Maculopathy in Cynomolgus Monkeys

Feeney-Burns, L; Malinow, M. R.; Klein, Michael L.; Neuringer, Martha

doi:10.1001/archopht.1981.03930010664013

Cited by 30 publications

(6 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Feeney-Burns et al (1981) found that these degenerating RPE cells generally corresponded to punctate fluorescein angiographic window defects, while patches of RPE cells with high lipofuscin and low melanin content corresponded to areas of more diffuse hyperfluorescence.…”

Section: Non-human Primate Models Of Dry Amdmentioning

confidence: 92%

“…In some cases, ophthalmoscopic spots appearing as drusen were found to correspond not with sub-RPE deposits but with RPE cells filled with vacuoles and lipid droplets, a pattern termed lipoidal degeneration (Anderson et al, 2006; Feeney-Burns et al, 1981; Fine and Kwapien, 1978; Umeda et al, 2005b). Feeney-Burns et al (1981) found that these degenerating RPE cells generally corresponded to punctate fluorescein angiographic window defects, while patches of RPE cells with high lipofuscin and low melanin content corresponded to areas of more diffuse hyperfluorescence.…”

Section: Non-human Primate Models Of Dry Amdmentioning

confidence: 99%

See 1 more Smart Citation

Animal models of age related macular degeneration

Pennesi

Neuringer

Courtney

2012

Molecular Aspects of Medicine

320

292

View full text Add to dashboard Cite

Age related macular degeneration (AMD) is the leading cause of vision loss of those over the age of 65 in the industrialized world. The prevalence and need to develop effective treatments for AMD has lead to the development of multiple animal models. AMD is a complex and heterogeneous disease that involves the interaction of both genetic and environmental factors with the unique anatomy of the human macula. Models in mice, rats, rabbits, pigs and non-human primates have recreated many of the histological features of AMD and provided much insight into the underlying pathological mechanisms of this disease. In spite of the large number of models developed, no one model yet recapitulates all of the features of human AMD. However, these models have helped reveal the roles of chronic oxidative damage, inflammation and immune dysregulation, and lipid metabolism in the development of AMD. Models for induced choroidal neovascularization have served as the backbone for testing new therapies. This article will review the diversity of animal models that exist for AMD as well as their strengths and limitations.

show abstract

Section: Non-human Primate Models Of Dry Amdmentioning

confidence: 92%

Section: Non-human Primate Models Of Dry Amdmentioning

confidence: 99%

Animal models of age related macular degeneration

Pennesi

Neuringer

Courtney

2012

Molecular Aspects of Medicine

320

292

View full text Add to dashboard Cite

show abstract

“…Lesions of the fundus have been reported in a study providing a representative overview of more than 2000 monkeys having a 7.9% incidence of ocular lesions and 6.6% incidence of fundus lesions 11 . Only a few cases of spontaneous macular degeneration, called drusenoid maculopathy, have been described in rhesus monkeys 68 and cynomolgus monkeys 69 , 70 . On the other hand, there are a few colonies of monkeys with familial macular degeneration resembling human AMD 71 , 72 , 73 .…”

Section: Spontaneous and Toxic Ocular Lesions In Laboratory Animalsmentioning

confidence: 99%

Characteristics of structures and lesions of the eye in laboratory animals used in toxicity studies

et al. 2015

View full text Add to dashboard Cite

Histopathology of the eye is an essential part of ocular toxicity evaluation. There are structural variations of the eye among several laboratory animals commonly used in toxicity studies, and many cases of ocular lesions in these animals are related to anatomical and physiological characteristics of the eye. Since albino rats have no melanin in the eye, findings of the fundus can be observed clearly by ophthalmoscopy. Retinal atrophy is observed as a hyper-reflective lesion in the fundus and is usually observed as degeneration of the retina in histopathology. Albino rats are sensitive to light, and light-induced retinal degeneration is commonly observed because there is no melanin in the eye. Therefore, it is important to differentiate the causes of retinal degeneration because the lesion occurs spontaneously and is induced by several drugs or by lighting. In dogs, the tapetum lucidum, a multilayered reflective tissue of the choroid, is one of unique structures of the eye. Since tapetal cells contain reflecting crystals in which a high level of zinc has been demonstrated chemically, drug-induced tapetum degeneration is possibly related to zinc chelation. The eye of the monkey has a macula similar to that of humans. The macula consists only of cones with a high density, and light falls directly on the macula that plays an important role in visual acuity. Macular degeneration occurring in monkeys resembles histopathologically that of humans. Hence, the eye of the monkey is a suitable model to investigate macular degeneration and to assess drug-induced macular lesions.

show abstract

“…In the eye, various insults evoke engorgement of RPE cells with large oil red O-binding intracellular droplets (El Baba et al, 1986; Feeney-Burns et al, 1981; Fine and Kwapien, 1978; Majji et al, 2000). Such cells could conceivably contribute to BrM neutral lipid if they die and release their droplets.…”

Section: Evidence For An Intra-ocular Apob-containing Lipoproteinmentioning

confidence: 99%

Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins

Curcio

Johnson

Huang

et al. 2009

Progress in Retinal and Eye Research

232

208

View full text Add to dashboard Cite

The largest risk factor for age-related macular degeneration (ARMD) is advanced age. A prominent age-related change in the human retina is the accumulation of histochemically detectable neutral lipid in normal Bruch’s membrane (BrM) throughout adulthood. This change has the potential to have a major impact on physiology of the retinal pigment epithelium (RPE). It occurs in the same compartment as drusen and basal linear deposit, the pathognomonic extracellular, lipid-containing lesions of ARMD. Here we present evidence from light microscopic histochemistry, ultrastructure, lipid profiling of tissues and isolated lipoproteins, and gene expression analysis that this deposition can be accounted for by esterified cholesterol-rich, apolipoprotein B-containing lipoprotein particles constitutively produced by the RPE. This work collectively allows ARMD lesion formation and its aftermath to be conceptualized as a response to the retention of a sub-endothelial apolipoprotein B lipoprotein, similar to a widely accepted model of atherosclerotic coronary artery disease (CAD) (Tabas et al., 2007). This approach provides a wide knowledge base and sophisticated clinical armamentarium that can be readily exploited for the development of new model systems and the future benefit of ARMD patients.

show abstract

Maculopathy in Cynomolgus Monkeys

Cited by 30 publications

References 6 publications

Animal models of age related macular degeneration

Animal models of age related macular degeneration

Characteristics of structures and lesions of the eye in laboratory animals used in toxicity studies

Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins

Contact Info

Product

Resources

About