Magnesium enhances opioid-induced analgesia – What we have learnt in the past decades?

Bujalska‐Zadrożny, Magdalena; Tatarkiewicz, Jan; Kulik, Kamila; Filip, Małgorzata; Naruszewicz, Marek

doi:10.1016/j.ejps.2016.11.020

Cited by 41 publications

(37 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Magnesium ions inhibit NMDA receptor activation by producing voltage-dependent block of calcium ion influx through the receptor channel 1. In preclinical studies, systemically and intrathecally administered magnesium enhances opioid analgesia, especially in persistent neuropathic and inflammatory pain models 1 4.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, magnesium is known to modulate pain through inhibition of N-methyl-d-aspartate (NMDA) receptor activation,1 and its perioperative administration has been shown to enhance postoperative analgesia 2. We report the cessation of chronic regional pain syndrome (CRPS)-related pain during the treatment of preeclampsia with magnesium, and review the current evidence regarding magnesium as a possible analgesic in the treatment of CRPS-related pain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Complete relief of CRPS-associated pain during magnesium infusion in a patient with postpartum preeclampsia

Niconchuk

Richardson

2019

Regional Anesthesia &Amp; Pain Medicine

View full text Add to dashboard Cite

A pregnant patient with chronic regional pain syndrome (CRPS) and indwelling spinal cord stimulator presented with twin gestation for induction of preterm labor due to preeclampsia. Intravenous magnesium was initiated and a lumbar epidural catheter was placed uneventfully for labor analgesia. The patient reported complete relief of her CRPS-associated pain during and for 24 hours after delivery, while receiving intravenous magnesium, with her pain symptoms returning shortly after discontinuing magnesium. To our knowledge, there are no case reports that describe CRPS-associated pain relief while on peripartum magnesium therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Complete relief of CRPS-associated pain during magnesium infusion in a patient with postpartum preeclampsia

Niconchuk

Richardson

2019

Regional Anesthesia &Amp; Pain Medicine

View full text Add to dashboard Cite

show abstract

“…Literature data indicate that both ketamine and magnesium increase opioid antinociception in different animal models of pain (Begon et al 2002, Alvarez et al 2003, Savic Vujovic et al 2015, Bujalska-Zadrożny et al 2016). In addition, evidence for the involvement of endogenous opioids and mu and delta opioid receptors in ketamine-induced antinociception has been presented (Sarton et al 2001, Pacheco Dda et al 2014.…”

Section: Discussionmentioning

confidence: 99%

“…When morphine activates the mu receptor, the resulting phosphorylation of a residue of the NMDA receptor causes the dissociation of both receptors and mu receptor desensitization (Rodrigez-Munoz et al 2012). Like ketamine, magnesium is a NMDA receptor antagonist and can prevent NMDA receptor phosphorylation and opioid-induced hyperalgesia (Bujalska-Zadrożny et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test

Vujović¹,

Vučković²,

Vasović³

et al. 2017

Acta Neurobiologiae Experimentalis

View full text Add to dashboard Cite

Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone.Antinociceptive activity was assessed by the formalin test in male Wistar rats (200-250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related behavior after the injection of formalin or vehicle (0.9% NaCl).Ketamine and magnesium sulfate given separately reduced nocifensive behavior in the second phase of the formalin test in rats.When ketamine was applied after magnesium sulfate, the log dose-response curves for the effects of ketamine and the magnesium sulfate-ketamine combination revealed antagonistic interaction, and about 1.6 (CL 1.2-2.4) fold increment in ketamine dosage. A low dose of magnesium sulfate (5 mg/kg, subcutaneously) administered after ketamine increased the antinociceptive effect of ketamine by a factor of only 1.2 (CL 0.95-1.38), indicating an additive interaction. There was a 1.8-fold reduction in dosage of ketamine when ketamine was administered before rather than after the magnesium sulfate.The present study revealed that both ketamine and magnesium reduced pain-related behavior in the second phase of the formalin test in rats. Ketamine, when administered before or after the magnesium, provided additive or antagonistic antinociceptive interactions, respectively. Whether there will be an additive or antagonistic antinociceptive interaction between ketamine and magnesium depends on the order of drug administration.

show abstract

“…Magnesium plays a critical role in a number of physiological processes, including the modulation of nociception by means of the antagonistic action on the N-methyl-d-aspartate (NMDA) receptors (1,2). Indeed, this scientific acquisition resulted from researches carried on in the last decade of the 20 th century (3).…”

Section: Introductionmentioning

confidence: 99%

Inovativna uporaba magnezijeva oksida u liječenju “neuralgije celijačnog pleksusa reumatoidnog podrijetla” G. Moscatija 1923.

Colaci

Ponti

2018

AMHA

View full text Add to dashboard Cite

show abstract

Magnesium enhances opioid-induced analgesia – What we have learnt in the past decades?

Cited by 41 publications

References 185 publications

Complete relief of CRPS-associated pain during magnesium infusion in a patient with postpartum preeclampsia

Complete relief of CRPS-associated pain during magnesium infusion in a patient with postpartum preeclampsia

Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test

Inovativna uporaba magnezijeva oksida u liječenju “neuralgije celijačnog pleksusa reumatoidnog podrijetla” G. Moscatija 1923.

Contact Info

Product

Resources

About