Madelung’s Disease: Comorbidities, Fatty Mass Distribution, and Response to Treatment of 22 Patients

Benign symmetrical lipomatosis (Madelung's disease) is a rare condition of unclear aetiology characterized by numerous, unencapsulated lipomatous deposits. The only effective treatment is by surgical intervention; however, there is no consensus in the optimal approach. We present the case of a patient who required staged, multi-modality treatment to achieve disease quiescence. The case highlights the usefulness of magnetic resonance imaging as a tool for assessment as well as preoperative planning.

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“…Brea‐García et al . supports the notion that lower recurrence rates will occur when lipectomy and liposuction are used together .…”

Section: Resultssupporting

confidence: 66%

A surgical view on the treatment of Madelung's disease

et al. 2015

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“…Recurrence over a period of months to years in the initial location as well as elsewhere is common. [26,27]. The relevant features of MSL are summarized in Table 3.…”

Section: Discussionmentioning

confidence: 99%

Syndromic Lipomatosis of the Head and Neck: A Review of the Literature

et al. 2015

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This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

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“…In particular, surgery is important for the symptomatic relief of patients with respiratory problems, including dyspnea and dysphagia. Because the fatty deposits of Madelung's disease are unencapsulated, and diffusely infiltrate muscles and vessels without a clear plane for dissection, complete excision is very difficult and recurrence rates are high (3).…”

Section: Discussionmentioning

confidence: 99%