Magnesium and Drugs

Gröber, Uwe

doi:10.3390/ijms20092094

Cited by 82 publications

(70 citation statements)

References 73 publications

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“…Secondary Mg deficiencies in older adults may be linked to the presence of several conditions and related polypharmacotherapy [ 34 ]. Diuretic therapy may cause excessive Mg urinary loss.…”

Section: Mg Deficits Associated With Agingmentioning

confidence: 99%

Magnesium in Aging, Health and Diseases

2021

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Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer’s disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.

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“…Secondary Mg deficiencies in older adults may be linked to the presence of several conditions and related polypharmacotherapy [ 34 ]. Diuretic therapy may cause excessive Mg urinary loss.…”

Section: Mg Deficits Associated With Agingmentioning

confidence: 99%

Magnesium in Aging, Health and Diseases

2021

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“…A classic example of tumor-induced secretory diarrhea is a carcinoid tumor, which is associated with serotonin syndrome. Other paraneoplastic syndromes can cause secretory diarrhea and subsequent hypomagnesemia 49,50 .…”

Section: Gastrointestinal Lossesmentioning

confidence: 99%

“…Supportive drugs commonly used in cancer cause hypomagnesemia (Table 3). Thiazide and loop diuretics are used in cancer patients and can cause hypomagnesemia via reduced paracellular Mg absorption via claudins 16 and 19 48,49 and downregulation of TRPM6 in DCT respectively 48,50 . Infectious disease is also a common complication of cancer and cancer therapy, and several therapies result in hypomagnesemia and are outlined in Tables 3 and 4.…”

Section: Renal Lossesmentioning

confidence: 99%

Hypomagnesemia in the Cancer Patient

et al. 2021

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Hypomagnesemia is a common medical problem that contributes to the morbidity and mortality of cancer patients. This review summarizes magnesium physiology and highlights the mechanisms underlying magnesium disturbances due to cancer and cancer treatment. The causes of hypomagnesemia can be categorized by the pathophysiological mechanism: decreased intake, transcellular shift, gastrointestinal losses, and kidney losses. Cancer patients are at risk for opportunistic infections, frequently experience cardiovascular complications, and often receive classes of medications that cause or exacerbate hypomagnesemia. Also, cancer-specific therapies are responsible for hypomagnesemia, including platinum-based chemotherapy, anti-EGFR monoclonal antibodies, human epidermal growth factor receptor-2 target inhibitors(HER2), and calcineurin inhibitors. Urinary indices, such as the fractional excretion of magnesium, can provide useful information about the etiology. The management of hypomagnesemia depends on the magnitude of hypomagnesemia and the underlying cause. We recommended checking serum magnesium at the beginning of treatment and as part of routine monitoring throughout cancer treatment. Opportunities exist for potential research and practice improvement, including further characterization of hypomagnesemia on the clinical impact on cancer outcomes, preventing hypomagnesemia in patients receiving high-risk anti-cancer agents, and developing effective therapeutic strategies.

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“…[4] Magnesium oxide is widely used as a laxative or antacid and is available over the counter in many developed countries. It is well known that magnesium laxatives interact with medicines, including oral antibiotics, bisphosphonates, digitalis, and iron supplements [1, 5]. Furthermore, it has been reported that long-term use of acid modifying medications such as proton pump inhibitor, histamine-2 receptor antagonist, and calcium carbonate can cause IDA [6].…”

Section: Discussionmentioning

confidence: 99%

Iron deficiency anemia induced by magnesium overuse: a case report

Sugimoto

Yamada

2019

BioPsychoSocial Med

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Background Although in vitro studies show that iron absorption can be inhibited by magnesium laxatives such as magnesium oxide, taking oral iron supplements with magnesium laxatives is not considered a clinical problem. Case presentation A 28-year-old woman diagnosed with anorexia nervosa who overused magnesium laxatives was admitted to our hospital to evaluate her refractory iron deficiency anemia (IDA), despite having taken oral iron replacement therapy for nine months. She had had amenorrhea for years and her fecal occult blood tests were negative. Furthermore, upper gastrointestinal endoscopy showed no suspected gastroduodenal bleeding or gastroenteritis. We considered her IDA to be induced by malabsorption of iron due to magnesium laxative overuse. Psychoeducational intervention stopped the overuse and oral iron replacement therapy was switched to the intravenous route. During outpatient follow-up, her anemia gradually improved; however, when her magnesium laxative overuse began again, her hemoglobin levels suddenly decreased. Conclusions Clinicians should be attentive to the interactions between iron and magnesium laxatives.

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Magnesium and Drugs

Cited by 82 publications

References 73 publications

Magnesium in Aging, Health and Diseases

Magnesium in Aging, Health and Diseases

Hypomagnesemia in the Cancer Patient

Iron deficiency anemia induced by magnesium overuse: a case report

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