Magnesium Balance and Protein Intake Level in Adult Human Female

Hunt, Sara; Schofield, Frances A.

doi:10.1093/ajcn/22.3.367

Cited by 30 publications

(14 citation statements)

References 11 publications

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“…We used Cox proportional hazards modeling to study the association between quartiles of dietary magnesium intake/Kg with HF hospitalization adjusting for variables used in the ARIC HF prediction model (age, sex, coronary heart disease, body mass index, diabetes, systolic blood pressure, blood pressure medication use, heart rate, smoking status) 26 and dietary measures influencing intestinal magnesium absorption and excretion such as intake of phosphorus 27 , protein 28, 29 , and alcohol 30 using the lowest dietary magnesium/Kg quartile as the reference category (0.522 to 2.308mg/Kg). Adjustment for alcohol intake was made as chronic alcohol consumption increases urinary magnesium excretion and reduces total muscle magnesium content.…”

Section: Methodsmentioning

confidence: 99%

Relation of Magnesium Intake With Cardiac Function and Heart Failure Hospitalizations in Black Adults

Taveira

Ouellette

Gulum

et al. 2016

Circ: Heart Failure

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Background Little is known about the relations of magnesium intake with risk of heart failure (HF) hospitalizations, particularly in African-Americans. We hypothesize that magnesium intake relates to HF hospitalization in African-Americans. Methods and Results From the Jackson Heart Study cohort (n=5,301), we studied 4,916 African-Americans recruited during 2000–2004 in Jackson (MS), who completed an 158-item Food-Frequency Questionnaire which included dietary supplements. Total daily magnesium intake derived from the questionnaire was divided by the body weight (Kg) to account for body storage, and stratified by quartiles (0.522–2.308, 2.309–3.147, 3.148–4.226 and ≥4.227mg magnesium intake/Kg). Cox proportional hazards modeling assessed the association between quartiles of magnesium intake/Kg and hospitalizations for HF adjusting for HF risk, energy intake and dietary factors affecting magnesium uptake. The cohort had a mean age=55.3 (SD=12.7yrs), and composed of 63.4% women, 21.6% diabetes, 62.7% hypertension, 7.1% coronary disease and 2.8% with known HF. When compared to participants in the first quartile of magnesium intake/Kg, those with higher magnesium intake (>2.308 mg/kg) had decreased risk of HF admission, with adjusted hazard ratios of 0.66(95%CI: 0.47–0.94) in the second quartile to 0.47 (95% CI: 0.27–0.82) in the highest quartile. Results were similar when individuals with previous diagnosed HF (2.8%) were excluded or when the analysis was repeated using quartiles of magnesium intake without accounting for body weight. Conclusions Magnesium intake below 2.3mg/Kg (~181 mg/day) was related to increased risk for subsequent HF hospitalizations. Future studies are needed to test whether serum Magnesium levels and/or intake predict risk of heart failure.

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Section: Methodsmentioning

confidence: 99%

Relation of Magnesium Intake With Cardiac Function and Heart Failure Hospitalizations in Black Adults

Taveira

Ouellette

Gulum

et al. 2016

Circ: Heart Failure

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“…[147][148][149][150][151] The best available method for estimating magnesium requirements is the dietary balance approach. 125 The balance study is based on individuals who consume a diet with known magnesium content.…”

Section: Magnesium Balance Studiesmentioning

confidence: 99%

New Perspectives in Magnesium Research

Nishizawà¹,

Morii²,

Durlach³

2007

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“…It was also stated that previously derived magnesium requirements by other authorities may have been overestimates. Based on magnesium intake on a body weight basis considered by similar committees in the USA, the EU and the UK to maintain zero magnesium balance and considering, in particular, balance studies enabling the development of an equilibrium (Hunt and Schofield, 1969;Marxhall et al, 1976;Mahalko et al, 1983;Andon et al, 1996), Recommended Nutrient Intakes were proposed which were denoted as provisional. The results of a study on nutritional rehabilitation of children suffering from protein-energy malnutrition who were receiving or not receiving magnesium supplements (Nichols et al, 1978) were considered to support the value derived for young children.…”

Section: Infants and Childrenmentioning

confidence: 99%

Scientific Opinion on Dietary Reference Values for magnesium

Products¹

2015

EFS2

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Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for magnesium. The Panel considers that Average Requirements (ARs) and Population Reference Intakes (PRIs) for magnesium cannot be derived for adults, infants or children, and therefore defines Adequate Intakes (AIs), based on observed intakes in healthy populations in the European Union (EU). This approach considers the range of average magnesium intakes estimated by EFSA from dietary surveys in children and adults in nine EU countries. For adults, an AI for magnesium is set at 350 mg/day for men and 300 mg/day for women. For children aged 1 to < 3 years, an AI for magnesium is set at 170 mg/day for both sexes. For children aged 3 to < 10 years, an AI for magnesium is set at 230 mg/day for both sexes. For children aged 10 to < 18 years, an AI for magnesium is set at 300 mg/day for boys and 250 mg/day for girls. For infants aged 7-11 months, an AI for magnesium of 80 mg/day is derived by extrapolating upwards from the estimated magnesium intake in exclusively breast-fed infants aged 0-6 months and by considering observed average intakes in the few surveys for which data are available. For pregnant and lactating women, the Panel considers that there is no evidence for an increased need for magnesium, and the same AI is set for them as for non-pregnant, non-lactating women. Magnesium is an alkaline earth metal. It occurs as the free cation Mg 2+ in aqueous solutions or as the mineral part of a large variety of compounds, including chlorides, carbonates and hydroxides. Magnesium is a cofactor of more than 300 enzymatic reactions, acting either on the enzyme itself as a structural or catalytic component or on the substrate, especially for reactions involving ATP, which make magnesium essential in the intermediary metabolism for the synthesis of carbohydrates, lipids, nucleic acids and proteins, as well as for specific actions in various organs in the neuromuscular or cardiovascular system. Magnesium deficiency can cause hypocalcaemia and hypokalaemia, leading to neurological or cardiac symptoms when it is associated with marked hypomagnesaemia. Owing to the widespread involvement of magnesium in numerous physiological functions and the metabolic interactions between magnesium and other minerals, it is difficult to relate magnesium deficiency to specific symptoms.Magnesium absorption takes place in the distal intestine, mainly as the ionised form. Percentage absorption is generally considered to be 40-50 %, but figures from 10 to 70 % have also been reported. Magnesium absorption can be inhibited by phytic acid and phosphate and enhanced by the fermentation of soluble dietary fibre, although the physiological relevance of these interactions at adequate intakes remains to be established.The majority of the body magnesium content is stored in bone (about 60 %) and muscle (about 25 %). A small amount is present in the serum, mainly as the free cation. Most cells ...

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Magnesium Balance and Protein Intake Level in Adult Human Female

Cited by 30 publications

References 11 publications

Relation of Magnesium Intake With Cardiac Function and Heart Failure Hospitalizations in Black Adults

Relation of Magnesium Intake With Cardiac Function and Heart Failure Hospitalizations in Black Adults

New Perspectives in Magnesium Research

Scientific Opinion on Dietary Reference Values for magnesium

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