Magnesium Deficiency in Fibromyalgia Syndrome

Abstract

Since patients with either jibromyalgia syndrome (FS) or low magnesium (Mg) levels can have fatigue, sleep disturbance and anxiety, it was necessary to determine i f some patients with FS also have low Mg levels. Both red blood cell (RBC) and plasma Mg levels were measured in 100 consecutive FS patients and 12 osteoarthritis (OA) control patients. Compared to reference laboratory and OA controls, FS patients had significantly lower RBC Mg levels. The plasma Mg levels of FS patients were no different than the reference laboratory or OA controls. Some FS patients have low Mg levels, a problem that is potentially correctable.

Relation between magnesium and calcium and parameters of pain, quality of life and depression in women with fibromyalgia

“…Magaldi et al [28] presented in their study that patients with FM had normal levels of serum Mg and reduced levels in leucocytes. This confirms the assumption that serum Mg is a poor predictor of the Mg status in the body as a whole, and that intracellular analyses are more representative [11,16,[29][30][31][32].…”

Inovativna uporaba magnezijeva oksida u liječenju “neuralgije celijačnog pleksusa reumatoidnog podrijetla” G. Moscatija 1923.

“…Secondly, deregulation in the sympathetic autonomic and hypothalamic-pituitary-adrenal systems was also described in FM (40). The rationale of use is the relative decrease of Mg levels in FM patients, namely in muscle cells or erythrocytes (41)(42)(43); moreover, a daily oral Mg supplementation improves FM symptoms (41,44). In light of recent knowledge on the central nervous origin of pain associated with fibromyalgia, Mg supplementation may be considered useful to inhibit the development of neuropathic pain, thanks to its antagonist action on NMDA receptors, which are important in the process of central sensitization (2).…”

El hambre oculta y la fibromialgia: Una revisión sistemática

“…The association between FM development and mineral deficiency has been investigated. For example, Romano and Stiller 44 indicated that Mg participates in ATP synthesis and it is important for muscle metabolism, thus its reduction would contribute to the progression of FM. The serum levels of selenium (Se) in FM patients were lower compared to their controls of the same age and sex 45 .…”