2016
DOI: 10.1016/j.atherosclerosis.2016.06.026
|View full text |Cite
|
Sign up to set email alerts
|

MafB and the role of macrophage apoptosis in atherosclerosis: A time to kill, a time to heal

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
3
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
(3 citation statements)
references
References 30 publications
0
3
0
Order By: Relevance
“…Macrophage apoptosis is known to have dual role in atherogenesis (27). While playing protective role at the early stages of atherosclerosis, it promotes the plaque instability in advanced lesions.…”
Section: Discussionmentioning
confidence: 99%
“…Macrophage apoptosis is known to have dual role in atherogenesis (27). While playing protective role at the early stages of atherosclerosis, it promotes the plaque instability in advanced lesions.…”
Section: Discussionmentioning
confidence: 99%
“…MafB has been shown to regulate macrophage survival, cholesterol efflux and M2 polarization phenotype in the atherosclerotic plaque. 97 , 98 RhoB is a signaling mediator of stress and has been shown to participate in vascular activation, development and response to hypoxia, but the contribution of macrophage RhoB in atherosclerosis progression is unknown. Similarly, the contribution of Slc39a1 (a zinc transporter) and Rnf4 (an E3-ubiquitin ligase) in macrophages or in the progression of atherosclerosis has not been tested.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies also demonstrated that MafB has an antiapoptotic role [ 28 30 ], and Hamada et al found that MafB participates through the expression of apoptosis inhibitor of macrophages (AIM) [ 29 ]. In advanced lesions, macrophage apoptosis promotes lesion vulnerability and necrotic core development via defective efferocytosis, resulting in plaque instability [ 31 ]. Taken together, these findings suggest that MafB significantly regulates homeostasis in atherosclerotic lesions through C1q and AIM expression, and that C1q plays an important role in plaque instability.…”
Section: Discussionmentioning
confidence: 99%