Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification

Jan, Yuh Nung

doi:10.1016/0896-6273(95)90235-x

Cited by 115 publications

(2 citation statements)

References 27 publications

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“…In these cases, the cells are initially distinct from each other either because they asymmetrically express regulators of the Notch pathway or because the ligand and receptor are differentially distributed in adjacent cells (review by Bray 2006). For instance, asymmetric segregation of Numb, which down-regulates Notch signaling through polarized receptor-mediated endocytosis, in the progeny of sensory organ precursors (SOPs) makes the Numb-positive cell Notch sending (Jan and Jan 1995). In contrast, during wing vein specification in Drosophila , expression of Delta in the vein regions induces Notch signaling in the intervein cells to inhibit vein fate, and patterning is established through a positive feedback loop (Huppert et al 1997).…”

Section: Juxtacrine Signaling: Notch As An Examplementioning

confidence: 99%

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

Perrimon¹,

Pitsouli²,

Shilo³

2012

Cold Spring Harbor Perspectives in Biology

340

267

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SUMMARY During development, signaling pathways specify cell fates by activating transcriptional programs in response to extracellular signals. Extensive studies in the past 30 years have revealed that surprisingly few pathways exist to regulate developmental programs and that dysregulation of these can lead to human diseases, including cancer. Although these pathways use distinct signaling components and signaling strategies, a number of common themes have emerged regarding their organization and regulation in time and space. Examples from Drosophila, such as Notch, Hedgehog, Wingless/WNT, BMP (bone morphogenetic proteins), EGF (epidermal growth factor), and FGF (fibroblast growth factor) signaling, illustrate their abilities to act either at a short range or over a long distance, and in some instances to generate morphogen gradients that pattern fields of cells in a concentration-dependent manner. They also show how feedback loops and transcriptional cascades are part of the logic of developmental regulation.

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Section: Juxtacrine Signaling: Notch As An Examplementioning

confidence: 99%

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

Perrimon¹,

Pitsouli²,

Shilo³

2012

Cold Spring Harbor Perspectives in Biology

340

267

View full text Add to dashboard Cite

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“…The mechanism that activates Notch signaling in one of the mitotic progeny is unclear. It could be attributable to a molecular asymmetry in which there is an unequal distribution of a component that suppresses Notch signaling (Jan and Jan, 1995;Bhat, 2014;Dong et al, 2012). Alternatively, direct Notch/Delta signaling between the two daughter cells is a potential mechanism.…”

Section: Discussionmentioning

confidence: 99%

Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos

2017

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We have examined regulation of neurogenesis by Delta/Notch signaling in sea urchin embryos. At gastrulation, neural progenitors enter S phase coincident with expression of Sp-SoxC. We used a BAC containing knocked into the locus to label neural progenitors. Live imaging and immunolocalizations indicate that Sp-SoxC-expressing cells divide to produce pairs of adjacent cells expressing GFP. Over an interval of about 6 h, one cell fragments, undergoes apoptosis and expresses high levels of activated Caspase3. A Notch reporter indicates that Notch signaling is activated in cells adjacent to cells expressing Sp-SoxC. Inhibition of γ-secretase, injection of Sp-Delta morpholinos or CRISPR/Cas9-induced mutation of results in supernumerary neural progenitors and neurons. Interfering with Notch signaling increases neural progenitor recruitment and pairs of neural progenitors. Thus, Notch signaling restricts the number of neural progenitors recruited and regulates the fate of progeny of the asymmetric division. We propose a model in which localized signaling converts ectodermal and ciliary band cells to neural progenitors that divide asymmetrically to produce a neural precursor and an apoptotic cell.

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Functional morphology of insect mechanoreceptors

Keil

1997

Microsc. Res. Tech.

386

304

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This paper reviews the structure and function of insect mechanoreceptors with respect to their cellular, subcellular, and cuticular organization. Four types are described and their function is discussed: 1, the bristles; 2, the trichobothria; 3, the campaniform sensilla; and 4, the scolopidia. Usually, bristles respond to touch, trichobothria to air currents and sound, campaniform sensilla to deformation of the cuticle, and scolopidia to stretch. Mechanoreceptors are composed of four cells: a bipolar sensory neuron, which is enveloped by the thecogen, the trichogen, and the tormogen cells. Apically, the neuron gives off a ciliary dendrite which is attached to the stimulustransmitting cuticular structures. In types 1-3, the tip of the dendrite contains a highly organized cytoskeletal complex of microtubules, the ''tubular body,'' which is connected to the dendritic membrane via short rods, the ''membrane-integrated cones'' (MICs). The dendritic membrane is attached to the cuticle via fine attachment fibers. The hair-type sensilla (types 1, 2) are constructed as first-order levers, which transmit deflection of the hair directly to the dendrite tip. In campaniform sensilla (type 3), there is a cuticular dome instead of a hair and the dendrite is stimulated by deformation of the cuticle. In these three types, a slight lateral compression of the dendrite tip is most probably the effective stimulus. In scolopidia, the dendritic membrane is most probably stimulated by stretch. On the subcellular level, connectors between the cytoskeleton, the dendritic membrane, and extracellular (cuticular) structures are present in all four types and are thought to be engaged in membrane depolarization.

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Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification

Cited by 115 publications

References 27 publications

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos

Functional morphology of insect mechanoreceptors

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