Maggot therapy for the treatment of diabetic foot ulcers.

Mumcuoglu, Kosta Y.; Ingber, Arieh; Gilead, Leon; Stessman, Jochanan; Friedmann, Reuven; Schulman, Harold; Bichucher, H; Ioffe-Uspensky, I; Miller, Jacqueline M.; Galun, Rachel; I, Raz

doi:10.2337/diacare.21.11.2030

Cited by 79 publications

(65 citation statements)

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“…The larvae disinfect the wound with the enzymes they produce and stimulate tissue granulation. [21] In addition, the digestive and hemolymph excretions of the larvae stimulate epidermal growth factor (EGF) and, thus, fibroblast cells, leading to fibroblast tissue growth. [18] Larval extracts and EGF have been shown to stimulate fibroplasia through different mechanisms and to have a synergistic effect.…”

Section: Discussionmentioning

confidence: 99%

“…Larvae treatment is much more rapid and inexpensive than traditional treatment and is, therefore, an alternative treatment with favorable costs. [21][22][23] The larvae placed on the wound secrete many anti-bacterial and antiLeishmanial substances, while transitioning from Stage II to Stage III. The larvae disinfect the wound with the enzymes they produce and stimulate tissue granulation.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of pressure ulcers with larvae of Lucilia sericata

Polat

Kutlubay

Sirekbasan

et al. 2017

Turk J Phys Med Rehab

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Objectives: This study aims to investigate the use of the Lucilia sericata larvae in patients with decubitus ulcers resistant to hyperbaric oxygen treatment, vacuum-assisted closure, surgical debridement, and other conventional therapies. Patients and methods:A total of 36 patients (21 females, 15 males; mean age 63.7 years; range 16 to 90 years) who were admitted to our hospital for decubitus ulcers between February 2011 and July 2016 were included in our study. All patients had one or more lesions in the sacral region, trochanteric area, dorsal region, or on the heel of the foot. Nine patients had spinal cord injuries, six of them were injured during a car accident, and three of them had spinal cord injuries due to gunshot. One patient had concomitant lung cancer, one had heart failure, and two patients had a diagnosis of multiple sclerosis. Thirty three of 36 patients were admitted to the wound therapy unit within the department of emergency medicine, and three were admitted to the physical therapy and rehabilitation clinic. For each patient, Lucilia sericata maggots were applied on the lesions for 72 hours and, then, washed away. This procedure was repeated two times a week. Twenty nine patients (78.9%) had four to six sessions and seven patients (21.1%) had eight to 12 sessions.Results: Twenty nine lesions (78.9%) were Grade 2 and 3 and were completely healed after four to eight treatment sessions, while seven lesions (21.1%) were completely cured at the end of 10 to 14 sessions. There was complete clearance of necrotic debris at the end of two sessions within the first week for 15 lesions, whereas 10 lesions (27.8%) were cured after four sessions within two weeks, seven lesions (19.4%) within five sessions after three weeks, and four lesions (11.1%) were treated at the end of seven sessions for four weeks. All the necrotic crusts over the surface of the ulcers were cleaned and bad odor of the lesions disappeared. Conclusion:Lucilia sericata larvae debridement is a rapid and effective treatment option for the management of chronic decubitus ulcers which are resistant to conventional therapies and other treatment modalities such as hyperbaric oxygen, vacuum-assisted closure, and surgical debridement.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Treatment of pressure ulcers with larvae of Lucilia sericata

Polat

Kutlubay

Sirekbasan

et al. 2017

Turk J Phys Med Rehab

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“…4) While its therapeutic effects vary among reports, MDT has been effective in about 80%-90% of patients. [5][6][7] MDT has also been reported to be effective for the treatment of pressure ulcer, 8) burn injury, 9) osteomyelitis, 10) diabetic ulcer, 11) ulcers associated with venous stasis, 12) MRSA infection, 13) and chronic intractable ulcers. 14) Age has been suggested as a factor that affects the therapeutic effect of MDT, 15) but these factors have not been evaluated in detail.…”

Section: Disclosure Statementmentioning

confidence: 99%

Maggot Debridement Therapy for Peripheral Arterial Disease

Igari

Toyofuku

Uchiyama

et al. 2013

Annals of Vascular Diseases

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“…1) is the salvage therapy for cases where the poor blood supply to the deep wounds and subsequent inability of immunological mediators and systemic antibiotics to reach the infected areas, prevent the healing process (patients with diabetic feet and pressure ulcers, [30]). In such cases, antibiotic treatment, surgical debridement and drainage fail to stop the progressive tissue destruction [31][32][33][34].…”

Section: Maggots Therapy: Small Antimicrobial Peptides Peptides: the mentioning

confidence: 99%

Neuropeptide-Derived Antimicrobial Peptides from Invertebrates for Biomedical Applications

Salzet

2005

CMC

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Abstract:Since the beginning of the 20th century, important medicinal progress has led medical doctors to think that the end of devastating epidemics has arrived. In 1930, the discovery of sulfamides and penicillin opened a wide area of applications able to fight against bacterial infections. However, almost all antibiotics were baffled by the great ability to adaptation of bacteria (1) and the emergence of new bacterial agents, discovered with up-dated technologies. The living world is perpetually in co-evolution and since more than 3 billion years, bacteria have developed resistance mechanisms to overcome external aggressions. Thus, in the middle of the 80th century, multi-resistant bacteria appeared and disseminated out from hospitals. In this context, researches have been developed in order to find new antimicrobial substances to destroy such new types of bacteria. Thus, several groups have turned their focus on invertebrates, which co-evoluad with human and have appeared on the planet since a long time. Evidence of new families of antimicrobial substances isolated from invertebrates different to the classical cationic peptide family i.e. dipeptides and anionic peptides been given. Moreover, these molecules are also present in human and may serve in the innate immune response as an important survival strategy.

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Maggot therapy for the treatment of diabetic foot ulcers.

Cited by 79 publications

References 0 publications

Treatment of pressure ulcers with larvae of Lucilia sericata

Treatment of pressure ulcers with larvae of Lucilia sericata

Maggot Debridement Therapy for Peripheral Arterial Disease

Neuropeptide-Derived Antimicrobial Peptides from Invertebrates for Biomedical Applications

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