Magnesium Administration in Chronic Kidney Disease

Vermeulen, Emma A.; Vervloet, Marc G.

doi:10.3390/nu15030547

Cited by 9 publications

(6 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, our study only found a positive correlation between serum K and CKD, which may be attributed to disparities in study populations, regions, and statistical methods. Prior research has consistently shown that serum Mg concentration is lower in CKD patients compared to controls and is negatively correlated with CKD development, consistent with the findings of Vermeulen and Vervloet ( 20 ). As an essential trace element, the positive influence of Se supplementation on CKD pathogenesis reaffirms our results of this study ( 21 – 23 ).…”

Section: Discussionsupporting

confidence: 85%

Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease

Wu,

Hou,

Qin

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundPrevious studies have identified several genetic and environmental risk factors for chronic kidney disease (CKD). However, little is known about the relationship between serum metals and CKD risk.MethodsWe investigated associations between serum metals levels and CKD risk among 100 medical examiners and 443 CKD patients in the medical center of the First Hospital Affiliated to China Medical University. Serum metal concentrations were measured using inductively coupled plasma mass spectrometry (ICP-MS). We analyzed factors influencing CKD, including abnormalities in Creatine and Cystatin C, using univariate and multiple analysis such as Lasso and Logistic regression. Metal levels among CKD patients at different stages were also explored. The study utilized machine learning and Bayesian Kernel Machine Regression (BKMR) to assess associations and predict CKD risk based on serum metals. A chained mediation model was applied to investigate how interventions with different heavy metals influence renal function indicators (creatinine and cystatin C) and their impact on diagnosing and treating renal impairment.ResultsSerum potassium (K), sodium (Na), and calcium (Ca) showed positive trends with CKD, while selenium (Se) and molybdenum (Mo) showed negative trends. Metal mixtures had a significant negative effect on CKD when concentrations were all from 30th to 45th percentiles compared to the median, but the opposite was observed for the 55th to 60th percentiles. For example, a change in serum K concentration from the 25th to the 75th percentile was associated with a significant increase in CKD risk of 5.15(1.77,8.53), 13.62(8.91,18.33) and 31.81(14.03,49.58) when other metals were fixed at the 25th, 50th and 75th percentiles, respectively.ConclusionsCumulative metal exposures, especially double-exposure to serum K and Se may impact CKD risk. Machine learning methods validated the external relevance of the metal factors. Our study highlights the importance of employing diverse methodologies to evaluate health effects of metal mixtures.

show abstract

Section: Discussionsupporting

confidence: 85%

Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease

Wu,

Hou,

Qin

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Approximately 50-60% of magnesium is sequestered in the bone as hydroxyapatite crystal 7) . Only a small fraction of magnesium is stored in the extracellular compartment, approximately 60% of which exists in the biologically active, free form 8) . The normal serum magnesium concentration is 1.7-2.4 mg/dL 6) .…”

Section: Discussionmentioning

confidence: 99%

Fatal Hypermagnesemia in Patients Taking Magnesium Hydroxide

Jou,

Kim,

Choi

et al. 2023

Electrolyte Blood Press

View full text Add to dashboard Cite

Hypermagnesemia is a rare but potentially fatal electrolyte disorder often overlooked because of its unfamiliarity. Magnesium is regulated through a balance of bone, intestinal absorption, and renal excretion. Hypermagnesemia typically arises from excessive magnesium intake or reduced renal excretion; however, it also occurs in patients with normal kidney function. Herein, we report two cases of hypermagnesemia in patients taking magnesium hydroxide for constipation. The first case involved an 82-year-old woman with end-stage renal disease who developed metabolic encephalopathy due to hypermagnesemia, after taking 3,000 mg of magnesium hydroxide daily for constipation. Her magnesium level was 9.9 mg/dL. Her treatment involved discontinuing magnesium hydroxide and continuing hemodialysis, which led to her recovery. In the second case, a 50-year-old woman with a history of cerebral hemorrhage and mental retardation developed hypermagnesemia despite having normal renal function. She was also taking magnesium hydroxide for constipation, and her magnesium level was 11.0 mg/dL. She experienced cardiac arrest while preparing for continuous renal replacement therapy (CRRT). After achieving return of spontaneous circulation, CRRT was initiated, and her magnesium level showed a decreasing trend. However, vital signs and lactate levels did not recover, leading to death. These cases highlight the importance of prompt diagnosis and intervention for hypermagnesemia and the need to regularly monitor magnesium levels in individuals receiving magnesium-containing preparations, especially those with impaired kidney function.

show abstract

“…Pada CKD, ginjal kehilangan kemampuannya untuk mengeluarkan zat-zat sisa dari metabolisme, termasuk asam urat dan urea. Akumulasi zat-zat ini dalam darah dapat menyebabkan pergeseran asam basa (Vermeulen and Vervloet, 2023), yang (Szlagor et al, 2023). Ginjal yang tidak berfungsi dengan baik tidak dapat membuang kelebihan cairan dari tubuh dengan efisien.…”

Section: B Pembahasanunclassified

Asuhan Keperawatan Pasien Penurunan Kesadaran

Daeli,

Solehudin,

Suryadi

2024

Bidang Kesehatan

View full text Add to dashboard Cite

Nursing care for patients with decreased consciousness is not only related to medical monitoring, but also involves holistic aspects such as emotional support and effective communication. This study aims to explain in depth nursing care for patients with decreased consciousness, including the challenges that nurses may face, effective intervention strategies, and the important role of nurses in improving the patient's quality of life. The method in this research uses a case study. The research method is nursing care which includes assessment, diagnosis, intervention, implementation and evaluation of nursing in 1 (one) shift. The results of the assessment showed that the patient's admission history arrived at the Emergency Room with a medical diagnosis of Chronic Kidney Disease. When the Somnolent consciousness assessment was carried out, GCS 10, the patient experienced respiratory failure, a ventilator was installed, OPA, NRM 10 lpm, an NGT was installed, the NGT fluid was yellow. The patient had a Folley catheter installed, the urine color was clear yellow. Physical examination; Blood pressure 124/82 mmHg, pulse 104x/minute, RR 13x/minute, temperature 370c, rhonchi wet. The main nursing problem found in these patients was gas exchange disorders. Nursing actions include ensuring the patient's airway remains open, providing respiratory assistance or mechanical ventilation, monitoring vital signs, such as blood pressure, pulse, breathing and body temperature, collaborating with health team members, such as doctors and therapists, to plan and provide effective care.

show abstract

Magnesium Administration in Chronic Kidney Disease

Cited by 9 publications

References 104 publications

Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease

Comparative mathematical modeling of causal association between metal exposure and development of chronic kidney disease

Fatal Hypermagnesemia in Patients Taking Magnesium Hydroxide

Asuhan Keperawatan Pasien Penurunan Kesadaran

Contact Info

Product

Resources

About