Magnesium Deficiency and Urea Cycle Enzymes in Rat Liver.

Lizarralde, German; Mazzocco, V. E.; Flink, Edmund B.

doi:10.3181/00379727-126-32414

Cited by 4 publications

(2 citation statements)

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“…These data suggest disturbed protein synthesis [28]. In a subsequent experiment [29] aspartate transcarbamylase and ribonuclease activities as well as RNA and DNA content of the liver of Mg-depleted rats were found to be increased.…”

Section: Abnormal Amino Acid Metabolismmentioning

confidence: 79%

Magnesium deficiency in human subjects—a personal historical perspective.

Flink¹

1985

Journal of the American College of Nutrition

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Over the past 30 years human magnesium (Mg) deficiency has become an accepted fact in most medical circles. Our index patient had striking neurological manifestations including generalized tremulousness, grimaces and fibrillary twitches of facial muscles, athetoid and choreiform movements of upper extremities, dysphagia, inability to speak, repeated convulsions, and confusion. She had received glucose in water and saline intravenously for several months. A patient with chronic alcoholism was noted to have almost identical symptoms and signs as the index patient. He also responded dramatically to MgSO4 injections. This resulted in a series of studies on patients with chronic alcoholism. The evidence of Mg deficiency in alcoholism includes the following: significant hypomagnesemia, strongly positive Mg balance during recovery, significant decrease in muscle Mg, a deficit of total exchangeable 28Mg quantitatively similar to deficit by balance studies, often a dramatic response of symptoms to therapy with Mg, and diuresis of Mg produced by ingestion of alcohol. Lipolysis with high levels of long-chain free fatty acids (FFA) occurs in withdrawal of alcohol in chronic alcoholism, withdrawal of certain addictive drugs, after trauma, surgery, administration of adrenergic compounds or theophylline, exposure to cold, and an adverse environment as in grass staggers. Concentrations of Mg fall when FFA increase in all of the above circumstances. This phenomenon has wide implications in health and disease. Better awareness of Mg deficiency in a wide variety of clinical conditions will result in life-saving treatment and less morbidity of other patients.

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Section: Abnormal Amino Acid Metabolismmentioning

confidence: 79%

Magnesium deficiency in human subjects—a personal historical perspective.

Flink¹

1985

Journal of the American College of Nutrition

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“…Decreased activities of succinate dehydrogenase, adenosine triphosphatase and ornithine transcarbamoylase have also been observed in tissues from magnesiumdeficient rats (Lindner eta/., 1962;Lizarralde et a/., 1967), but the mechanism of the inhibition is not established.…”

Section: Eflect On Enzymic Octivity It1 Vicomentioning

confidence: 99%

Magnesium Requirement for Enzymes and Hormones

Heaton

1973

Biochemical Society Transactions

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Magnesium has been shown to activate many enzymes i~z vitro. Among them are most of the enzymes acting on phosphorylated substrates, including kinases, synthetases and phosphatases, and many of the enzymes that catalyse carbonyl addition reactions, including all those requiring thiamin pyrophosphate as a cofactor (Mahler, 1961). Some of these enzymes are also activated by other bivalent metals, particularly by Mn, but consideration of the intracellular abundance of metals indicates that Mg is likely to be the physiological activator. Activation of eiizyrnes in citro Enzyme activation may be brought about by Mg complexing with either the substrate or the enzyme protein. Kinetic studies with several enzymes that require both Mg and ATP, including creatine kinase (Kuby et al., 1954), mitochondria1 adenosine triphosphatase (Ulrich, 1964) and hexokinase (Bachelard, 1971). have shown maximum activity in the presence of a 1 : 1 ratio of the two cofactors, with an excess of either usually being inhibitory. Mg chelates strongly with ATP to form a quadridentate ligand (Szent-Gyiirgyi, 1957), theelrect of this being to lower the freeenergy ofactivation Vol. 1

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Magnesium Metabolism in Chronic Renal Disease*

Randall

1969

Annals of the New York Academy of Sciences

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Magnesium Deficiency and Urea Cycle Enzymes in Rat Liver.

Cited by 4 publications

References 1 publication

Magnesium deficiency in human subjects—a personal historical perspective.

Magnesium deficiency in human subjects—a personal historical perspective.

Magnesium Requirement for Enzymes and Hormones

Magnesium Metabolism in Chronic Renal Disease*

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