Magnesium, hyperactivity and autism in children

Mousain-Bosc, Marianne; Siatka, Christian; Balì, Jean-Pierre

doi:10.1017/upo9780987073051.022

Cited by 11 publications

(6 citation statements)

References 58 publications

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“…In this study, BPA was found to trigger motor abnormalities in males and females, and that co-treatment of BPA and VitD led to a significant reduce in BPA-induced motor abnormalities [45][46][47][48]. These findings are consistent with several previous reports, wherein BPA was shown to cause developmental motor abnormalities, and VitD treatment negatively correlated with the risk of motor abnormalities [49].…”

Section: Plos Onesupporting

confidence: 92%

Therapeutic potential of vitamin D against bisphenol A-induced spleen injury in Swiss albino mice

Al-Griw¹,

Balog²,

Shaibi³

et al. 2023

PLoS ONE

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Bisphenol A (BPA), a ubiquitous plasticizer, is capable of producing oxidative splenic injury, and ultimately led to spleen pathology. Further, a link between VitD levels and oxidative stress was reported. Hence the role of VitD in BPA-induced oxidative splenic injury was investigated in this study. Sixty male and female Swiss albino mice (3.5 weeks old) were randomly divided into control and treated groups 12 mice in each (six males and six females). The control groups were further divided into sham (no treatment) and vehicle (sterile corn oil), whereas the treatment group was divided into VitD (2,195 IU/kg), BPA (50 μg/kg), and BPA+VitD (50 μg/kg + 2,195 IU/kg) groups. For six weeks, the animals were dosed intraperitoneally (i.p). One week later, at 10.5 weeks old, mice were sacrificed for biochemical and histological analyses. Findings showed BPA triggered neurobehavioral abnormalities and spleen injury with increased apoptotic indices (e.g. DNA fragmentation) in both sexes. A significant increase was found in lipid peroxidation marker, MDA in splenic tissue, and leukocytosis. Conversely, VitD treatment altered this scenario into motor performance preservation, reducing oxidative splenic injury with a decrease in the percent apoptotic index. This protection was significantly correlated with preserving leukocyte counts and reduced MDA levels in both genders. It can be concluded from the above findings that VitD treatment has an ameliorative effect on oxidative splenic injury induced by BPA, highlighting the continuous crosstalk between oxidative stress and the VitD signaling pathway.

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Section: Plos Onesupporting

confidence: 92%

Therapeutic potential of vitamin D against bisphenol A-induced spleen injury in Swiss albino mice

Al-Griw¹,

Balog²,

Shaibi³

et al. 2023

PLoS ONE

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“…Moreover, magnesium deficiency has been also associated with oxidative stress [98]. In ASD patients, typically characterized by low levels of magnesium in the blood, magnesium supplementation leads to improvements of symptoms, such as poor concentration and hyperactivity [99]. In addition, it was shown that in valproic acid (VPA)-exposed dams, treatment with high doses of folic acid, vitamin E and the methyl donor methionine could ameliorate or prevent most of the VPA-induced damage [100,101].…”

Section: Targeting Ros To Treat Asdmentioning

confidence: 99%

Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders

Pangrazzi

Balasco

Bozzi

2020

IJMS

150

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Autism Spectrum Disorders (ASDs) represent a group of neurodevelopmental disorders associated with social and behavioral impairments. Although dysfunctions in several signaling pathways have been associated with ASDs, very few molecules have been identified as potentially effective drug targets in the clinic. Classically, research in the ASD field has focused on the characterization of pathways involved in neural development and synaptic plasticity, which support the pathogenesis of this group of diseases. More recently, immune system dysfunctions have been observed in ASD. In addition, high levels of reactive oxygen species (ROS), which cause oxidative stress, are present in ASD patients. In this review, we will describe the major alterations in the expression of genes coding for enzymes involved in the ROS scavenging system, in both ASD patients and ASD mouse models. In addition, we will discuss, in the context of the most recent literature, the possibility that oxidative stress, inflammation and immune system dysfunction may be connected to, and altogether support, the pathogenesis and/or severity of ASD. Finally, we will discuss the possibility of novel treatments aimed at counteracting the interplay between ROS and inflammation in people with ASD.

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“…Moreover, magnesium deficiency has also been associated with oxidative stress [103,104]. As autistic children usually have low levels of blood magnesium, magnesium supplementation leads to the amelioration of symptoms, among which are poor concentration and hyperactivity, which usually negatively affects the learning ability of the autistic children in the class [103].…”

Section: Discussionmentioning

confidence: 99%

Learning Difficulties and Oxidative Stress in Autism Spectrum Disorder: A Review of the Role of Nutritional Interventions

et al. 2021

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Although much is known about how to educate children with autism spectrum disorder (ASD), with program success strategies commonly suggested, autistic children are nevertheless at increased risk of poor academic performance. It has been documented that autistic children have significant behavioral problems that influence their learning abilities. Among these problems are poor social skills, impaired language and communication skills, hyperactivity, and repetitive behavior, making these young students at risk of poor long-term school adjustment. Based on our understanding of the etiological mechanisms of ASD, we have examined potential methods of improving the learning ability of autistic children through nutritional interventions that may relieve oxidative stress, which is one of the main etiologies of this disorder that control other contributing factors known to affect general cognition (e.g., brain inflammation and glutamate excitotoxicity). In this study, we have also examined the relationship between nutrient supplementation and the improvement of learning progress in autistic children.

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Magnesium, hyperactivity and autism in children

Cited by 11 publications

References 58 publications

Therapeutic potential of vitamin D against bisphenol A-induced spleen injury in Swiss albino mice

Therapeutic potential of vitamin D against bisphenol A-induced spleen injury in Swiss albino mice

Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders

Learning Difficulties and Oxidative Stress in Autism Spectrum Disorder: A Review of the Role of Nutritional Interventions

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