Macular Thickness Profiles of Intraretinal Layers in Myopia Evaluated by Ultrahigh-Resolution Optical Coherence Tomography

Liu, Xinting; Shen, Meixiao; Yuan, Yongyi; Huang, Shenghai; Zhu, Dexi; Ma, Qingkai; Ye, Xinjie; Liu, Fan

doi:10.1016/j.ajo.2015.03.012

Cited by 74 publications

(76 citation statements)

References 38 publications

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“…Our tomographic thickness data obtained from our custom-made OCT with the implementation of Orion software are in agreement with the published data 31,32,34,35. Sull et al compared TRT in ETDRS partitions obtained with several commercial devices and found the results obtained with SD-OCT to be similar 21.…”

Section: Discussionsupporting

confidence: 89%

“…These findings may possibly be because the ONL in the present study included ONL and IS, and PR might include the outer segment of photoreceptors. The thickness values of OPL layer in ETDRS sectors were lower than those in other studies,22,25,37,39 but similar to the value reported by Liu et al35 Since the OCT used in the present study and by Liu et al are both custom-built systems with similar hardware configuration, similar results from healthy subjects may be expected. The remaining differences between the present study and other previous reports may also be simply due to the variation across normal subjects, imaging resolution, and algorithm differences.…”

Section: Discussionsupporting

confidence: 89%

“…Given the lack of standardization and consensus among the devices, we may interpret our findings in the context of the existing literature. Compared with previous studies,35,37,38 the average thickness value of ONL was higher in the present study, while the thickness values of ONL and the inner segment of photoreceptors (IS) were similar to those in previous studies 37,39. Furthermore, the average thickness of PR was consistent with that of the outer segment of photoreceptors 22,38,39.…”

Section: Discussionsupporting

confidence: 77%

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The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

Tan¹,

Ye²,

Jiang³

et al. 2016

OPTH

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PurposeTo determine the repeatability and profiles with different partition methods in intraretinal thickness layers in healthy human subjects, using optical coherence tomography (OCT).MethodsA custom-built ultrahigh-resolution OCT was used to acquire three-dimensional volume of the macula in 20 healthy subjects. The dataset was acquired twice using the macular cube 512×128 protocol in an area of 6×6 mm2 centered on the fovea. Commercially available segmentation software (Orion™) was used to segment the dataset into thickness maps of six intraretinal layers. The coefficient of repeatability and intraclass coefficient of correlation (ICC) were analyzed using hemispheric zoning and sectors defined by the Early Treatment Diabetic Retinopathy Study (ETDRS).ResultsAll datasets were successfully segmented to create six thickness maps of individual intraretinal layers. Coefficients of repeatabilities of these layers in hemispheric zones ranged from 0.9 to 6.6 µm, with an average of 3.6 µm (standard deviation [SD] 1.4), which was not significantly different compared to ETDRS sectors (P>0.05). ICCs of these layers in hemispheric zones ranged from 0.68 to 0.99, with an average of 0.91 (SD 0.07). There were no significant differences in ICCs between two zoning methods (P>0.05). Significant variations of tomographic intraretinal thicknesses were found between the inner and outer annuli and among the quadrantal sectors within the inner and outer annuli (P<0.05). Significant variations of the quadrantal sectors including both inner and outer annuli were evident in intraretinal layers (P<0.05) except for the outer plexiform layer.ConclusionThe measurement repeatabilities of tomographic thicknesses of intraretinal layers are comparable using both hemispheric and ETDRS partitions in volumetric data combined with the commercially available segmentation software. In keeping with known, normal anatomical variation, significant differences in tomographic thickness in various intraretinal layers were apparent in both hemispheric and ETDRS sectors.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

Tan¹,

Ye²,

Jiang³

et al. 2016

OPTH

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“…Studies of adults have also documented reductions in total retinal thickness [32–34] and retinal layer thickness [33,34] in the parafoveal and perifoveal zones associated with myopia, typically of slightly higher magnitude than observed in our current study. The pattern of change in retinal layer thickness with myopia documented in adults appears to differ from what we have observed in children, with adult studies documenting evidence of thinning in inner (e.g.…”

Section: Discussionsupporting

confidence: 69%

Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes

2017

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Knowledge of the normal in vivo thickness of the retina, and its individual layers in pediatric populations is important for diagnosing and monitoring retinal disorders, and for understanding the eye’s normal development and the impact of eye growth and refractive error such as myopia (short-sightedness) upon retinal morphology. In this prospective, observational longitudinal study, total retinal thickness (and individual retinal layer thickness) and the changes in retinal morphology occurring over an 18-month period were examined in 101 children with a range of refractive errors. In childhood, the presence of myopia was associated with subtle but statistically significant (p<0.05) changes in the topographical thickness distribution of macular retinal thickness (and retinal layer thickness), characterised by a thinning of the parafoveal retina (and parafoveal or perifoveal thinning in most outer and inner retinal layers). The parafoveal retina was on average 6 μm thinner in myopic children. However, over 18 months, longitudinal changes in retinal thickness and individual layers were of small magnitude (average changes of less than 2 μm over 18 months), indicative of a high degree of stability in retinal morphology in healthy adolescent eyes, despite significant eye growth over this same period of time. This provides the first detailed longitudinal assessment of macula retinal layer morphology in adolescence, and delivers new normative data on expected changes in retinal structure over time and associated with myopia during this period of childhood development.

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“…2C) as already described in our previously published articles. 21,22 Manual inspection and a few corrections were still required, especially in low-quality images. In the current study, the retina was divided into retinal nerve fiber layer (RNFL), ganglion cell layer and inner plexiform layer (GCIP), inner nuclear layer (INL), outer plexiform layer (OPL), Henle fiber layer and outer nuclear layer (HFLþONL), myoid and ellipsoid zone (MEZ), outer segment of the photoreceptor cell (OS), and interdigitation zone and retinal pigment epithelium (IZþRPE).…”

Section: Sd-oct Procedures and Data Collectionmentioning

confidence: 99%

Retinal Microvascular Impairment in the Early Stages of Parkinson's Disease

Kwapong

Peng

et al. 2018

Invest. Ophthalmol. Vis. Sci.

Self Cite

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PURPOSE. To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson's disease (PD) and find a correlation between the microvascular impairment and the neuronal damage.METHODS. This is a prospective, observational study including 49 eyes from 38 PD patients in their early stages and 34 eyes from 28 healthy controls with comparable age range. Macula microvasculature was evaluated with the spectral-domain optical coherence tomography (SD-OCT) angiography and intraretinal layer thickness evaluated with the SD-OCT. A custom algorithm was used for custom segmentation of retinal thickness and quantification of the superficial and deep microvascular density of the macula, respectively.RESULTS. PD patients showed reduced microvascular density in most of the areas of the whole retina. In the superficial retinal capillary plexus, statistical difference (P < 0.01) was seen in the total annular zone (TAZ), superior, temporal, inferior, and nasal zones. In PD patients, there was a strong correlation between the average ganglion cell layer and inner plexiform (GCIP) thickness and the TAZ of the superficial microvascular density (r ¼ 0.062, P ¼ 0.032).CONCLUSION. We demonstrated that retinal microvascular density decreased in PD patients. The correlation between microvascular impairment in the superficial retinal capillary layer and GCIP thinning also revealed that the retinal microvascular abnormality may contribute to the neurodegeneration in PD patients. OCT-A with quantitative analysis offers a new path of study and will likely be useful in the future as an objective biomarker for detecting vessel impairment in early stages of PD.

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Macular Thickness Profiles of Intraretinal Layers in Myopia Evaluated by Ultrahigh-Resolution Optical Coherence Tomography

Cited by 74 publications

References 38 publications

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

The measurement repeatability using different partition methods of intraretinal tomographic thickness maps in healthy human subjects

Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes

Retinal Microvascular Impairment in the Early Stages of Parkinson's Disease

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