Magnesium and diabetes mellitus: Their relation

Sales, Cristiane Hermes; Pedrosa, Lucía

doi:10.1016/j.clnu.2006.03.003

Cited by 158 publications

(121 citation statements)

References 49 publications

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“…It serves as a co-factor for all enzymatic reactions that require ATP and as a key component in various reactions that require kinases. It is also an essential enzyme activator for neuromuscular excitability and cell permeability, a regulator of ion channels and mitochondrial function, a critical element in cellular proliferation and apoptosis, and an important factor in both cellular and humoral immune reactions (reviewed in references [2][3][4][5][6]). …”

Section: Magnesium and Cell Physiologymentioning

confidence: 99%

“…Finally, there also are data to suggest the association between hypomagnesemia and other diabetic complications, including dyslipidemia and neurologic abnormalities (6). Because hypomagnesemia has been linked to various microand macrovascular complications, a better understanding of Mg metabolism and efforts to minimize hypomagnesemia in the routine management of diabetes are warranted.…”

Section: Hypomagnesemia In the Clinical Settingmentioning

confidence: 99%

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Hypomagnesemia in Patients with Type 2 Diabetes

Pham

Pham³

et al. 2007

Clinical Journal of the American Society of Nephrology

341

325

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Hypomagnesemia has been reported to occur at an increased frequency among patients with type 2 diabetes compared with their counterparts without diabetes. Despite numerous reports linking hypomagnesemia to chronic diabetic complications, attention to this issue is poor among clinicians. This article reviews the literature on the metabolism of magnesium, incidence of hypomagnesemia in patients with type 2 diabetes, implicated contributing factors, and associated complications. Hypomagnesemia occurs at an incidence of 13.5 to 47.7% among patients with type 2 diabetes. Poor dietary intake, autonomic dysfunction, altered insulin metabolism, glomerular hyperfiltration, osmotic diuresis, recurrent metabolic acidosis, hypophosphatemia, and hypokalemia may be contributory. Hypomagnesemia has been linked to poor glycemic control, coronary artery diseases, hypertension, diabetic retinopathy, nephropathy, neuropathy, and foot ulcerations. The increased incidence of hypomagnesemia among patients with type 2 diabetes presumably is multifactorial. Because current data suggest adverse outcomes in association with hypomagnesemia, it is prudent to monitor magnesium routinely in this patient population and treat the condition whenever possible.

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Section: Magnesium and Cell Physiologymentioning

confidence: 99%

Section: Hypomagnesemia In the Clinical Settingmentioning

confidence: 99%

Hypomagnesemia in Patients with Type 2 Diabetes

Pham

Pham³

et al. 2007

Clinical Journal of the American Society of Nephrology

341

325

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“…Low serum concentrations of magnesium ion were related to an increased risk of cardiovascular diseases (Kupetsky-Rincon and Uitto 2012). Additionally, hypomagnesemia due to low serum magnesium concentration is also associated with insulin resistance and diabetes mellitus (Sales and Pedrosa Lde 2006). Indeed, sufficient magnesium intake is known to reduce the development of diabetes mellitus (Joo et al 2016).…”

Section: +mentioning

confidence: 99%

Eye and skin irritation tests to assess the safety of Jeju saline groundwater

Cho

Joo

Park

et al. 2017

JABC

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Saline groundwater was obtained from a 100-m deep basalt layer into which seawater had infiltrated. This groundwater is known to contain various minerals. Like deep seawater, saline groundwater is expected to have various applications due to the presence of biologically beneficial minerals. In Korea, saline groundwater is mainly obtained from the coastal area of Jeju. Before applying saline groundwater to various products, however, its biological safety needs to be examined. In the present study, skin and eye irritation tests were performed to assess the safety of saline groundwater according to the guidelines of the Korea Food and Drug Administration. When compared to control, Jeju saline groundwater showed no level of eye and skin irritation. These results suggest that Jeju saline groundwater induces no irritation, and is therefore sufficiently safe to be applied to the eye and skin of people.

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“…Hence, magnesium ion is an essential mineral element in human and animal nutrition. It is also used as a metallotherapeutic agent to treat various diseases such as asthma, arrhythmias, acute myocardial infarction, gestational hypertension, preeclampsia and eclampsia [1][2][3][4][5][6][7]. Perioperative magnesium supplementation is found to be very useful in the management of postoperative pain by inhibiting postoperative hypomagnesia as well as reducing the incidence of postoperative shivering [8,9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect<sup>®</sup>)

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

JDDMC

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Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the physicochemical, structural, thermal and behavioral properties using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts -one part was control, while another part was treated with The Trivedi Effect ® -Energy of Consciousness Healing Treatment remotely by seven renowned Biofield Energy Healers and defined as the Biofield Energy Treated sample. The PXRD analysis exhibited significant alteration of the crystal morphology of the treated sample compared with the control sample. The crystallite size of the treated sample was remarkably changed from range -69.99% to 71.40% compared with the control sample. The average crystallite size was significantly decreased in the treated sample by 13.61% compared with the control sample. Particle size analysis revealed that the particle size in the treated sample at d 10 , d 50 , and d 90 value was significantly decreased by 5.19%, 26.77%, and 18.22%, respectively compared with the control sample. The treated sample's surface area was significantly enhanced (12.82%) compared with the control sample. The FT-IR and UV-vis analysis showed that the structure of the magnesium gluconate remained the same in both the treated and control samples. The TGA analysis revealed the four steps thermal degradation of the both samples and the total weight loss of the Biofield Energy Treated sample was increased by 0.55% compared with the control sample. The DSC analysis revealed that the melting temperature of the treated sample (171.72°C) was increased by 0.21% compared with the control sample (171.36°C). The latent heat of fusion was increased by 4.66% in the treated sample compared with the control sample. This result indicated that the thermal stability of treated sample was improved compared with the control sample. The current study infers that The Trivedi Effect ® -Biofield Energy Healing might lead to a new polymorphic form of magnesium gluconate, which would be more soluble, bioavailable, and thermally stable compared with the untreated compound. Hence, the treated magnesium gluconate would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic responses against inflammatory diseases, immunological disorders, stress, aging and other chronic infections.

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Magnesium and diabetes mellitus: Their relation

Cited by 158 publications

References 49 publications

Hypomagnesemia in Patients with Type 2 Diabetes

Hypomagnesemia in Patients with Type 2 Diabetes

Eye and skin irritation tests to assess the safety of Jeju saline groundwater

Evaluation of Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect<sup>®</sup>)

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Magnesium and diabetes mellitus: Their relation

Cited by 158 publications

References 49 publications

Hypomagnesemia in Patients with Type 2 Diabetes

Hypomagnesemia in Patients with Type 2 Diabetes

Eye and skin irritation tests to assess the safety of Jeju saline groundwater

Evaluation of Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;)

Contact Info

Product

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Evaluation of Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate Treated with Energy of Consciousness (The Trivedi Effect<sup>®</sup>)