Magnesium-Based Temporary Implants: Potential, Current Status, Applications, and Challenges

Seetharaman, Sankaranarayanan; Sankaranarayanan, Dhivya; Gupta, Manoj

doi:10.3390/jfb14060324

Cited by 19 publications

(19 citation statements)

References 160 publications

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“…[45,55,56] The investigations demonstrated that MAO-produced and Sr-P coatings have high degradation resistance, while CaP coatings can improve wear resistance. [57] Microstructural evolutions can also lead to significant changes in Mg-based biomaterials, for or hydroxyapatite (HA) [163,168] Tissue engineering scaffolds Mg-based coatings with controlled degradation rate and osteogenic ability Fluorohydroxyapatite (FHA) coating on magnesium alloys [163,171] Drug delivery systems Mg-based coatings with pH-responsive and sustained-release properties Degradable polymer coatings, silk fibroin coatings, and hierarchical hybrid coatings [163,167,172] www.advancedsciencenews.com www.aem-journal.com example, grain refinement by utilization of equal channel angular pressing or other variants of severe plastic deformation methods may enhance both the mechanical properties and degradation rate; this can lead to the fabrication of denser and thicker coating layers with improved corrosion resistance. [12,[58][59][60][61][62] In addition to the usual previous methods, new techniques and procedures have been proposed, invented, and studied for the better development of multifunctional coatings, such as plasma-induced thermal-field-assisted crosslinking deposition (PTCD) that is an environment-friendly method, enabling the fabrication of hierarchical textures with potential for the simultaneous growth of the inorganic layer and organic layer.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Li,

Kong,

Zhang

2024

Adv Eng Mater

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Multifunctional materials are propitious materials with numerous functionalities that make them an ideal option for implants and biomedical applications that should simultaneously fulfill various requirements, including satisfactory mechanical strength, biocompatibility, antibacterial property, hydrophilicity, drug delivery, etc. Magnesium, as a metallic biomaterial, fulfills the required mechanical properties, but unfortunately, in some ways alone, it cannot provide the required biological properties. For instance, Mg alloys suffer from poor corrosion resistance and high biodegradability, which should be carefully controlled. On the other hand, multifunctional materials alone are not able to provide the required properties in biomedical applications because the vast majority of them do not have the necessary strength and stability. Therefore, the use of magnesium together with multifunctional or composite coatings will be a very advantageous choice for meeting the needs of implants and biomedical materials. The current study focuses on the introduction and utilization of various multifunctional coatings and composites on Mg‐based alloys for biomedical applications. Numerous organic and inorganic materials could be utilized as composites or multifunctional materials, such as polymers, hydroxyapatites, hydrogels, calcium phosphates, alginates, hyaluronic acids, chitosan, etc. In this regard, numerous types of coating and composite materials, their production technologies, mechanisms, resultant properties, and the involved parameters are thoroughly discussed to provide a comprehensive guide for those interested in this field. It is hoped that this study will pave the way for the production of advanced and smart multifunctional materials with unique properties and play a role in the design of a new generation of Mg‐based biomedical materials.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%

Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Li,

Kong,

Zhang

2024

Adv Eng Mater

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“…The performance of Mg can be ameliorated through various means, one of which is alloying [ 10 , 11 ]. Alloying elements should be nontoxic or have extremely low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Extrusion on Mechanical Property, Corrosion Behavior, and In Vitro Biocompatibility of the As-Cast Mg-Zn-Y-Sr Alloy

Huang,

Yang,

et al. 2024

Materials

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The effect of extrusion on the microstructure, mechanical property, corrosion behavior, and in vitro biocompatibility of as-cast Mg-1.5Zn-1.2Y-0.1Sr (wt.%) alloy was investigated via tensile tests, electrochemical methods, immersion tests, methylthiazolyl diphenyltetrazolium bromide (MTT), and analytical techniques. Results showed that the as-cast and as-extruded Mg-1.5Zn-1.2Y-0.1Sr alloys comprised an α-Mg matrix and Mg3Y2Zn3 phase (W-phase). In the as-cast alloy, the W-phase was mainly distributed at the grain boundaries, with a small amount of W-phase in the grains. After hot extrusion, the W-phase was broken down into small particles that were dispersed in the alloy, and the grains were refined considerably. The as-extruded alloy exhibited appropriate mechanical properties that were attributed to refinement strengthening, dispersion strengthening, dislocation strengthening, and precipitation strengthening. The as-cast and as-extruded alloys exhibited galvanic corrosion between the W-phase and α-Mg matrix as the main corrosion mechanism. The coarse W-phase directly caused the poor corrosion resistance of the as-cast alloy. The as-extruded alloy obtained via hydrogen evolution and mass loss had corrosion rates of less than 0.5 mm/year. MTT, high-content screening (HCS) analysis, and cell adhesion tests revealed that the as-extruded alloy can improve L929 cell viability and has great potential in the field of biomedical biodegradable implant materials.

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“…The Mg13Sn alloy has garnered substantial attention in the biomedical field, particularly in the context of implants [ 23 ]. The alloy’s unique mechanical properties, combined with its high biocompatibility and excellent biodegradability, make it an ideal candidate for orthopedic and other types of implants [ 24 ]. A significant area of research regarding this alloy is its machining properties, including milling [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Machining Parameters to Minimize Cutting Forces and Surface Roughness in Micro-Milling of Mg13Sn Alloy

Ercetin,

Aslantaş,

Özgün

et al. 2023

Micromachines

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This comprehensive study investigates the micro-milling of a Mg13Sn alloy, a material of considerable interest in various high-precision applications, such as biomedical implants. The main objective of the study was to explore the optimizations of variable feed per tooth (fz), cutting speed (Vc), and depth of cut (ap) parameters on the key outcomes of the micro-milling process. A unique experimental setup was employed, employing a spindle capable of achieving up to 60,000 revolutions per minute. Additionally, the study leveraged linear slides backed by micro-step motors to facilitate precise axis movements, thereby maintaining a resolution accuracy of 0.1 μm. Cutting forces were accurately captured by a mini dynamometer and subsequently evaluated based on the peak to valley values for Fx (tangential force) and Fy (feed force). The study results revealed a clear and complex interplay between the varied cutting parameters and their subsequent impacts on the cutting forces and surface roughness. An increase in feed rate and depth of cut significantly increased the cutting forces. However, the cutting forces were found to decrease noticeably with the elevation of cutting speed. Intriguingly, the tangential force (Fx) was consistently higher than the feed force (Fy). Simultaneously, the study determined that the surface roughness, denoted by Sa values, increased in direct proportion to the feed rate. It was also found that the Sa surface roughness values decreased with the increase in cutting speed. This study recommends a parameter combination of fz = 5 µm/tooth feed rate, Vc = 62.8 m/min cutting speed, and ap = 400 µm depth of cut to maintain a Sa surface roughness value of less than 1 µm while ensuring an optimal material removal rate and machining time. The results derived from this study offer vital insights into the micro-milling of Mg13Sn alloys and contribute to the current body of knowledge on the topic.

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Magnesium-Based Temporary Implants: Potential, Current Status, Applications, and Challenges

Cited by 19 publications

References 160 publications

Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Effect of Extrusion on Mechanical Property, Corrosion Behavior, and In Vitro Biocompatibility of the As-Cast Mg-Zn-Y-Sr Alloy

Optimization of Machining Parameters to Minimize Cutting Forces and Surface Roughness in Micro-Milling of Mg13Sn Alloy

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