Magnesium and Ketamine Reduce Early Morphine Consumption After Open Bariatric Surgery: a Prospective Randomized Double-Blind Study

Jabbour, Hicham; Jabbour, Khalil; Lutfallah, Antoine Abi; Zeid, Hicham Abou; Nasser-Ayoub, E; Haidar, Marc Abou; Naccache, Nicole

doi:10.1007/s11695-019-04317-1

Cited by 20 publications

(15 citation statements)

References 40 publications

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“…Jarahzadeh et al reported that the intravenous use of magnesium sulfate (50 mg/kg) could provide effective analgesia and reduce requirement and adverse events of morphine after abdominal hysterectomy under general anesthesia. In other studies on obese patients who underwent open or laparoscopic sleeve gastrectomy, postoperative pain and opioid requirement were significantly lower in patients treated with magnesium sulfate [27,28,31]. A study of liver transplantation showed that the intravenous administration of magnesium sulfate could reduce the requirement of tramadol and the need for mechanical ventilation [32].…”

Section: Magnesium and Perioperative Painmentioning

confidence: 95%

“…Magnesium is a critical participant in various physiological processes of the body. Therefore, much attention has focused on anesthesiology [ 23 ], resulting in many clinical trials [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ], reviews, and meta-analyses [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. In particular, the pain attenuation effect of magnesium was investigated to improve the outcomes in surgical patients.…”

Section: Magnesium and Perioperative Painmentioning

confidence: 99%

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Magnesium and Pain

Shin

Hwan

2020

Nutrients

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In terms of antinociceptive action, the main mode of action of magnesium involves its antagonist action at the N-methyl-d-aspartate (NMDA) receptor, which prevents central sensitization and attenuates preexisting pain hypersensitivity. Given the pivotal function of NMDA receptors in pain transduction, magnesium has been investigated in a variety of pain conditions. The oral and parenteral administration of magnesium via the intravenous, intrathecal, or epidural route may alleviate pain and perioperative anesthetic and analgesic requirements. These beneficial effects of magnesium therapy have also been reported in patients with neuropathic pain, such as malignancy-related neurologic symptoms, diabetic neuropathy, postherpetic neuralgia, and chemotherapy-induced peripheral neuropathy. In addition, magnesium treatment is reportedly able to alleviate fibromyalgia, dysmenorrhea, headaches, and acute migraine attacks. Although magnesium plays an evolving role in pain management, better understanding of the mechanism underlying its antinociceptive action and additional clinical studies is required to clarify its role as an adjuvant analgesic.

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Section: Magnesium and Perioperative Painmentioning

confidence: 95%

Section: Magnesium and Perioperative Painmentioning

confidence: 99%

Magnesium and Pain

Shin

Hwan

2020

Nutrients

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“…Administration of magnesium during surgery significantly improves postoperative pain control and reduces the dose of other analgesics. Magnesium reduces chronic, neuropathic (including diabetic neuropathy), and opioid-resistant pain [ 155 , 156 , 157 ].…”

Section: Postoperative Carementioning

confidence: 99%

Anaesthetic Approach to Enhanced Recovery after Surgery for Kidney Transplantation: A Narrative Review

Jaszczuk

Natarajan

Papalois

2022

JCM

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Enhanced recovery after surgery (ERAS) protocols are designed to reduce medical complications, the length of hospital stays (LoS), and healthcare costs. ERAS is considered safe and effective for kidney transplant (KTx) surgery. KTx recipients are often frail with multiple comorbidities. As these patients follow an extensive diagnostic pathway preoperatively, the ERAS protocol can ideally be implemented at this stage. Small singular changes in a long perioperative pathway can result in significant positive outcomes. We have investigated the current evidence for an ERAS pathway related to anaesthetic considerations in renal transplant surgery for adult recipients.

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“…It showed a greater degree of adverse effects, including increased incidences of neuropsychiatric symptoms. Patients in both groups found their treatments satisfactory and no adverse reactions were requiring additional treatment [30]. Due to the short study period (30 minutes), it is possible that adverse reactions were not identified as a result of this, although a power study was not designed to explore this.…”

Section: Psychotomimetic Effects Of Ketaminementioning

confidence: 99%

Ketamine: More than Just NMDA Blocker

Deka¹,

Dash²,

Bharali³

et al. 2022

Ketamine Revisited - New Insights Into NMDA Inhibitors

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Ketamine has been extensively used in the medical field for more than 50 years, but its exact mechanism of action remains unknown. It\'s used to induce dissociative anesthesia (a state of profound analgesia, amnesia with light sleep, immobility, and a sense of disassociation from one\'s own body and surroundings). Clinical studies on ketamine as a dissociative anesthetic, a model for psychosis, and as a rapidly acting antidepressant have sparked great interest in understanding its effects at the molecular and cellular level. It exerts uncompetitive inhibitory effects on NMDARs (N-Methyl-D-asperate) and may preferentially affect the function of NMDARs in interneurons. The hypnotic effects of this drug are attributed to its blocking action on NMDA and HCN1 receptors; however, both positive and negative modulation of choline, amine, and opioid systems appears to occur. It is likely that ketamine\'s effect on chronic pain and depression far outlasts its actual levels. This could be due to the hyperglutamatergic state induced by ketamine causing a secondary increase in structural synaptic connectivity. The authors of this review have attempted to highlight the action of ketamine not only on NMDA receptors but also on a variety of biochemical processes and functions found in intercellular environments, which may explain its diverse role in many diseases.

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Magnesium and Ketamine Reduce Early Morphine Consumption After Open Bariatric Surgery: a Prospective Randomized Double-Blind Study

Cited by 20 publications

References 40 publications

Magnesium and Pain

Magnesium and Pain

Anaesthetic Approach to Enhanced Recovery after Surgery for Kidney Transplantation: A Narrative Review

Ketamine: More than Just NMDA Blocker

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