Magnesium implant alloy with low levels of strontium and calcium: The third element effect and phase selection improve bio-corrosion resistance and mechanical performance

Bornapour, Mosayeb; Çelikin, Mert; Cerruti, Marta; Pekguleryuz, Mihriban

doi:10.1016/j.msec.2013.11.011

Cited by 80 publications

(45 citation statements)

References 69 publications

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“…5), careful selection of Sr content in the Mg-Sr alloy is still an important consideration when applied as a load bearing material. Although the mechanical properties could be enhanced due to continued precipitation hardening, the amount of cathodic Mg 17 Sr 2 intermetallic phases could accelerate corrosion by forming microgalvanic couples with the α-Mg matrix [51,52]. Furthermore, the adsorption of organic materials, such as proteins, into the corrosion layer has been reported to have a protective effect on the surface of Mg alloys [47,53].…”

Section: Discussionmentioning

confidence: 99%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloyIn: Acta Biomaterialia (2015) Elsevier DOI: 10.1016DOI: 10. /j.actbio.2015 An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloy AbstractPrevious studies indicated that local delivery of strontium effectively increased bone quality and formation around osseointegrating implants. Therefore, implant materials with long-lasting and controllable strontium release are avidly pursued. The central objective of the present study was to investigate the in vivo biocompatibility, metabolism and osteogenic activity of the bioabsorbable Mg-1Sr (wt.%, nominal composition) alloy for bone regeneration. The general corrosion rate of the alloy implant as a femoral fracture fixation device was 0.55 ± 0.03 mm y −1 (mean value ± standard deviation) in New Zealand White rabbits which meet the bone implantation requirements and can be adjusted by material processing methods. All rabbits survived and the histological evaluation showed no abnormal physiology or diseases 16 weeks post-implantation. The degradation process of the alloy did not significantly alter 16 primary indexes of hematology, cardiac damage, inflammation, hepatic functions and metabolic process. Significant increases in peri-implant bone volume and direct bone-toimplant contact (48.3% ± 15.3% and 15.9% ± 5.6%, respectively) as well as the expressions of four osteogenesis related genes (runt-related transcription factor 2, alkaline phosphatase, osteocalcin, and collagen, type I, alpha 1) were observed after 16 weeks implantation for the Mg-1Sr group when compared to the pure Mg group. The sound osteogenic properties of the Mg-1Sr alloy by longlasting and controllable Sr release suggesting a very attractive clinical potential. Statement of significanceSr (strontium) has exhibited pronounced effects to reduce the bone fracture risk in osteoporotic patients. Nonetheless, long-lasting local Sr release is hardly achieved by traditional methods like surface treatment. Therefore, a more efficient Sr local delivery platform is in high clinical demand. The stable and adjustable degradation process of Mg alloy makes it an ideal Sr delivery platform. We combine the well-known osteogenic properties of strontium with magnesium to manufacture bioabsorbable Mg-1Sr alloy with stable Sr release based on our previous studies. The in vitro and in vivo results both showed the alloy's suitable degradation rate and biocompatibility, and the sound osteogenic properties and stimulation effect on bone formation suggest its very attractive clinical potential.

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Section: Discussionmentioning

confidence: 99%

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

et al. 2016

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“…The solubility limit of Ca is however only 1 wt %, after which the corrosion resistance drops due to the development of Mg 2 Ca second phases [155]. Yet Bornapour et al [156] assumed the presence of a second phase as being desirable. Comparing the corrosion behaviour of pure Mg to that of different types of alloys with Ca and Sr (Mg-0.5Sr, Mg-0.6Ca, Mg-0.5Sr-0.6Ca, Mg-0.3Sr-0.3Ca), they found that Mg-0.3Sr-0.3Ca alloys have the highest corrosion resistance, despite the presence of Ca/Sr-rich second phases ( Figure 29).…”

Section: Calciummentioning

confidence: 99%

Mg and Its Alloys for Biomedical Applications: Exploring Corrosion and Its Interplay with Mechanical Failure

Peron

Torgersen

Berto

2017

Metals

110

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Abstract:The future of biomaterial design will rely on temporary implant materials that degrade while tissues grow, releasing no toxic species during degradation and no residue after full regeneration of the targeted anatomic site. In this aspect, Mg and its alloys are receiving increasing attention because they allow both mechanical strength and biodegradability. Yet their use as biomedical implants is limited due to their poor corrosion resistance and the consequential mechanical integrity problems leading to corrosion assisted cracking. This review provides the reader with an overview of current biomaterials, their stringent mechanical and chemical requirements and the potential of Mg alloys to fulfil them. We provide insight into corrosion mechanisms of Mg and its alloys, the fundamentals and established models behind stress corrosion cracking and corrosion fatigue. We explain Mgs unique negative differential effect and approaches to describe it. Finally, we go into depth on corrosion improvements, reviewing literature on high purity Mg, on the effect of alloying elements and their tolerance levels, as well as research on surface treatments that allow to tune degradation kinetics. Bridging fundamentals aspects with current research activities in the field, this review intends to give a substantial overview for all interested readers; potential and current researchers and practitioners of the future not yet familiar with this promising material.

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“…Decreasing the metallic grain size within the material volume, either by alloying elements, SPD methods, such as extrusion, equal channel angular pressing (ECAP) and high-pressure torsion (HPT) or PM, leads to increase of hardness, tensile and yield strength, but the plasticity of the material was shown to be decreased [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Highly porous materials corrode very rapidly, as a larger area of the material surface is exposed to the corrosion environment. Corrosion resistance of either pure magnesium or magnesium alloys is seldom suitable for technical applications or even biomedical applications [3,9,[16][17][18][19][20]. Magnesium corrosion resistance can be improved by alloying the metal with aluminum, zinc or rare earth metal elements; however, for significantly better corrosion resistance, another way of reducing the degradation rate must be considered.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

Zapletal

Březina

Krystýnová

et al. 2017

Metals

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Magnesium with its mechanical properties and nontoxicity is predetermined as a material for biomedical applications; however, its high reactivity is a limiting factor for its usage. Powder metallurgy is one of the promising methods for the enhancement of material mechanical properties and, due to the introduced plastic deformation, can also have a positive influence on corrosion resistance. Pure magnesium samples were prepared via powder metallurgy. Compacting pressures from 100 MPa to 500 MPa were used for samples' preparation at room temperature and elevated temperatures. The microstructure of the obtained compacts was analyzed in terms of microscopy. The three-point bending test and microhardness testing were adopted to define the compacts' mechanical properties, discussing the results with respect to fractographic analysis. Electrochemical corrosion properties analyzed with electrochemical impedance spectroscopy carried out in HBSS (Hank's Balanced Salt Solution) and enriched HBSS were correlated with the metallographic analysis of the corrosion process. Cold compacted materials were very brittle with low strength (up to 50 MPa) and microhardness (up to 50 HV (load: 0.025 kg)) and degraded rapidly in both solutions. Hot pressed materials yielded much higher strength (up to 250 MPa) and microhardness (up to 65 HV (load: 0.025 kg)), and the electrochemical characteristics were significantly better when compared to the cold compacted samples. Temperatures of 300 • C and 400 • C and high compacting pressures from 300 MPa to 500 MPa had a positive influence on material bonding, mechanical and electrochemical properties. A compacting temperature of 500 • C had a detrimental effect on material compaction when using pressure above 200 MPa.

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Magnesium implant alloy with low levels of strontium and calcium: The third element effect and phase selection improve bio-corrosion resistance and mechanical performance

Cited by 80 publications

References 69 publications

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg–1Sr alloy

Mg and Its Alloys for Biomedical Applications: Exploring Corrosion and Its Interplay with Mechanical Failure

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

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