Mad honey intoxication: A systematic review on the 1199 cases

Silici, Sibel; Atayoğlu, Ali Timuçin

doi:10.1016/j.fct.2015.10.018

Cited by 43 publications

(52 citation statements)

References 57 publications

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“…Grayanotoxins are known to affect voltage-dependent Na + channel gating. Possibly due to this kind of action, and despite its toxicity, mad honey is used as folk medicine for hypertension, sexual dysfunction, and other ailments (Koca and Koca, 2007; Silici and Atayoglu, 2015). …”

Section: Honeymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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Section: Honeymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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“…Fatalities are rare and patients are discharged from hospital usually within 1 or 2 days. Treatment involves mainly atropine and saline i.v …”

Section: Drugs With the Major Effects On The Heartmentioning

confidence: 99%

“…Treatment involves mainly atropine and saline i.v. [226][227][228] As mentioned, class I antidysrhythmic drugs block Na + -channels. However, many of these drugs also possess additional activities producing a variety of cardiovascular actions/toxicities.…”

Section: Sodium Channelsmentioning

confidence: 99%

Comprehensive review of cardiovascular toxicity of drugs and related agents

Mladěnka

Applová

Patočka

et al. 2018

Medicinal Research Reviews

203

120

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Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta‐blockers, calcium channel blockers, female hormones, nonsteroidal anti‐inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.

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“…Chesnut plant is one of the best sources of nectar and pollen for honeybees. Chestnut honey with dark color and bitter taste, can stay in a liquid state for a long time because of its slow crystallization rate [1,2].…”

Section: Introductionmentioning

confidence: 99%

Some Characteristic Properties of Chestnut and Rhododendron Honeys in Turkey

Mayda

Özkök

Sorkun

2018

HJBC

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T ürkiye'de genellikle Karadeniz bölgesinde üretilen kestane (Castanea sativa Mill.) ve ormangülü (Rhododendron spp. L.) (delibal) balları içerdiği organik bileşenler ve yüksek antioksidan seviyeleri ile bilinen önemli ballardır.Bu çalışmanın ilk aşamasında kestane ve ormangülü ballarının melissopalinolojik farklılıkları araştırılmış, ikinci aşamasında ise ormangülü, kestane ve kestane ormangülü karışık balların şeker içerikleri ve kimyasal bileşenleri belirlenmiştir. Bu amaçla Türkiye'nin Karadeniz Bölgesinde, 4 farklı yerden toplamda 18 bal örneği toplanmıştır ve mikroskop ile melissopalinolojik analizleri yapılmıştır. Kimyasal bileşim ve şeker içeriği (fruktoz&glikoz) HPLC ve GC-MS ile belirlenmiştir. Melissopalinolojik analizler sonrasında 10 balın monofloral kestane balı, 2'sinin monofloral ormangülü ve 6'sının da kestane ormangülü karışık ballar olduğu saptanmıştır. HPLC ile yapılan şeker analizleri sonucunda F/G oranının 1.17 ve 1.80 arasında olduğu, GC-MS kimyasal analizleri sonucunda da balların alkoller, aldehidler, ketonlar, alifatik asit ve esterleri, carboksilik asit ve esterleri ile flavanoidleri içerdiği ortaya çıkarılmıştır.

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Mad honey intoxication: A systematic review on the 1199 cases

Cited by 43 publications

References 57 publications

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Comprehensive review of cardiovascular toxicity of drugs and related agents

Some Characteristic Properties of Chestnut and Rhododendron Honeys in Turkey

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