Magnesium Deficiency in Parathyroid Function

Rude, Robert K.

doi:10.1016/b978-012098651-4/50050-x

Cited by 6 publications

(4 citation statements)

References 95 publications

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“…Under normal circumstances, magnesium modulates PTH secretion in a manner similar to calcium. Both in vitro and in vivo studies have shown that acute elevations in serum magnesium inhibit, while acute reductions stimulate PTH secretion, (31‐34) although magnesium is ∼30–50% less potent than calcium in this regard (34) . In contrast, magnesium‐deficient patients are often characterized by a state of relative hypoparathyroidism.…”

Section: Discussionmentioning

confidence: 99%

Magnesium Deficiency and Bone Loss After Cardiac Transplantation

Boncimino

McMahon

Addesso

et al. 1999

Journal of Bone and Mineral Research

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Magnesium depletion adversely affects many phases of skeletal metabolism and has been implicated as a risk factor in several forms of osteoporosis. Magnesium deficiency has also been reported after cardiac transplantation. To evaluate whether altered magnesium homeostasis could be related to the pathogenesis of early bone loss after cardiac transplantation, we prospectively measured serum and urinary magnesium and evaluated them with respect to biochemical indices of mineral metabolism and rates of bone loss. The study population included 60 patients (45 men, 15 women) aged 53 ± 11 years (SD) with measurements of biochemistries and bone mineral density by dual-energy X-ray absorptiometry before and 3 months after transplantation. All received prednisone, cyclosporine A, and azathioprine, plus calcium (1000 mg) and vitamin D (400 IU). After transplantation, serum magnesium decreased by 16 ± 15% (SD) from 2.0 ± 0.3 mg/dl to 1.6 ± 0.2 mg/dl (normal 1.8-2.2 mg/dl; p < 0.0001), accompanied by an increase in the fractional excretion of magnesium (7.1 ± 3.9% to 13.3 ± 5.6%; p < 0.0017). Forty-three patients with low 3-month serum magnesium levels (р 1.7 mg/dl) sustained 41% less bone loss at the lumbar spine (4.0 ± 4.6% vs. 6.8 ± 5.3%; p = 0.051) and 58% less bone loss at the femoral neck (3.1 ± 5.9% vs. 7.3 ± 5.6%; p < 0.01), despite receiving similar doses of prednisone and cyclosporine A. Of the biochemical parameters measured (including renal function, serum calcium, phosphorus, vitamin D metabolites, osteocalcin, urinary calcium, and markers of bone resorption), only intact parathyroid hormone (PTH) levels, which were 40% lower in patients with low serum magnesium levels differed significantly (45 ± 23 pg/ml vs. 74 ± 60 pg/ml; p = 0.019). Patients with low serum magnesium levels also had evidence of lower bone turnover. In summary, a highly significant decline in serum magnesium concentrations, associated with continued urinary magnesium losses, occurs after cardiac transplantation. Patients with low serum magnesium levels had significantly lower rates of bone loss, lower serum PTH concentrations, and lower bone turnover. Although the precise mechanisms by which the reduction in serum magnesium tends to protect against bone loss in the early post-transplantation period remain to be elucidated, reduced serum PTH and lower rates of bone turnover are likely to be important factors. (J Bone Miner Res 1999;14:295-303)

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Section: Discussionmentioning

confidence: 99%

Magnesium Deficiency and Bone Loss After Cardiac Transplantation

Boncimino

McMahon

Addesso

et al. 1999

Journal of Bone and Mineral Research

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“…Second, coexistent sarcoidosis and/or vitamin D toxicity might suppress intact PTH levels even in patients with primary hyperparathyroidism and hypercalcaemia, 12 but neither clinical problem was present in our patients. Third, another uncommon cause for low or undetectable serum intact PTH levels is hypomagnesaemia because magnesium is necessary for both synthesis and secretion of intact PTH and its action 13 . Our first patient had recurrent episodes of pancreatitis, which can cause severe hypomagnesaemia that in turn could result in defective synthesis and secretion of intact PTH 13 .…”

Section: Discussionmentioning

confidence: 90%

“…Third, another uncommon cause for low or undetectable serum intact PTH levels is hypomagnesaemia because magnesium is necessary for both synthesis and secretion of intact PTH and its action. 13 Our first patient had recurrent episodes of pancreatitis, which can cause severe hypomagnesaemia that in turn could result in defective synthesis and secretion of intact PTH. 13 However, serum magnesium was normal in both patients and persistent hypercalcaemia should not occur in the setting of suppressed or low intact PTH levels.…”

Section: Discussionmentioning

confidence: 99%

Very low or undetectable intact parathyroid hormone levels in patients with surgically verified parathyroid adenomas

Bhadada¹,

Cardenas

Bhansali³

et al. 2008

Clinical Endocrinology

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When the clinical suspicion is high, the diagnosis of primary hyperparathyroidism should be pursued despite suppressed or low-normal serum intact PTH levels after carefully excluding other causes of hypercalcaemia. Further research on various intact PTH molecular species secreted by parathyroid adenomas or post-translational changes in the intact PTH molecule that might interfere with in vitro measurements should be undertaken to understand the precise reason(s) for such anomalous findings.

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“…Magnesium: This essential mineral, abundant in coffee, plays a crucial role in muscle function, energy production, and bone health [35]. Studies suggest moderate coffee consumption may be associated with increased magnesium intake and potentially lower risk of magnesium deficiency [36].…”

Section: Potential Impacts On Health Markersmentioning

confidence: 99%

A Review of Coffee's Quality Attributes and Potential Health Benefits

Girma

2024

IJFSB

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This review delves into the multifaceted world of coffee, examining its historical journey, cultural significance, and potential health effects. It explores the sensory experience, highlighting how bean origin, processing methods, and brewing techniques influence the perception of taste and aroma. The review then delves into the potential health benefits associated with coffee's bioactive compounds, particularly caffeine and antioxidants. Studies suggest moderate coffee consumption may be associated with a reduced risk of chronic diseases like type 2 diabetes and certain cancers, likely due to the presence of antioxidants. However, the review emphasizes individual factors like caffeine sensitivity and health status play a crucial role in determining optimal intake. It advocates for mindful brewing practices and moderation to maximize the enjoyment and potential health benefits of this globally beloved beverage. Nevertheless, the review acknowledges the need for further research to fully understand the long-term consequences of coffee consumption and its interactions with specific health conditions. In essence, this review offers a comprehensive and scientifically informed overview of coffee, encompassing its historical roots, sensory profiles, potential health advantages, and considerations for responsible consumption.

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Magnesium Deficiency in Parathyroid Function

Cited by 6 publications

References 95 publications

Magnesium Deficiency and Bone Loss After Cardiac Transplantation

Magnesium Deficiency and Bone Loss After Cardiac Transplantation

Very low or undetectable intact parathyroid hormone levels in patients with surgically verified parathyroid adenomas

A Review of Coffee's Quality Attributes and Potential Health Benefits

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Magnesium Deficiency in Parathyroid Function

Cited by 6 publications

References 95 publications

Magnesium Deficiency and Bone Loss After Cardiac Transplantation

Magnesium Deficiency and Bone Loss After Cardiac Transplantation

Very low or undetectable intact parathyroid hormone levels in patients with surgically verified parathyroid adenomas

A Review of Coffee&apos;s Quality Attributes and Potential Health Benefits

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Product

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A Review of Coffee's Quality Attributes and Potential Health Benefits