Magic Angle Spinning NMR Spectroscopy: A Versatile Technique for Structural and Dynamic Analysis of Solid-Phase Systems

Abstract

Magic Angle Spinning (MAS) NMR spectroscopy is a powerful method for analysis of a broad range of systems, including inorganic materials, pharmaceuticals, and biomacromolecules. The recent developments in MAS NMR instrumentation and methodologies opened new vistas to atomic-level characterization of a plethora of chemical environments previously inaccessible to analysis, with unprecedented sensitivity and resolution.

RF inhomogeneity and how it controls CPMAS

“…Without this seminal development solid-state NMR would not have had the broad impact on the applications to analysis of a wide range materials in different branches of chemistry, physics, biological sciences, materials sciences, engineering, and others [2]. At first this experiment was viewed with skepticism because MAS decouples the heteronuclear dipolar interaction that is instrumental in the CP-based magnetization transfer.…”

Dynamic Nuclear Polarization as an Enabling Technology for Solid State Nuclear Magnetic Resonance Spectroscopy

“…1234567891011121314151617181920212223 A particular strength of MAS ssNMR is it can be applied to heterogeneous systems, which are not amenable to study by other high-resolution experimental techniques due to sample characteristics. For example biomolecular assemblies, such as membrane proteins, are often not tractable for solubilization, a requisite for standard solution state NMR experiments, or crystallization, as needed for diffraction studies.…”

A Guide to Brighter Phosphors‐Linking Luminescence Properties to Doping Homogeneity Probed by NMR

“…[17][18][19][20] Solid state NMR has been reported to be helpful for studying paramagnetic systems. [21][22][23][24][25][26] Especially, the distribution of paramagnetic dopants can be investigated by the spin-lattice relaxation time, [27][28][29][30] hyperfine shifts [31,32] and the line-broadening effect. [27,33,34] Homogeneous distributions of Tb 3 + and Eu 3 + were shown to be correlated to NMR line broadening and positively related to the brightness of phosphors.…”

“…Solid state NMR has been reported to be helpful for studying paramagnetic systems . Especially, the distribution of paramagnetic dopants can be investigated by the spin‐lattice relaxation time, hyperfine shifts and the line‐broadening effect .…”