Maedi Visna virus infection and
            <i>TMEM154</i>
            genotypes in Valle del Belìce sheep breed

Riggio, Silvia; Gerlando, Rosalia Di; Mastrangelo, Salvatore; Rizzuto, Ilaria; Tolone, Marco; Sardina, Maria Teresa

doi:10.1080/1828051x.2023.2243095

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…Based on the evidence that MVV can be transmitted via infected ram semen (Preziuso et al,2003;Kalogianni et al,2020), careful selection of breeding rams from infection-free herds is paramount to prevent transmission. Recent studies have shed light on resistant and susceptible genes associated with small ruminant lentiviruses, suggesting the possibility of the presence of some genes that may be resistant to this disease (Yaman et al, 2019;Riggio et al,2023;Heaton et al,2013;White and Knowles,2013). By leveraging the findings of these studies that highlighted the potential for genetic resistance against the disease, it may be feasible to to breed genetically resistant breeds, offering enhanced protection against MVV infection.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Maedi-Visna Infection in Sheep in the Central Black Sea Region of Türkiye

Kuruçay,

Müftüoğlu,

Gözel

et al. 2024

MJAVL

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Maedi-Visna is a slowly progressive infection of sheep that affects the respiratory and nervous systems and causes significant yield losses worldwide. This study was conducted to assess the seroprevalence of Maedi-Visna infection in sheep across several provinces in the Central Black Sea region of Türkiye, namely Samsun, Sinop, Ordu, Giresun, Amasya and Tokat. A total of 476 sheep serum samples were collected for further analysis. The presence of antibodies in the sera was determined by Ab ELISA. As a result of the study, 263 (55.25%) blood serum samples were positive for the presence of MVV antibodies. Seropositivity rates by province were as follows: Samsun 45%, Sinop 80%, Ordu 58.75%, Giresun 35%, Amasya 38.75%, Tokat 75%. Notably, our findings suggest a significantly high seroprevalence of Maedi-Visna infection in this region compared to other studies conducted in different parts of Türkiye This information is pivotal for understanding the extent of the infection in the sheep population of the Central Black Sea region and can contribute to the development of strategies for disease management and control.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Maedi-Visna Infection in Sheep in the Central Black Sea Region of Türkiye

Kuruçay,

Müftüoğlu,

Gözel

et al. 2024

MJAVL

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“…All the individuals were genotyped at the TMEM154 gene by direct Sanger sequencing, to estimate the genotype frequencies of the E35K polymorphism ( Riggio et al, 2023 ).…”

Section: Methodsmentioning

confidence: 99%

“…In particular, the genetic tools have been used to describe several candidate genes associated with SRLV seroreaction (Abendaño et al, 2021). The TMEM154 has been reported to be the major gene associated to VMV susceptibility by Heaton et al (2012) and several subsequent independent studies (Molaee et al, 2018;Molaee et al, 2019;Yaman et al, 2019;Ramírez et al, 2021;Tumino et al, 2022;Riggio et al, 2023;Rodrigues et al, 2023). The polymorphism involved in resistance/susceptibility is located in the portion of the gene encoding the extracellular part of the protein and is characterised by the substitution, at position 35 of the protein, of glutamate (E) amino acid with lysine (K) one (Heaton et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

A high-density genome-wide approach reveals novel genetic markers linked to small ruminant lentivirus susceptibility in sheep

Riggio,

Tolone,

Sottile

et al. 2024

Front. Genet.

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Visna/Maedi virus (VMV) is lentiviral disease of sheep responsible for severe production losses. Multiple genomic regions associated with infection were reported indicating genetic complexity. In this study, a combined genome-wide approach using a high-density SNP array has been performed, comparing VMV-infected (n = 78) and non-infected (n = 66) individuals of the Valle del Belice breed. The serological tests showed a seroprevalence of 26%. The comparison among results from different approaches (GWAS, Fisher’s exact test and the FST analysis) revealed two association signals: on OAR03 close to the GRIN2B gene and on OAR05 close to the TMEM232 gene. To the best of our knowledge, there has been no previous association between these genes and lentiviral infection in any species. The GRIN2B gene plays a role in pain response, synaptic transmission, and receptor clustering, while TMEM232 is involved in the development of immune-related disorders. The results highlighted new aspects of the genetic complexity related to the resistance/susceptibility to VMV in sheep, confirming that studies on different breeds can lead to different results. The ideal approach for validation of the markers identified in our study is to use samples from a population independent from the discovery population with the same phenotype used in the discovery stage.

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Maedi Visna virus infection and TMEM154 genotypes in Valle del Belìce sheep breed

Cited by 2 publications

References 30 publications

Seroprevalence of Maedi-Visna Infection in Sheep in the Central Black Sea Region of Türkiye

Seroprevalence of Maedi-Visna Infection in Sheep in the Central Black Sea Region of Türkiye

A high-density genome-wide approach reveals novel genetic markers linked to small ruminant lentivirus susceptibility in sheep

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