MAGED1 Is a Negative Regulator of Bone Remodeling in Mice

Liu, Mei; Xu, Lijuan; Ma, Xiao; Xu, Jiake; Wang, Jing; Xian, Mengmeng; Zhou, Xiaotian; Wang, Min; Wang, Fang; Qin, An; Pan, Qiuhui; Cheng, Wen

doi:10.1016/j.ajpath.2015.06.017

Cited by 17 publications

(18 citation statements)

References 42 publications

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“…However, few studies focused on the mechanisms mediated by Mage‐D1. Liu Mei et al . indicated that Mage‐D1‐deficient osteoclasts exhibited a higher expression of canonical NF‐kappaB and resulted in increased osteoclastogenesis but not osteoblastogenesis.…”

Section: Discussionmentioning

confidence: 88%

“…employed the microarray profiles of 96 Hybrid Mouse Diversity Panel (HMDP)‐inbred strains to determine the key genes expressed in osteoblasts. Results suggested that Mage‐D1 played a key role in osteogenesis‐associated network of genes involved in bone mineral density (BMD), and Mage‐D1‐/‐ mice showed lower BMD and osteogenic index . However, these findings focused on postnatal models of animals and differentiated osteogenic cell lines.…”

Section: Introductionmentioning

confidence: 95%

“…Mage-D1 levels fluctuated in conditional culture medium. 25,26,51 In this study, we cultured E12.5d and E19.5d EMSCs and induced E19.5d EMSCs for differential mineralization. Interestingly, no significant fluctuation (Fig.…”

Section: Mage-d1 and Ngf Play Important Roles Of Mineralized Differmentioning

confidence: 99%

“…Results suggested that Mage-D1 played a key role in osteogenesis-associated network of genes involved in bone mineral density (BMD), and Mage-D1-/-mice showed lower BMD and osteogenic index. 25,26 However, these findings focused on postnatal models of animals and differentiated osteogenic cell lines. The progenitor cells such as EMSCs were rarely investigated.…”

Section: Introductionmentioning

confidence: 99%

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p75 neurotrophin receptor regulates differential mineralization of rat ectomesenchymal stem cells

Yang

Wang

et al. 2016

Cell Proliferation

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 95%

Section: Mage-d1 and Ngf Play Important Roles Of Mineralized Differmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

p75 neurotrophin receptor regulates differential mineralization of rat ectomesenchymal stem cells

Yang

Wang

et al. 2016

Cell Proliferation

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show abstract

“…After osteoclasts were formed, cells were lysed, and total RNA was extracted using Trizol (Life Technologies, Mulgrave, Australia) in accordance with the manufacturer's protocol. The primer sets for calcitonin receptor ( CTR ), cathepsin K ( CtsK ), TRAP , and β‐actin were used as previously described by Liu et al (). The level of mRNA expression was normalized to that of β ‐ actin .…”

Section: Methodsmentioning

confidence: 99%

Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast‐like synoviocytes, and collagen‐induced arthritis rats

Liu

Zhou

et al. 2018

Journal Cellular Physiology

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The discovery of new therapeutic drugs with the ability of preventing inflammation and joint destruction with less adverse effects is urgently needed for rheumatoid arthritis (RA). Carnosic acid (CA), a major phenolic compound isolated from the leaves of Rosemary (Rosmarinus officinalis L.), has been reported to have antioxidative and antimicrobial properties. However, its effects on RA have not been elucidated. Here, we investigated the effects of CA on osteoclasts and fibroblast-like synoviocytes in vitro and on collagen-induced arthritis (CIA) in Wistar rats in vivo. Our in vitro and in vivo studies showed that CA suppressed the expression of pro-inflammatory cytokines including TNFɑ, IL-1β, IL-6, IL-8, IL-17 and MMP-3, and downregulated the production of RANKL. More importantly, we observed that CA inhibited osteoclastogenesis and bone resorption in vitro and exerted therapeutic protection against joint destruction in vivo. Further biochemical analysis demonstrated that CA suppressed RANKL-induced activations of NF-κB and MAPKs (JNK and p38) leading to the downregulation of NFATc1. Taken together, our findings provide the convincing evidence that rosemary derived CA is a promising natural compound for the treatment of RA.

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Inhibitory effects of tubeimoside I on synoviocytes and collagen‐induced arthritis in rats

Liu

Zhou²,

et al. 2018

Journal Cellular Physiology

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Advancements in rheumatoid arthritis (RA) therapies have shown considerable progresses in the comprehension of disease. However, the development of new potential medicines with relative safety and efficacy continues and natural compounds have been considered as alternatives or complementary agents to gain immense attractions. Tubeimoside I (TBMS I), a main triterpenoid saponin isolated from Bolbostemma paniculatum, has been reported to possess antiviral and anticancer effects. However, its effect on RA remains unknown. Here, we investigated the therapeutic effect of TBMS I in collagen-induced arthritis (CIA) rats and explored its underlying mechanism. Our results showed that TBMS I treatment efficaciously ameliorated inflammation and joint destruction of rats with CIA. In vitro studies revealed that TBMS I suppressed the production of pro-inflammatory cytokines including IL-1β, IL-6, IL-8 and TNFα, and downregulated the expression of MMP-9. In addition, TBMS I attenuated the destructive phenotypes of FLS of CIA rats including inhibiting proliferation and reducing migration rate. Further mechanistic analysis demonstrated that TBMS I suppressed TNFα-induced activations of NF-κB and MAPKs (p38 and JNK) leading to the downregulation of pro-inflammatory cytokines, which was beneficial to the anti-proliferative and anti-migratory activities of FLS cells. Taken together, TBMS I has a great potential to be developed into a novel therapeutic agent for the treatment of RA.

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MAGED1 Is a Negative Regulator of Bone Remodeling in Mice

Cited by 17 publications

References 42 publications

p75 neurotrophin receptor regulates differential mineralization of rat ectomesenchymal stem cells

p75 neurotrophin receptor regulates differential mineralization of rat ectomesenchymal stem cells

Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast‐like synoviocytes, and collagen‐induced arthritis rats

Inhibitory effects of tubeimoside I on synoviocytes and collagen‐induced arthritis in rats

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