Magnesium, Aging, and the Elderly Patient

Davidović, Mladen; Trailov, Dejan; Milosević, D; Radosavljević, Branimir; Milanović, Pavle; Djurica, Sneẑana; Loncar-Stevanović, H; Stević, Radmila

doi:10.1100/tsw.2004.114

Cited by 7 publications

(10 citation statements)

References 13 publications

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“…It has been suggested that low serum Mg level could be a marker of insulin resistance [9]. Not only is hypomagnesemia more prevalent in elderly subjects but the effects of changes in Mg levels are also more prominent in this age group [11,12].…”

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confidence: 99%

Low Serum Magnesium Levels in Elderly Subjects with Metabolic Syndrome

Ghasemi

Zahediasl

Syedmoradi

et al. 2009

Biol Trace Elem Res

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This study aims at determining possible association between serum magnesium (Mg) concentrations and metabolic syndrome (MetS) in elderly subjects. Subjects were 137 men and women aged 60 to 90 years, selected from among participants of the Tehran Lipid and Glucose Study after excluding those taking medications for hypertension and dyslipidemia. Serum Mg levels were measured by atomic absorption spectrometry and MetS was defined according to ATP III criteria. The overall prevalence of MetS was 43.8%. Among MetS components, only plasma glucose showed a negative correlation with serum Mg concentrations (r = -0.194, p = 0.024). Subjects with MetS had significantly lower serum Mg concentrations compared with non-MetS ones (2.09 +/- 0.03 vs. 2.18 +/- 0.03 mg/dL, p = 0.033) even after adjustments with MetS components except for hyperglycemia (2.04 +/- 0.06 vs. 2.20 +/- 0.05 mg/dL, p = 0.011). However, after adjustment for hyperglycemia per se or along with the other MetS components, the significant difference between serum Mg levels in subjects with and without MetS disappeared. In conclusion, serum Mg level is diminished in elderly subjects with MetS, and hyperglycemia may play dominant role in this decrease; however, the results do not clarify whether the low serum Mg level is a consequence of hyperglycemia or is a risk factor contributing to its development.

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confidence: 99%

Low Serum Magnesium Levels in Elderly Subjects with Metabolic Syndrome

Ghasemi

Zahediasl

Syedmoradi

et al. 2009

Biol Trace Elem Res

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“…Aging represents a major risk factor for magnesium (Mg) deficit. Several alterations of Mg status have been identified in the elderly [1][2][3][4][5][6][7][8][9][10][11][12][13]. Total body Mg content tends to decrease with age, with bone being the main storage compartment of body Mg. Of the 21-28 g of Mg present in the adult human body, about 55-65% is in the mineral phase in the skeleton, 34-44% in the intracellular space, and only 1% in the extracellular fluid [14].…”

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confidence: 99%

Magnesium homeostasis and aging

Barbagallo

Belvedere²,

Lj³

2009

Magnesium Research

177

132

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Aging is very often associated with magnesium (Mg) deficit. Total plasma magnesium concentrations are remarkably constant in healthy subjects throughout life, while total body Mg and Mg in the intracellular compartment tend to decrease with age. Dietary Mg deficiencies are common in the elderly population. Other frequent causes of Mg deficits in the elderly include reduced Mg intestinal absorption, reduced Mg bone stores, and excess urinary loss. Secondary Mg deficit in aging may result from different conditions and diseases often observed in the elderly (i.e. insulin resistance and/or type 2 diabetes mellitus) and drugs (i.e. use of hypermagnesuric diuretics). Chronic Mg deficits have been linked to an increased risk of numerous preclinical and clinical outcomes, mostly observed in the elderly population, including hypertension, stroke, atherosclerosis, ischemic heart disease, cardiac arrhythmias, glucose intolerance, insulin resistance, type 2 diabetes mellitus, endothelial dysfunction, vascular remodeling, alterations in lipid metabolism, platelet aggregation/thrombosis, inflammation, oxidative stress, cardiovascular mortality, asthma, chronic fatigue, as well as depression and other neuropsychiatric disorders. Both aging and Mg deficiency have been associated to excessive production of oxygen-derived free radicals and lowgrade inflammation. Chronic inflammation and oxidative stress are also present in several age-related diseases, such as many vascular and metabolic conditions, as well as frailty, muscle loss and sarcopenia, and altered immune responses, among others. Mg deficit associated to aging may be at least one of the pathophysiological links that may help to explain the interactions between inflammation and oxidative stress with the aging process and many age-related diseases.

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“…In particular, in healthy elderly (N65 years old) the levels of Mg-ions and intracellular free Mg are reduced with respect to young controls (b 65 years old), while the total serum Mg remained unchanged (Barbagallo et al, 2000(Barbagallo et al, , 2009. Many studies reported the same observation of unaltered values of Mg during aging (Davidovic et al, 2004;Del Corso et al, 2000;Mataix et al, 2006). In the study of Sfar et al (2012) Mg mean concentrations did not show any significant variation relatively to age (30-60 years, 20.51 μg/ml; 65-85 years: 20.86 μg/ml).…”

Section: Magnesiummentioning

confidence: 76%

“…The Mg deficiency can cause oxidative damage and peroxidation, insulin resistance, disordered Mg metabolism in the bones, adrenaline hyperactivity and illness (diabetes, for example). In addition, Mg deficiency influences the DNA repair, lead to genetic instability and accelerated aging, affects different cell functions and initiates stress-induced premature senescence (Davidovic et al, 2004;Killilea and Maier, 2008). Manganese is indispensable for normal development and body functions of all mammals.…”

Section: Introductionmentioning

confidence: 98%