Magnesium-containing bioactive polycrystalline silicate-based ceramics and glass-ceramics for biomedical applications

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

“…into amorphous silica walls exhibited stimulation effects on osteoblast differentiation and therefore the formation of new bone in vivo. 13,14 Furthermore, the incorporation of Mg-containing particles into scaffolds could tailor a number of important properties, such as crystallinity and degradation, to satisfy the requirements for bone tissue engineering. 15 It is therefore expected that incorporation of m-MS into PBSu scaffolds could modify its properties and overcome the above limitations of using PBSu scaffolds alone for bone regeneration.…”

In vitro degradability, bioactivity and primary cell responses to bone cements containing mesoporous magnesium–calcium silicate and calcium sulfate for bone regeneration

“…The magnesium (Mg) ion is a small but important component of bone tissue: deficiency of Mg ions seems to be a risk factor for osteoporosis in humans [7], and Mg ions were reported to be associated with the mineralization of calcified tissues and could influence mineral metabolism through the activation of alkaline phosphatase (ALP) [8,9]. The degradation products of magnesium-containing materials were not only non-toxic but were also involved in various biological processes such as cellular processes, metabolism of vitamin D and enhanced osteogenic gene expression [10].…”

Biocompatibility, degradability, bioactivity and osteogenesis of mesoporous/macroporous scaffolds of mesoporous diopside/poly( l -lactide) composite

“…The silicate ceramics in CaO-SiO 2 -MgO systems have been reported to produce some ions (such as Ca, Mg and Si) that could stimulate osteoblast proliferation and differentiation [3,4]. Another study has reported that the DP ceramics could be used not only for bone tissue engineering but also for periodontal tissue engineering owing to their excellent in vitro and in vivo osteogeneis/cementogenesis [5,6].…”

“…for 84 days, and the Tris-HCl solution was refreshed once a week. At specific time intervals (1,3,5,7,14,21,28,35,49,63 and 84 days), the specimens were washed thoroughly with deionized water, then dried at 808C in an oven for 12 h. …”