2018
DOI: 10.1016/j.bbagrm.2017.11.009
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Maf1 phenotypes and cell physiology

Abstract: As a master regulator of transcription by RNA polymerase (Pol) III, Maf1 represses the synthesis of highly abundant non-coding RNAs as anabolic signals dissipate, as the quality or quantity of nutrients decreases, and under a wide range of cellular and environmental stress conditions. Thus, Maf1 responds to changes in cell physiology to conserve metabolic energy and to help maintain appropriate levels of tRNAs and other essential non-coding RNAs. Studies in different model organisms and cell-based systems show… Show more

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Cited by 24 publications
(27 citation statements)
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References 66 publications
(119 reference statements)
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“…Studies of transcription and metabolism conducted to date on Maf1 KO mice have focused mostly on the fasted state since differences with wild-type (WT) mice were expected to be greater under conditions that cause Maf1-dependent repression. However, recent work indicates that mammalian Maf1, unlike yeast, functions as a chronic repressor (10). In proliferating IMR90htert cells under nutrient-replete conditions, knockdown of Maf1 increases the genome-wide occupancy of the polymerase at active Pol III loci and increases nascent tRNA synthesis (11).…”
Section: Significancementioning
confidence: 99%
“…Studies of transcription and metabolism conducted to date on Maf1 KO mice have focused mostly on the fasted state since differences with wild-type (WT) mice were expected to be greater under conditions that cause Maf1-dependent repression. However, recent work indicates that mammalian Maf1, unlike yeast, functions as a chronic repressor (10). In proliferating IMR90htert cells under nutrient-replete conditions, knockdown of Maf1 increases the genome-wide occupancy of the polymerase at active Pol III loci and increases nascent tRNA synthesis (11).…”
Section: Significancementioning
confidence: 99%
“…Pol III transcription is hence tightly regulated in response to stress and growth signals, and several signaling pathways converge to modulate the function of the Pol III machinery including its central negative regulator, Maf 2,6 . Maf1 is conserved across eukaryotes, and has been studied in yeast, flies, worms, plants, parasites and mammalian systems (reviewed in 7,8 ). Recently, it was demonstrated that overexpression of Maf1 in the gut of flies increases the lifespan of these animals 9 .…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have reported that perturbing Maf1 function by overexpression or knockdown affects the expression of certain genes transcribed by RNA polymerase II (reviewed in 13 ). In contrast, RNAseq analysis of WAT from fasted wild-type and Maf1 -/mice did not identify any significantly affected genes 11 .…”
Section: Analysis Of the Pol II Transcriptome In Maf1 -/Livermentioning
confidence: 99%
“…Another enriched GO term, translation, reflects the apparent down-regulation of genes encoding 10 subunits of the cytoplasmic ribosome ( Figure 4C, orange triangles, Table S6). We also searched our gene list for protein coding genes (Fasn, Acaca, TBP and PTEN) whose expression has been reported to change upon Maf1 overexpression and knockdown in C. elegans and/or in various cancer cell lines of hepatic origin 15,17,24 , reviewed in 13 . None of these genes were changed at our low stringency cutoff (Table S6).…”
Section: Analysis Of the Pol II Transcriptome In Maf1 -/Livermentioning
confidence: 99%
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