Magnesidin, a Novel Magnesium-Containing Antibiotic

Gandhi, N. M.; Nazareth, Jardim; Divekar, P. V.; Köhl, H.; Souza, N. J. De

doi:10.7164/antibiotics.26.797

Cited by 33 publications

(7 citation statements)

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“…from the same sample, suggesting that prodigiosin might act as a antibiotic in the natural environment. Interestingly, the prodigiosin producing V. gazogenes also produced the unique magnesium containing antibiotic, magnesidin ( 16 ) (Figure 7) [55,121–123]. …”

Section: Natural Product Production By Members Of the Vibrionaceaementioning

confidence: 99%

Production of Bioactive Secondary Metabolites by Marine Vibrionaceae

2011

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Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to produce bioactive secondary metabolites and studies have been limited to only a few species. Most of the compounds isolated from vibrios so far are non-ribosomal peptides or hybrids thereof, with examples of N-containing compounds produced independent of nonribosomal peptide synthetases (NRPS). Though covering a limited chemical space, vibrios produce compounds with attractive biological activities, including antibacterial, anticancer, and antivirulence activities. This review highlights some of the most interesting structures from this group of bacteria. Many compounds found in vibrios have also been isolated from other distantly related bacteria. This cosmopolitan occurrence of metabolites indicates a high incidence of horizontal gene transfer, which raises interesting questions concerning the ecological function of some of these molecules. This account underlines the pending potential for exploring new bacterial sources of bioactive compounds and the challenges related to their investigation.

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Section: Natural Product Production By Members Of the Vibrionaceaementioning

confidence: 99%

Production of Bioactive Secondary Metabolites by Marine Vibrionaceae

2011

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“…The role of metal binding in the bactericidal activity of tetramic acids is unclear, with some tetramic acids displaying increased toxicity as a metal complex, whereas in others, the toxicity is attenuated by chelation of a metal ion (24). Given this disparity, we investigated the ability of AHL-derived tetramic acid 4 to complex metals to evaluate the potential bioactivity of these complexes.…”

Section: -(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-24-dimentioning

confidence: 99%

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo- N -acylhomoserine lactones

Kaufmann

Sartorio

Lee

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

319

349

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Bacteria use small diffusible molecules to exchange information in a process called quorum sensing. An important class of autoinducers used by Gram-negative bacteria is the family of N-acylhomoserine lactones. Here, we report the discovery of a previously undescribed nonenzymatically formed product from N-(3-oxododecanoyl)-L-homoserine lactone; both the N-acylhomoserine and its novel tetramic acid degradation product, 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione, are potent antibacterial agents. Bactericidal activity was observed against all tested Gram-positive bacterial strains, whereas no toxicity was seen against Gram-negative bacteria. We propose that Pseudomonas aeruginosa utilizes this tetramic acid as an interference strategy to preclude encroachment by competing bacteria. Additionally, we have discovered that this tetramic acid binds iron with comparable affinity to known bacterial siderophores, possibly providing an unrecognized mechanism for iron solubilization. These findings merit new attention such that other previously identified autoinducers be reevaluated for additional biological functions.tetramic acid ͉ bactericidal agents ͉ evolution

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“…and Bacillus sp. [255]. Another bioactive compound, namely, 2, 4-diacetylphloroglucinol (Figure 14, Compound 45), was isolated from a novel Pseudomonas sp.…”

Section: Antimicrobial Potential Of Bacteria Associated With Marine Seaweedsmentioning

confidence: 99%

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

et al. 2021

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The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, and viruses. Because of the burgeoning growth of microbes with antimicrobial-resistant traits, there is a dire need to identify and develop novel and effective antimicrobial agents to treat infections from antimicrobial-resistant strains. The marine environment is rich in ecological biodiversity and can be regarded as an untapped resource for prospecting novel bioactive compounds. Therefore, exploring the marine environment for antimicrobial agents plays a significant role in drug development and biomedical research. Several earlier scientific investigations have proven that bacterial diversity in the marine environment represents an emerging source of structurally unique and novel antimicrobial agents. There are several reports on marine bacterial secondary metabolites, and many are pharmacologically significant and have enormous promise for developing effective antimicrobial drugs to combat microbial infections in drug-resistant pathogens. In this review, we attempt to summarize published articles from the last twenty-five years (1996–2020) on antimicrobial secondary metabolites from marine bacteria evolved in marine environments, such as marine sediment, water, fauna, and flora.

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Magnesidin, a Novel Magnesium-Containing Antibiotic

Cited by 33 publications

References 1 publication

Production of Bioactive Secondary Metabolites by Marine Vibrionaceae

Production of Bioactive Secondary Metabolites by Marine Vibrionaceae

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo- N -acylhomoserine lactones

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

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