Macular versus Retinal Nerve Fiber Layer Parameters for Diagnosing Manifest Glaucoma

Oddone, Francesco; Lucenteforte, Ersilia; Michelessi, Manuele; Rizzo, Stanislao; Donati, Simone; Parravano, Mariacristina; Virgili, Gianni

doi:10.1016/j.ophtha.2015.12.041

Cited by 116 publications

(88 citation statements)

References 71 publications

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“…GCC thickness, complementary to pRNFL thickness, also showed good glaucoma-diagnostic ability 7. A recent meta-analysis by Oddone et al revealed that the glaucoma-diagnostic ability of the macular parameters is comparable to that of the RNFL ones for diagnosis of manifest glaucoma 29. Their results for GCIPL thickness showed that the best parameters were inferior RNFL thickness and minimum GCIPL thickness, with sensitivities of 0.80 (95% CI 0.68 to 0.89) and 0.78 (95% CI 0.66 to 0.86), respectively, and for GCC thickness, the best parameters were global loss volume (for RTVue OCT) and the inferior sector (for Topcon 3D-OCT) with sensitivities of 0.64 (95% CI 0.46 to 0.79) and 0.67 (95% CI 0.57 to 0.76), respectively.…”

Section: Introductionmentioning

confidence: 99%

Macular imaging by optical coherence tomography in the diagnosis and management of glaucoma

Kim

Park

2017

Br J Ophthalmol

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The macular area is important to the detection of glaucomatous retinal ganglion cell (RGC) damage. Macular thickness complementary to peripapillary retinal nerve fibre layer (RNFL) thickness can well reflect glaucomatous damage, given that the macula contains more than 50% of the RGCs in a multilayered pattern and larger RGC bodies compared with their axons. Thus, macular ganglion cell thickness parameters recently have been considered to be an effective glaucoma-diagnostic tool comparable to RNFL thickness parameters. Furthermore, spectral-domain optical coherence tomography ganglion cell-inner plexiform layer thickness and deviation maps can provide additional information essential for distinguishing glaucomatous changes from other, myopia-associated or macular disease-associated changes. Therefore, our aim with this study was to review the clinical application of macular imaging by optical coherence tomography and to provide essential clinical tips for its use in the diagnosis and management of glaucoma.

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Section: Introductionmentioning

confidence: 99%

Macular imaging by optical coherence tomography in the diagnosis and management of glaucoma

Kim

Park

2017

Br J Ophthalmol

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“…38-40 Evidence to date suggests that it provides better diagnostic performance than OCT assessment of the macula in glaucoma, 5,6 though it will sometimes miss highly localized damage that can be detected by macular OCT analysis. 41 Average peripapillary RNFLT is highly repeatable; in a study using the Cirrus OCT (Carl-Zeiss Meditec Inc.) it was reported to have a 1.9% intra-visit coefficient of variation.…”

Section: Discussionmentioning

confidence: 99%

“…1 Glaucomatous eyes have been shown to have reduced retinal nerve fiber layer thickness (RNFLT), 2,3 optic nerve head minimum rim width (MRW), 4 and macular inner retinal layer thickness, 5,6 among other structural abnormalities that can be quantified using OCT. Furthermore, reductions in these measures correlate with reduced function, 2,7,8 and imaging tests are preferred over perimetry by patients.…”

Section: Introductionmentioning

confidence: 99%

Localized Changes in Retinal Nerve Fiber Layer Thickness as a Predictor of Localized Functional Change in Glaucoma

Gardiner

Fortune

Demirel

2016

American Journal of Ophthalmology

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Purpose To determine how well rates of localized retinal nerve fiber layer thickness (RNFLT) change correlate with rates of sensitivity change at corresponding locations in the visual field in glaucoma. Design Retrospective Cohort Study Methods 364 eyes of 191 participants, with suspected or confirmed glaucoma as judged by experienced clinicians, were tested every six months with perimetry and optical coherence tomography (OCT). For each 24-2 visual field location, the corresponding sectoral peripapillary RNFLT was defined using a 30° sector, centered on the angle of nerve fiber entry into the optic nerve head. Rates of change of pointwise sensitivity and sectoral RNFLT were calculated over the last 8 visits at which reliable data were obtained. Passing-Bablok regression was used to predict the rate of pointwise sensitivity change from the rate of sectoral RNFLT change, for each location. Results Rates of sectoral RNFLT change were significantly predictive of rates of pointwise sensitivity change at all locations in the field. Correlations were modest, averaging 0.15, ranging from 0.03 to 0.25 depending on the location. A 1μm/y more rapid thinning in corresponding sectors was associated with 0.3dB/y more rapid loss in the superior visual field, but less than 0.1dB more rapid loss at many locations in the inferior visual field. Conclusions Localized RNFL thinning is associated with sensitivity loss at corresponding locations in the visual field, and their rates of change are significantly correlated. Peripapillary RNFLT may be used to monitor localized changes caused by glaucoma that have measurable consequences for a patient's vision.

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“…5,6 Banister et al 5 (see page 930) conducted a diagnostic accuracy study of 3 imaging technologies in a large cohort of patients referred with a possible diagnosis of glaucoma. Oddone et al 6 (see page 939) carried out a systematic review and meta-analysis of studies that compared the diagnostic accuracy of retinal nerve ﬁber parameters and macular parameters using the same imaging technology, spectral-domain optical coherence tomography (SD OCT).…”

mentioning

confidence: 99%

“…In the other study in this issue, Oddone et al 6 present a systematic review and meta- analysis of 32 diagnostic studies comparing macular parameters with RNFL parameters for diagnosing glaucoma. This study used OCT data from a related systematic review that the same group has published in The Cochrane Library .…”

mentioning

confidence: 99%

Imaging the Posterior Pole in Glaucoma: Necessary But Not Sufficient

Jampel

2016

Ophthalmology

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Macular versus Retinal Nerve Fiber Layer Parameters for Diagnosing Manifest Glaucoma

Cited by 116 publications

References 71 publications

Macular imaging by optical coherence tomography in the diagnosis and management of glaucoma

Macular imaging by optical coherence tomography in the diagnosis and management of glaucoma

Localized Changes in Retinal Nerve Fiber Layer Thickness as a Predictor of Localized Functional Change in Glaucoma

Imaging the Posterior Pole in Glaucoma: Necessary But Not Sufficient

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