Magnesium Deficiency and Cardiometabolic Disease

Abstract

Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. In this review, we examine how Mg2+ homeostasis is maintained within the body and highlight the various molecular roles attributed to Mg2+ in the cardiovascular system. In addition, we describe how nutritional and/or disease-associated magnesium deficiency, seen in some metabolic conditions, has the potential to influence cardiac and vascular outcomes. Finally, we also examine the potential for magnesium supplements to be employed in the prevention and treatment of cardiovascular disorders and in the management of cardiometabolic health.

Recent advancements in Mg-based micromotors for biomedical and environmental applications

“…50 Studies reported that insulin can enhance cellular Mg uptake among patients with diabetes, and Mg intake is correlated to the degree of hyperglycaemia. 51 A person deficient in Mg will present with health issues such as cardiometabolic disease, 52 moderate tension-type headaches, 53 and alcohol-related liver injury. 54 Currently, Mg is widely used in bone scaffolds in the body.…”