Magnesium efficacy in magnesium deficient and nondeficient patients with rapid ventricular response atrial fibrillation

A Randomized Controlled Trial of Magnesium Sulfate, in Addition to Usual Care, for Rate Control in Atrial Fibrillation

“…All but 1 concluded that the rate reductions were clinically significant. 27 The rate of conversion to sinus rhythm in patients treated with magnesium sulfate varied considerably in these studies. Unfortunately, the sample sizes of these studies were small (ranging from 15 to 57 patients), and differences in study design make it difficult to combine their results for analysis.…”

“…[22][23][24][25][26][27][28] Each of the studies concluded that magnesium sulfate reduced ventricular response rates with minimal adverse sequelae. All but 1 concluded that the rate reductions were clinically significant.…”

“…27 Problematic in this determination is the fact that serum magnesium concentrations may not accurately reflect total body or intracellular magnesium. Patients receiving regular diuretics or patients who are chronic alcoholics may be total body magnesium deplete but may have normal serum magnesium levels.…”

New Onset Atrial Fibrillation in Critically Ill Patients

“…(White et al 1989) However, magnesium seems to be effective in patients with both a low and normal level of serum magnesium. (Eray et al 2000) The optimal dosage of magnesium has not yet been establish. There are different regimens used in clinical trials, which may explain the difference in success of the treatment.…”

Magnesium for the Treatment and Prevention of Atrial Tachyarrhythmias

“…49 Interpretation of the role of magnesium for the prevention of postoperative atrial tachyarrhythmias is complicated by conflicting reports in the literature. [50][51][52][53][54][55][56][57][58][59][60][61] Some studies report no benefit of intra-or postoperative magnesium strategies in patients undergoing CABG surgery, whereas others report clinically and statistically significant reductions in postoperative atrial tachyarrhythmias. These conflicting results may be explained by many factors, including differing dose, duration, or frequency of magnesium administration; administration of magnesium in the pre-, intra-, or postoperative period; or the presence of concomitant ␤-blocker therapy.…”