Magnesium appetite in the rat

McCaughey, Stuart A.; Tordoff, Michael G.

doi:10.1006/appe.2001.0443

Cited by 25 publications

(21 citation statements)

References 39 publications

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“…We found that K + deprivation increased short-term licking for several chloride salts (NaCl, KCl, CaCl 2 , FeCl 2 , MgCl 2 and CsCl), many of which did not contain K + . Furthermore, K + deprivation did not enhance licking for KHCO 3 . These results show that K + deprivation does not produce an unlearned appetite specifically for K + salts.…”

Section: Appetite Specificitymentioning

confidence: 78%

“…For example, calcium-deprived rats showed appetites for some chloride-containing stimuli, such as CaCl 2 , NaCl, NH 4 Cl, FeCl 2 , MgCl 2 , KCl, and ZnCl 2 , but not for CsCl, and only within a narrow concentration range for some of the chloride salts listed above, while they also showed elevated intake of calcium gluconate [2]. Magnesium-deprived rats showed appetites for MgCl 2 and CaCl 2 , but not NaCl [3]. Sodium-deprived rats displayed elevated consumption of a variety of sodium-containing compounds [20,43] and LiCl [20], but reports vary as to whether they also show an appetite for KCl [20,30,31,53].…”

Section: Other Observations and Perspectivesmentioning

confidence: 99%

“…Surprisingly, there is not clear evidence that K + -deprived rats develop a compensatory appetite that helps to relieve their deficit, as they do when deprived of sodium [1], calcium [2], magnesium [3], phosphorus [4,5], iron [6], zinc [7], copper [8], or selenium [9]. Blake and Jurf [10] reported that K + -deprived rats increased consumption of NaCl solutions but decreased or did not adjust intake of KCl solutions in 24-h two-bottle preference tests (versus water).…”

Section: Introductionmentioning

confidence: 99%

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Licking for taste solutions by potassium-deprived rats: Specificity and mechanisms

Guenthner

McCaughey

Tordoff

et al. 2008

Physiology & Behavior

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There has been little work on the specificity and mechanisms underlying the appetite of potassium (K + ) deprived rats, and there are conflicting results. To investigate the contribution of oral factors to changes in intake induced by K + deficiency, we conducted two experiments using 20-s "brief access" tests. In Experiment 1, K + -deprived rats licked less for water than did replete rats. After adjusting for this difference, K + -deprived rats exhibited increased licking for 100 mM CaCl 2 , 100 mM MgCl 2 , and 100 mM FeCl 2 compared with K + -replete rats. In Experiment 2, which used larger rats, the K + -deprived and replete groups licked equally for water, 500 mM Na·Gluconate, 350 mM KCl, 500 mM KHCO 3 , and 1 mM quinine·HCl, but the K + -deprived rats licked more for 500 mM KCl, 500 mM CsCl, and 500 mM NaCl than did the replete rats. Licking was unaffected by addition to NaCl of 200 μM amiloride, an epithelial Na + channel (ENaC) blocker, or 100 μM ruthenium red, a vanilloid receptor 1 (VR-1) antagonist, or by addition to KCl of 50 μM 4-aminopyridine, a K + channel blocker. These findings suggest that K + -deprivation produces a non-specific appetite that is guided by oral factors. We found no evidence that this response was mediated by ENaC, VR-1, or K + channels in taste receptor cells.

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Section: Appetite Specificitymentioning

confidence: 78%

Section: Other Observations and Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Licking for taste solutions by potassium-deprived rats: Specificity and mechanisms

Guenthner

McCaughey

Tordoff

et al. 2008

Physiology & Behavior

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“…However, in the wild, many frugivores have a mixed diet (Guzmán and Stevenson 2008;Moskovits and Bjorndal 1990) and it is difficult to find a correlation between fruit eaten and fruit preferences reported in experiments (Carlo and Morales 2008). This could be because frugivores respond to their nutritional needs (Murphy and King 1987), tending to balance their nutrient intake (McCaughey and Tordoff 2002). Thus, their choice of food could be driven by immediate needs for particular nutrients rather than exclusively by their innate or learned preferences.…”

Section: Impact Of Memory On Service To Each Of Two Competing Plants mentioning

confidence: 99%

Plant ecology meets animal cognition: impacts of animal memory on seed dispersal

et al. 2016

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We propose that an understanding of animal learning and memory is critical to predicting the impacts of animals on plant populations through processes such as seed dispersal, pollination and herbivory. Focussing on endozoochory, we review the evidence that animal memory plays a role in seed dispersal, and present a model which allows us to explore the fundamental consequences of memory for this process. We demonstrate that decision-making by animals based on their previous experiences has the potential to determine which plants are visited, which fruits are selected to be eaten from the plant and where seeds are subsequently deposited, as well as being an important determinant of animal survival. Collectively, these results suggest that the impact of animal learning and memory on seed dispersal is likely to be extremely important, although to date our understanding of these processes suffers from a conspicuous lack of empirical support. This is partly because of the difficulty of conducting appropriate experiments but is also the result of limited interaction between plant ecologists and those who work on animal cognition.We believe that an improved understanding of the effects of animal memory in endozoochorous interactions will allow better prediction of the impacts of ecosystem changes such as habitat fragmentation, introductions of novel species of plants and animals and reintroductions of animal populations to areas from which they have been extirpated, and hope that the ideas we put forward here provide an impetus for further work in this area.

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“…Stress, diet and lifestyles are closely linked to imbalances [53] in magnesium therapy that may accelerate aging with disturbances in eating [54], growth and nutrient metabolism that may involve dietary fat/carbohydrate [55]- [58] (Figure 1). Diets that contain xenobiotics [39]/bacterial lipopolysaccharides (LPS) are involved in post-transcriptional modifications with magnesium/Sirt1 dysregulation in diabetes and Alzheimer's disease that may involve toxic amyloidogenic pathways and myocardial infarction in global populations [59]- [63].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease

Martins¹

2016

Health

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In the current global epidemic for Non Alcoholic Fatty Liver Disease (NAFLD), diabetes and neurodegenerative diseases such as Alzheimer's disease there has been a major interest in magnesium therapy to delay the severity of NAFLD, Type 3 diabetes and neurodegeneration in the developing and developed world. The objective of magnesium therapy is to activate the anti-aging gene Sirtuin 1 (Sirt1) to prevent cardiovascular disease, NAFLD and diabetes. Reduced consumption of nutrients such as fatty acids, glucose, cholesterol and increased magnesium consumption is closely linked to reduced bacterial lipopolysaccharides (LPS) and activation of Sirt1 relevant to active nuclear and mitochondria interactions with the prevention of myocardial infarction and Type 3 diabetes. Magnesium deficiency and its effects on Sirt1 regulation have become important with magnesium deficiency associated with appetite dysregulation, senescence, glucose/nitric oxide dyshomeostasis, increased ceramide and toxic amyloid beta formation. Magnesium therapy activates the peripheral sink amyloid beta clearance pathway with the reversal of cell senescence associated with various chronic diseases such as cardiovascular disease, Type 3 diabetes and Alzheimer's disease.

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Magnesium appetite in the rat

Cited by 25 publications

References 39 publications

Licking for taste solutions by potassium-deprived rats: Specificity and mechanisms

Licking for taste solutions by potassium-deprived rats: Specificity and mechanisms

Plant ecology meets animal cognition: impacts of animal memory on seed dispersal

Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease

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