cazzola, Roberta

doi:10.3390/nu13020320

Cited by 122 publications

(115 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The potential lipid-lowering effects of Mg warrant further investigation, with a myriad of studies linking the serum concentrations of this micronutrient to cardiometabolic disorders, e.g., obesity, T2DM, MetS, cardiovascular disorders, neurological ailments, and even cancer, all of which are worldwide public health threats [ 5 , 135 , 136 ]. Mg supplements stand out as one of the most popular supplements in Europe and the United States [ 137 ].…”

Section: Discussionmentioning

confidence: 99%

“…Magnesium (Mg) seems to play a key role in a myriad of disorders, e.g., MetS, T2DM, obesity, hypertension, and its deficiency has been regarded as highly prevalent, with Piuri et al (2021) ranking it as the most common electrolyte imbalance in high-income countries [ 4 , 5 , 6 ]. Taking this information into consideration, we may hypothesize that there is a crosstalk between Mg and serum lipids which may impact on the pathogenesis of dyslipidemia and its associated comorbidities, as well as that Mg supplementation might provide health benefits in patients suffering from cardiometabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Dyslipidemia is a significant threat to public health worldwide and the identification of its pathogenic mechanisms, as well as novel lipid-lowering agents, are warranted. Magnesium (Mg) is a key element to human health and its deficiency has been linked to the development of lipid abnormalities and related disorders, such as the metabolic syndrome, type 2 diabetes mellitus, or cardiovascular disease. In this review, we explored the associations of Mg (dietary intake, Mg concentrations in the body) and the lipid profile, as well as the impact of Mg supplementation on serum lipids. A systematic search was computed in PubMed/MEDLINE and the Cochrane Library and 3649 potentially relevant papers were detected and screened (n = 3364 following the removal of duplicates). After the removal of irrelevant manuscripts based on the screening of their titles and abstracts (n = 3037), we examined the full-texts of 327 original papers. Finally, after we applied the exclusion and inclusion criteria, a number of 124 original articles were included in this review. Overall, the data analyzed in this review point out an association of Mg concentrations in the body with serum lipids in dyslipidemia and related disorders. However, further research is warranted to clarify whether a higher intake of Mg from the diet or via supplements can influence the lipid profile and exert lipid-lowering actions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The recommended Mg intake might positively affect the composition of the intestinal microbiota and, consequently, the metabolism of the host, thus helping to prevent metabolic alterations associated with the development of metabolic syndrome and type 2 diabetes [80]. However, to improve our understanding of the effects of dietary Mg content on the human gut microbiome, we need additional clinical trials.…”

Section: Interaction Between Magnesium and Intestinal Microbiotamentioning

confidence: 99%

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Bielik

Kolísek

2021

IJMS

View full text Add to dashboard Cite

Adequate amounts of a wide range of micronutrients are needed by body tissues to maintain health. Dietary intake must be sufficient to meet these micronutrient requirements. Mineral deficiency does not seem to be the result of a physically active life or of athletic training but is more likely to arise from disturbances in the quality and quantity of ingested food. The lack of some minerals in the body appears to be symbolic of the modern era reflecting either the excessive intake of empty calories or a negative energy balance from drastic weight-loss diets. Several animal studies provide convincing evidence for an association between dietary micronutrient availability and microbial composition in the gut. However, the influence of human gut microbiota on the bioaccessibility and bioavailability of trace elements in human food has rarely been studied. Bacteria play a role by effecting mineral bioavailability and bioaccessibility, which are further increased through the fermentation of cereals and the soaking and germination of crops. Moreover, probiotics have a positive effect on iron, calcium, selenium, and zinc in relation to gut microbiome composition and metabolism. The current literature reveals the beneficial effects of bacteria on mineral bioaccessibility and bioavailability in supporting both the human gut microbiome and overall health. This review focuses on interactions between the gut microbiota and several minerals in sport nutrition, as related to a physically active lifestyle.

show abstract

“…[ 4 ] This distribution of Mg 2+ results in blood magnesium concentration being an inaccurate determinant of total body magnesium [ 5 , 6 ]. Subsequently, most Mg 2+ deficiency (hypomagnesemia—defined as ˂0.75 mmol/L) [ 7 ] goes undiagnosed [ 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium

Case

Zubieta

Gonzalez³

et al. 2021

Molecules

View full text Add to dashboard Cite

Magnesium (Mg2+) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble magnesium supplements. To this end, triglycine (HG3), a tripeptide of the amino acid glycine, was chosen as a chelating ligand for magnesium, given its natural occurrence and water solubility, and entropically-driven metal binding. Herein, we discuss the synthesis, chemical and physical characterization, and cellular uptake of a magnesium triglycine chelate (MgG3), an octahedral complex with extraordinary water solubility and improved cellular uptake in CaCo-2 cells than select commonly used magnesium supplements.

show abstract

Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes

Cited by 122 publications

References 132 publications

Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review

Crosstalk of Magnesium and Serum Lipids in Dyslipidemia and Associated Disorders: A Systematic Review

Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium

Contact Info

Product

Resources

About