Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults

Lee, Samantha Sze‐Yee; Lingham, Gareth; Alonso‐Caneiro, David; Charng, Jason; Chen, Fred K.; Yazar, Seyhan; Mackey, David A.

doi:10.1167/tvst.10.3.8

Cited by 11 publications

(10 citation statements)

References 59 publications

(110 reference statements)

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“…To account for the intereye correlation of some patients, we performed a sensitivity analysis on the perioperative parameters by analyzing data with marginal linear regression models using generalized estimating equations (GEEs). 24 , 25 An exchangeable correlation structure was used in the models.…”

Section: Methodsmentioning

confidence: 99%

Three-Dimensional Heads-up Cataract Surgery Using Femtosecond Laser: Efficiency, Efficacy, Safety, and Medical Education—A Randomized Clinical Trial

Wang

Song

Zhang

et al. 2021

Trans. Vis. Sci. Tech.

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To compare the efficiency, efficacy, and safety, as well as the educational value, of heads-up (three-dimensional visualization system-assisted) and traditional microscopic cataract surgery.Methods: This randomized noninferiority trial enrolled 242 eyes of 201 patients who received femtosecond laser-assisted cataract surgery. The questionnaire study enrolled 26 medical interns and 39 medical students. Patients received surgery under either a three-dimensional visualization system (3D group, 117 eyes) or traditional microscope (TM group, 125 eyes) after random allocation. The primary outcome was surgical time. The noninferiority margin of surgical time was 60 seconds. Secondary outcomes included ultrasound power, phacoemulsification time, visual acuity, intraocular pressure, endothelial cell density, central corneal thickness, complications, and observer satisfaction scores for surgical procedures.Results: Surgical time was 462.03 ± 80.36 seconds in the 3D group and 452.13 ± 76.63 seconds in the TM group (difference 9.90 seconds; 95% CI, -9.98 to 29.78; P = 0.365). Visual acuity and other perioperative parameters were comparable between the 3D group and the TM group (all P > 0.05). Incidences of both intraoperative and postoperative complications were low and not statistically different between groups (all P > 0.05). Across all observers, 3D surgery was superior to TM surgery for improving the degree of satisfaction (all P < 0.001). Conclusions:The surgical efficiency of heads-up cataract surgery is not inferior to traditional microscopic surgery. Both methods achieved similar efficacy and safety outcomes. Moreover, heads-up cataract surgery showed a significant advantage in medical education.Translational Relevance: Our findings show that heads-up cataract surgery has comparable efficiency, efficacy, and safety, as well as superior medical educational value, to TM surgery, which lays the foundation for promoting and popularizing this technology.

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Section: Methodsmentioning

confidence: 99%

Three-Dimensional Heads-up Cataract Surgery Using Femtosecond Laser: Efficiency, Efficacy, Safety, and Medical Education—A Randomized Clinical Trial

Wang

Song

Zhang

et al. 2021

Trans. Vis. Sci. Tech.

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“…A Spectralis spectral-domain OCT (SD-OCT) was used to image the macula, with an axial and transverse resolution of 3.9 and 5.6 μm, respectively. Macular thicknesses of both eyes were obtained using a 31-line raster scan of 30° horizontal and 25° vertical area centred on the fovea [ 46 ], obtained using high-resolution mode and with “Automated Real Time (ART)” of 9 taken per raster scan. Prior to imaging, the corneal radius was entered into the instrument to correct for ocular magnification effects due to corneal curvature, as per the manufacturer’s protocol.…”

Section: Methodsmentioning

confidence: 99%

“…The raw SD-OCT scans were exported in E2E format using the built-in export function and analysed using a non-commercial custom program that was developed on MATLAB version R2017b (MathWorks, Inc. Natick, MA, USA) [ 46 ]. The transversal scaling (Scaling X) value for each eye, which differed between participants depending on the scan focus and corneal curvature adjustment, was extracted from the “image information” tab of the Heidelberg Eye Explorer.…”

Section: Methodsmentioning

confidence: 99%

“…To analyse the effect of correction in different refractive groups (myopes; spherical equivalent of ≤ -0.50D vs. non-myopes) [ 49 ], separate LMMs were generated with refractive groups (myopes and non-myopes) included in the models instead of axial length. Given retinal thickness is known to vary between sexes [ 50 ] and possibly ethnicities [ 51 , 52 ] these were adjusted for in the LMMs. Separate analyses were conducted for the Raine Study and K-YAMS cohorts to evaluate the agreeability between cohorts, as a sensitivity analysis.…”

Section: Methodsmentioning

confidence: 99%

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The effect of transverse ocular magnification adjustment on macular thickness profile in different refractive errors in community-based adults

et al. 2022

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Purpose Changes in retinal thickness are common in various ocular diseases. Transverse magnification due to differing ocular biometrics, in particular axial length, affects measurement of retinal thickness in different regions. This study evaluated the effect of axial length and refractive error on measured macular thickness in two community-based cohorts of healthy young adults. Methods A total of 2160 eyes of 1247 community-based participants (18–30 years; 23.4% myopes, mean axial length = 23.6mm) were included in this analysis. Macular thickness measurements were obtained using a spectral-domain optical coherence tomography (which assumes an axial length of 24.385mm). Using a custom program, retinal thickness data were extracted at the 9 Early Treatment of Diabetic Retinopathy Study (ETDRS) regions with and without correction for transverse magnificent effects, with the corrected measurements adjusting according to the participant’s axial length. Linear mixed models were used to analyse the effect of correction and its interaction with axial length or refractive group on retinal thickness. Results The raw measures (uncorrected for axial length) underestimated the true retinal thickness at the central macula, while overestimating at most non-central macular regions. There was an axial length by correction interaction effect in all but the nasal regions (all p<0.05). For each 1mm increase in axial length, the central macular thickness is overestimated by 2.7–2.9μm while thicknesses at other regions were underestimated by 0.2–4.1μm. Based on the raw thickness measurements, myopes have thinner retinas than non-myopes at most non-central macular. However, this difference was no longer significant when the corrected data was used. Conclusion In a community-based sample, the raw measurements underestimate the retinal thickness at the central macula and overestimate the retinal thickness at non-central regions of the ETDRS grid. The effect of axial length and refractive error on retinal thickness is reduced after correcting for transverse magnification effects resulting from axial length differences.

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“…In young adults, Lee et al [28] found no connection between axial length and other measures of retinal thickness in any macular areas.…”

Section: Discussionmentioning

confidence: 96%

Studying the Correlation between Axial Length and Retinal Nerve Fiber Layer and Macular Thickness by Spectral-Domain Optical Coherence Tomography

AL-Fatah

Habbak

Kamal

et al. 2021

Benha Journal of Applied Sciences

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Background: The ability to see well is critical in one's life. Our retina is similar to a film in a camera, generating electrical impulses that are then sent to the brain, where they are interpreted as visual pictures by retinal nerve fibres in the brain. A healthy macula provides the sharpest vision, which is essential for jobs that need a lot of visual processing power. To ensure the efficacy of treating macular injuries, it is essential to measure the thickness of the macula before and after therapy. Diagnostic imaging using OCT offers in vivo study of various retinal layers and anterior segment with 1-15 m resolution without contacting or invasively implanting any equipment into the patient's body Because it accurately measures RNFL and macular thickness and identifies early structural changes, it becomes an essential diagnostic tool for glaucoma, macular edoema, and other retinal and optic nerve disorders. It may also be used to follow up on patients with macular degeneration. It is now possible to create 3D pictures with unprecedented speed and quality thanks to the advent of the new SD-OCT technology. RNFL and macular thickness may be evaluated in a safe, consistent, rapid, and objective manner using this approach. Studying pRNFL and macular thickness in hyperopia, myopia, and emmetropia using spectral domain optical coherence tomography has the goal of learning how they relate to acuity levels (AL). Methods: The 45 eyes of 23 healthy volunteers were sorted into three categories based on their axial length: Group I (myopic) consists of 15 people (axial length: 24.6-27 mm). Eyes in the second group (Emmetropic) have (axial length: 22.6-24.5 mm). There are 15 eyes in this group that are hypermetropic (axial length: 20-22.5 mm). Spectral-domain Optical Coherence Tomography was utilised to quantify macular thickness and peripapillary RNFL thickness in all quadrates after a complete clinical examination of the participants. Results: To minimise the impact of age-related retinal changes, we structured the present research to include participants ranging in age from 14 to 40. Age had no effect on macular or pRNFL thickness, which were found to be identical. Our research identified no significant differences in macular thickness and RNFL thickness across other demographic characteristics including gender and eye preference. Because of this, these aspects aren't relevant when trying to determine what RNFL readings are typical. The research groups did not vary in central macular thickness (CMT). In all quadrants (temporal, inferior, and nasal), except in the superior quadrant, parafoveal thickness does not vary significantly. However, there was a strong negative association between it and other variables across research groups. There was a strong negative connection in the superior, temporal, and nasal quadrants for perifoveal thickness, but there was no difference in the inferior quadrant. This suggests that All quadrants had a thicker parafoveal zone than the perifoveal region. The "double hump pattern" and the "I...

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Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults

Cited by 11 publications

References 59 publications

Three-Dimensional Heads-up Cataract Surgery Using Femtosecond Laser: Efficiency, Efficacy, Safety, and Medical Education—A Randomized Clinical Trial

Three-Dimensional Heads-up Cataract Surgery Using Femtosecond Laser: Efficiency, Efficacy, Safety, and Medical Education—A Randomized Clinical Trial

The effect of transverse ocular magnification adjustment on macular thickness profile in different refractive errors in community-based adults

Studying the Correlation between Axial Length and Retinal Nerve Fiber Layer and Macular Thickness by Spectral-Domain Optical Coherence Tomography

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