Macular thickness measurements with frequency domain-OCT for quantification of axonal loss in chronic papilledema from pseudotumor cerebri syndrome

Monteiro, Mário Luiz Ribeiro; Afonso, Clara L.

doi:10.1038/eye.2013.301

Cited by 41 publications

(26 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Macular structures including GCL have not been well studied in IIH [16]. Reduced RNFL and GCL thicknesses are established abnormalities in multiple sclerosis (MS) [17].…”

Section: Discussionmentioning

confidence: 99%

OCT measurements of optic nerve head changes in idiopathic intracranial hypertension

Huang‐Link

Al-Hawasi

Oberwahrenbrock

et al. 2015

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

“…Macular structures including GCL have not been well studied in IIH [16]. Reduced RNFL and GCL thicknesses are established abnormalities in multiple sclerosis (MS) [17].…”

Section: Discussionmentioning

confidence: 99%

OCT measurements of optic nerve head changes in idiopathic intracranial hypertension

Huang‐Link

Al-Hawasi

Oberwahrenbrock

et al. 2015

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

“…Axonal loss is usually quantified by measuring OCT peripapillary retinal nerve fiber layer (RNFL) that allows an indirect estimation of RGC layer impairment. Furthermore, neuronal loss can be directly accessed by estimating macular thickness measurements, since 30–35 % of the retina thickness in macular area is composed by the RGCs and their fibers, as previously demonstrated in eyes with glaucoma, papilledema, compressive or demyelinating optic neuropathies [20–22]. If we take into account that the retina is considered a peripheral extension of the brain and both share similar embryological origin, it is easy to understand why OCT has become a widespread diagnostic tool in many neurological diseases.…”

Section: Introductionmentioning

confidence: 99%

The role of optical coherence tomography in Alzheimer’s disease

et al. 2016

View full text Add to dashboard Cite

BackgroundAlzheimer’s disease (AD) is the most common cause of dementia and its incidence is increasing worldwide along with population aging. Previous clinical and histologic studies suggest that the neurodegenerative process, which affects the brain, may also affect the retina of AD patients.Main bodyOptical coherence tomography (OCT) is a non-invasive technology that acquires cross-sectional images of retinal structures allowing neural fundus integrity assessment. Several previous studies demonstrated that both peripapillary retinal nerve fiber layer and macular thickness measurements assessed by OCT were able to detect neuronal loss in AD. Moreover, recent advances in OCT technology, have allowed substantial enhancement in ultrastructural evaluation of the macula, enabling the assessment not only of full-thickness retinal measurements but also of inner retinal layers, which seems to be a promising approach, mainly regarding the assessment of retinal ganglion cell layer impairment in AD patients. Furthermore, retinal neuronal loss seems to correlate with cognitive impairment in AD, reinforcing the promising role of OCT in the clinical evaluation of these patients.ConclusionThe purpose of this article is to review the main findings on OCT in AD patients, to discuss the role of this important diagnostic tool in these patients and how OCT technology may be useful in understanding morphological retinal changes in AD.

show abstract

“…At less extreme elevations, diseases such as idiopathic intracranial hypertension (IIH) and the spaceflight-related visual impairment intracranial pressure (VIIP) syndrome induce moderate, chronic visual changes (Acheson, 2006; Mader et al, 2011; Wall et al, 2014). In IIH, many patients also show evidence of optic nerve axon loss and RGC death (Keltner et al, 2014; Marzoli et al, 2013; Monteiro and Afonso, 2014; Padhye et al, 2013). Several reports have suggested that the balance between IOP and ICP is an important factor in optic neuropathies in general (Berdahl et al, 2008a; Berdahl et al, 2008b; Fleischman and Berdahl, 2014; Ren et al, 2010; Ren et al, 2011; Zhang and Hargens, 2014).…”

Section: Introductionmentioning

confidence: 99%

Elevated intracranial pressure causes optic nerve and retinal ganglion cell degeneration in mice

Nusbaum

Frankfort

2015

Experimental Eye Research

View full text Add to dashboard Cite

The purpose of this study was to develop a novel experimental system for the modulation and measurement of intracranial pressure (ICP), and to use this system to assess the impact of elevated ICP on the optic nerve and retinal ganglion cells (RGCs) in CD1 mice. This system involved surgical implantation of an infusion cannula and a radiowave based pressure monitoring probe through the skull and into the subarachnoid space. The infusion cannula was used to increase ICP, which was measured by the probe and transmitted to a nearby receiver. The system provided robust and consistent ICP waveforms, was well tolerated, and was stable over time. ICP was elevated to approximately 30 mmHg for one week, after which we assessed changes in optic nerve structure with transmission electron microscopy in cross section and RGC numbers with antibody staining in retinal flat mounts. ICP elevation resulted in optic nerve axonal loss and disorganization, as well as RGC soma loss. We conclude that the controlled manipulation of ICP in active, awake mice is possible, despite their small size. Furthermore, ICP elevation results in visual system phenotypes of optic nerve and RGC degeneration, suggesting that this model can be used to study the impact of ICP on the visual system. Potentially, this model can also be used to study the relationship between ICP and IOP, as well diseases impacted by ICP variation such as glaucoma, idiopathic intracranial hypertension, and the spaceflight-related visual impairment intracranial pressure syndrome.

show abstract

Macular thickness measurements with frequency domain-OCT for quantification of axonal loss in chronic papilledema from pseudotumor cerebri syndrome

Cited by 41 publications

References 36 publications

OCT measurements of optic nerve head changes in idiopathic intracranial hypertension

OCT measurements of optic nerve head changes in idiopathic intracranial hypertension

The role of optical coherence tomography in Alzheimer’s disease

Elevated intracranial pressure causes optic nerve and retinal ganglion cell degeneration in mice

Contact Info

Product

Resources

About