Magnesium for alcohol withdrawal

Sarai, Michael; Tejani, Aaron M; Chan, Alice; Kuo, I fan; Li, Juliana

doi:10.1002/14651858.cd008358.pub2

Cited by 27 publications

(20 citation statements)

References 59 publications

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“…9,[18][19][20] Provide medications to control agitation, promote sleep, and raise the seizure threshold.…”

Section: Discussionmentioning

confidence: 99%

“…The major treatment goals for withdrawal delirium are to control agitation, decrease the risk of seizures, and decrease the risk of injury and death with the use of the methods outlined in Table 3. 7,9,13,[18][19][20][21][22][23] Because of the high prevalence of agitation among patients with withdrawal delirium and the potential lethal outcomes, treatment is best carried out in a locked inpatient ward or an ICU.…”

Section: Components Of Scale Most Severe Manifestationsmentioning

confidence: 99%

“…18,23 Although thiamine (e.g., 500 mg infused intravenously over the course of 30 minutes once or twice daily for 3 days) and multivitamins are recommended, there is little support for routine administration of magnesium. 9,19,20,24 In patients in whom Wernicke's encephalopathy is suspected, recommended doses of thiamine are even higher (e.g., 500 mg intravenously three times daily for 5 days), in addition to daily parenteral multivitamins. 24 The mainstay of the pharmacologic treatment of withdrawal delirium is depressants such as benzodiazepines.…”

Section: Components Of Scale Most Severe Manifestationsmentioning

confidence: 99%

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Recognition and Management of Withdrawal Delirium (Delirium Tremens)

2014

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A t some time in their lives, 20% of men and 10% of women in most Western societies will have an alcohol-use disorder, which is defined as repetitive alcohol-related problems in at least 2 of 11 areas of life. 1,2 These conditions can decrease the life span by a decade and are associated with severe impairments in social functioning, as well as high rates of medical problems. Although alcohol-related conditions occur in persons from all social strata and affect more than 20% of patients in most medical settings, 2,3 few physicians have been adequately trained in identifying and treating these serious problems.About 50% of persons with alcohol-use disorders have symptoms of alcohol withdrawal when they reduce or discontinue their alcohol consumption; in 3 to 5% of these persons, grand mal convulsions, severe confusion (a delirium), or both develop. 1 It is essential that clinicians know how to prevent, recognize, and treat these severe withdrawal states to minimize costly hospitalizations and avoidable deaths.

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“…9,[18][19][20] Provide medications to control agitation, promote sleep, and raise the seizure threshold.…”

Section: Discussionmentioning

confidence: 99%

Section: Components Of Scale Most Severe Manifestationsmentioning

confidence: 99%

Section: Components Of Scale Most Severe Manifestationsmentioning

confidence: 99%

See 1 more Smart Citation

Recognition and Management of Withdrawal Delirium (Delirium Tremens)

2014

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“…Poor-quality clinical data exist regarding the efficacy of magnesium in preventing withdrawal syndrome. A recent Cochrane review was unable to generate significant recommendations in support of magnesium supplementation (52).…”

Section: Magnesiummentioning

confidence: 99%

Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU

Flannery

Adkins

Cook

2016

Critical Care Medicine

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Based on the published literature, for patients with a chronic alcohol use disorder admitted to the ICU with symptoms that may mimic or mask Wernicke's encephalopathy, we suggest abandoning the banana bag and utilizing the following formula for routine supplementation during the first day of admission: 200-500 mg IV thiamine every 8 hours, 64 mg/kg magnesium sulfate (approximately 4-5 g for most adult patients), and 400-1,000 μg IV folate. If alcoholic ketoacidosis is suspected, dextrose-containing fluids are recommended over normal saline.

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“…Aunque inicialmente se había sugerido que su administración profiláctica podría disminuir la actividad neuromuscular en estos enfermos, no se ha demostrado que esta medida tenga ningún efecto en el control de los síntomas o sobre la aparición de crisis comiciales 44 . Se recomienda su empleo únicamente en aquellos casos en los que se compruebe un déficit.…”

Section: Tiamina Y Magnesiounclassified