MAGI-1 Modulates AMPA Receptor Synaptic Localization and Behavioral Plasticity in Response to Prior Experience

Emtage, Lesley; Chang, Howard C.; Tiver, Rebecca; Rongo, Christopher

doi:10.1371/journal.pone.0004613

Cited by 43 publications

(41 citation statements)

References 45 publications

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“…They trained L1 larvae with seven blocks (separated by 1 h) of 15 taps at a 60-sec ISI. In contrast to Ebrahimi and Rankin (2007), Emtage et al (2009) found that young adults stimulated in L1 had a decreased TWR magnitude, as measured by the number of quarter body bends executed in the response. This discrepancy may be the result of a different training regime, rearing condition (208C vs. 258C), behavioral measure, or time of training/testing.…”

Section: Long-term Memorymentioning

confidence: 58%

“…This study demonstrates that larval stimulation can affect adult behavior, but the effect depends on the timing and pattern of stimulation. Emtage et al (2009) also studied the effects of early patterned stimulation on adult behavior and identified a gene mediating changes in AMPA receptor localization. They trained L1 larvae with seven blocks (separated by 1 h) of 15 taps at a 60-sec ISI.…”

Section: Long-term Memorymentioning

confidence: 99%

“…This discrepancy may be the result of a different training regime, rearing condition (208C vs. 258C), behavioral measure, or time of training/testing. Emtage et al (2009) also looked at habituation and found that young adults stimulated in L1 stopped responding to mechanical stimuli more quickly than controls (a measure of response frequency rather than magnitude). Long-term memory of early training required glr-1, as well as a second AMPA-type glutamate receptor subunit, glr-2.…”

Section: Long-term Memorymentioning

confidence: 99%

“…Long-term memory of early training required glr-1, as well as a second AMPA-type glutamate receptor subunit, glr-2. Emtage et al (2009) reported a significant increase in the number of GLR-2::GFP clusters in the anterior ventral nerve cord of young adults stimulated in L1 and showed that the scaffolding molecule, MAGI-1, interacted with the intracellular domain of GLR-2 to regulate AMPA receptor localization following habituation training.…”

Section: Long-term Memorymentioning

confidence: 99%

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An elegant mind: Learning and memory in Caenorhabditis elegans

Ardiel¹,

Rankin²

2010

Learn. Mem.

275

191

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This article reviews the literature on learning and memory in the soil-dwelling nematode Caenorhabditis elegans. Paradigms include nonassociative learning, associative learning, and imprinting, as worms have been shown to habituate to mechanical and chemical stimuli, as well as learn the smells, tastes, temperatures, and oxygen levels that predict aversive chemicals or the presence or absence of food. In each case, the neural circuit underlying the behavior has been at least partially described, and forward and reverse genetics are being used to elucidate the underlying cellular and molecular mechanisms. Several genes have been identified with no known role other than mediating behavior plasticity.Historically, it was believed that even if they were capable of learning, the nervous systems of invertebrates were too different to be instructive on human cognition. In the 1960s, Kandel and colleagues began studying learning in the marine mollusc Aplysia (Kandel and Tauc 1965). Using this system, they were able to relate behavioral plasticity to changes at specific synapses of identified neurons, and began a biochemical analysis of these neuronal changes, uncovering a role for cAMP, PKA, and CREB. In the 1970s, Benzer and colleagues began a genetic dissection of learning in the fruit fly Drosophila melanogaster (Quinn et al. 1974;Dudai et al. 1976). They established an associative learning assay (Quinn et al. 1974) and conducted a forward genetic screen, identifying the first learning mutant, dunce (Dudai et al. 1976). Since then, many genes have been cloned, and the biological basis of learning has proven to be highly conserved (Barco et al. 2006;Skoulakis and Grammenoudi 2006). Today there is no question as to the relevance of invertebrate research in the field of learning and memory.At about the same time that Kandel was beginning his work with Aplysia, Sydney Brenner chose Caenorhabditis elegans as the organism in which to study development and the nervous system (Brenner 1974). Today this transparent nematode is the world's best understood animal. It's small size ( 1 mm), short life cycle (,3 d), and ease of cultivation make it perfect for the laboratory, and its mode of reproduction is ideal for genetic analysis-selffertilizing hermaphrodites can be easily inbred or crossed with males. The genome has been mapped and sequenced, and there are thousands of mutants and RNAi constructs readily available for researchers. Furthermore, C. elegans has an invariant cell lineage and relatively simple morphology-959 cells make up the entire adult hermaphrodite (Sulston and Horvitz 1977;Sulston et al. 1983). Using serial section electron micrographs, White et al. (1986) were able to construct a neural wiring diagram of the hermaphrodite's 302 neurons. They found about 5000 chemical synapses, 600 gap junctions, and 2000 neuromuscular junctions, the location of which were fairly consistent between animals. With its invariant cell lineage and reproducible connectome, C. elegans was initially viewed as a genetically hardwired ...

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Section: Long-term Memorymentioning

confidence: 58%

Section: Long-term Memorymentioning

confidence: 99%

Section: Long-term Memorymentioning

confidence: 99%

Section: Long-term Memorymentioning

confidence: 99%

See 2 more Smart Citations

An elegant mind: Learning and memory in Caenorhabditis elegans

Ardiel¹,

Rankin²

2010

Learn. Mem.

275

191

View full text Add to dashboard Cite

show abstract

“…SNPs of MAGI2 have been associated with performance in the Wisconsin Sorting Card Test (WCST) in patients with SCZ (Koide et al, 2012), whereas in animal models it was shown to modulate long-term memory and associative learning (Emtage et al, 2009;Stetak et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity

Gadelha

Coleman

Breen

et al. 2016

Schizophrenia Research

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Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffolding proteins of metabotropic glutamate receptors in Caenorhabditis elegans

2018

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The metabotropic glutamate receptors (mGluRs) are a class of G-protein-coupled receptor that undergo extensive interactions with scaffolding proteins, and this is intrinsic to their function as an important group of neuromodulators at glutamatergic synapses. The Caenorhabditis elegans nervous system expresses three metabotropic glutamate receptors, MGL-1, MGL-2 and MGL-3. Relatively little is known about how the function and signalling of these receptors is organised in C. elegans. To identify proteins that scaffold the MGL-1 receptor, we have conducted a yeast two-hybrid screen. Three of the interacting proteins, MPZ-1, NRFL-1 and PTP-1, displayed motifs characteristic of mammalian mGluR scaffolding proteins. Using cellular co-expression criterion, we show mpz-1 and ptp-1 exhibited overlapping expression patterns with subsets of mgl-1 neurons. This included neurones in the pharyngeal nervous system that control the feeding organ of the worm. The mGluR agonist L-CCG-I inhibits the activity of this network in wild-type worms, in an MGL-1 and dose-dependent manner. We utilised L-CCG-I to identify if MGL-1 function was disrupted in mutants with deletions in the mpz-1 gene. The mpz-1 mutants displayed a largely wild-type response to L-CCG-I, suggesting MGL-1 signalling is not overtly disrupted consistent with a non-obligatory modulatory function in receptor scaffolding. The selectivity of the protein interactions and overlapping expression identified here warrant further investigation of the functional significance of scaffolding of metabotropic glutamate receptor function.

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MAGI-1 Modulates AMPA Receptor Synaptic Localization and Behavioral Plasticity in Response to Prior Experience

Cited by 43 publications

References 45 publications

An elegant mind: Learning and memory in Caenorhabditis elegans

An elegant mind: Learning and memory in Caenorhabditis elegans

Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity

Yeast two-hybrid screening identifies MPZ-1 and PTP-1 as candidate scaffolding proteins of metabotropic glutamate receptors in Caenorhabditis elegans

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