Maculopapular rash to S‐carboxymethylcysteine‐lysine (carbocisteine)

Carbocisteine‐induced Stevens–Johnson syndrome confirmed by inadvertent re‐exposure

“…However, it may rarely induce cutaneous adverse reactions such as maculopapular rash and fixed drug eruption (FDE). 4,5 To our knowledge, this is the first case report of SJS after carbocisteine ingestion confirmed by oral re-administration. Recently, in a disproportionality analysis on drug-induced SJS from the World Health Organization pharmacovigilance database, carbocisteine had a strong signal as a causative drug, in spite of no relevant cases reported on PubMed to date.…”