Madelung's Disease

Yeh, Nai-Cheng; Yang, Chwen-Yi; Chou, Chien-Wen; Yen, Feng-Chieh; Lee, Shang-Yu; Tien, Kai‐Jen

doi:10.1210/jc.2012-1649

Cited by 8 publications

(13 citation statements)

References 4 publications

(2 reference statements)

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“…The diagnosis of MSL is primarily based on physical examination, clinical history, and imaging studies [5]. With this case report, the authors intend to demonstrate that although many authors advocate a phenotypic exclusive subtype 2 of the disease, for women, this is not always the case.…”

Section: Resultsmentioning

confidence: 91%

“…Its pathogenesis is still unknown and may be associated with neuropathy, hyperuricemia, liver disease and malignant tumors of the airways and digestive tract [4]. Two types of Madelung's disease have been described [5]. In type 1, most common in men, fat accumulates around the neck, submental region, and upper back, known as "Madelung collar" [4].…”

Section: Introductionmentioning

confidence: 99%

“…Fatty deposits rarely extend to the mediastinum and larynx in type 2 [6]. Most patients have a history of chronic alcoholism [5].…”

Section: Introductionmentioning

confidence: 99%

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Pseudoathletic Appearance: A Case Report in a Male

Moreira¹,

Pereira²,

Santos³

et al. 2015

CRCM

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Multiple Symmetric Lipomatosis (MSL) is a rare condition characterized by a symmetrical pattern of massive fatty deposits. This condition predominates in males, between 30 and 60 years. In this article, the authors present a case report of a 47-year-old man that resorted to consultation to perform routine medical exams, without any complaint associated. Physical examination shows multiple bilateral swellings in the proximal region of the upper limbs and analytically presents hyperuricemia, hypertriglyceridemia, hypercholesterolemia and changes in hepatic tests. CT revealed the presence of non-encapsulated homogeneous masses of adipose tissue in the proximal region of the limbs. Currently the patient is asymptomatic, being monitoring in consultation.

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Section: Resultsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Pseudoathletic Appearance: A Case Report in a Male

Moreira¹,

Pereira²,

Santos³

et al. 2015

CRCM

View full text Add to dashboard Cite

show abstract

“…One study reported that, out of nine patients, only two had an association with alcohol abuse (6). On the other hand, it has been suggested that Madelung's disease might be caused by a local defect in catecholamine-induced lipolysis (7). Several other studies asserted that deletions in the mtDNA have been detected in some patients, although a defect in the mitochondrial respiratory chain could be an elusive biochemical defect (8,9).…”

Section: Discussionmentioning

confidence: 99%

Imaging Features of Madelung's Disease: Case Report

Kang

Lee

Cha

et al. 2015

Investig Magn Reson Imaging

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“…Typically, Madelung's disease affects white, middle-aged men of Mediterranean origin who have a history of alcohol overuse. Diabetes mellitus, lipid disorders, hypothyroidism and liver disease are common comorbidities [46,47]. Dercum's disease (adiposis dolorosa) is a condition characterized by painful, easily bruised fatty tumours, which usually occurs in obese, post-menopausal women and is associated with type 2 diabetes, asthenia, weakness and mental phenomena such as depression, anxiety, confusion and dementia.…”

Section: Differential Diagnosismentioning

confidence: 99%

Lipedema: a clinical entity

Łyszczak¹,

Szuba²

2018

Acta Angiologica

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Lipedema is a chronic, progressive disorder of adipose tissue, found almost exclusively in women, that involves disproportionate subcutaneous fat depositions, leading to progressive and symmetric enlargement of the legs. The condition usually appears at puberty or in the third decade of life. Many patients report a family history of such disorder. The diagnosis is usually based on the physical examination and medical history. If left untreated, lipedema may result in secondary lymphatic dysfunction, physical impairment and mental problems, leading to significant damage to patient's quality of life. The condition is frequently misdiagnosed as lymphedema or mistreated as obesity. Other than that, the differential diagnosis includes chronic venous insufficiency, constitutional variability of the legs, lipohypertrophy, Dercum's disease, Madelung's disease. The treatment options include diet and compression therapy, conservative treatment of secondary edema and surgical interventions. There is an urgent need for further studies on the pathogenesis of lipedema, epidemiology, diagnostic criteria and possible curative treatment.

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Madelung's Disease

Cited by 8 publications

References 4 publications

Pseudoathletic Appearance: A Case Report in a Male

Pseudoathletic Appearance: A Case Report in a Male

Imaging Features of Madelung's Disease: Case Report

Lipedema: a clinical entity

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