Macular Retinoschisis from Optic Disc without a Visible Optic Pit or Advanced Glaucomatous Cupping (No Optic Pit Retinoschisis [NOPIR])

Fujimoto, Satoko; Kokame, Gregg T.; Ryan, Edwin H.; Johnson, Mark W.; Hirakata, Akito; Shirriff, Ashley S; Ishikawa, Hiroshi; Adams, Olufemi E; Bommakanti, Nikhil

doi:10.1016/j.oret.2023.05.020

Cited by 7 publications

(1 citation statement)

References 35 publications

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“…SS-OCTA and en face SS-OCTA images reveal dark back shadowing in the superficial capillary plexus (SCP) or deep capillary plexus (DCP), depending on whether inner or outer retinal layers are involved, accompanied by a markedly increased reflectivity in the RNFL, where retinoschisis occurs ( 71 ). During the late phase of FA, no signs of leakage are observed in the peripapillary regions ( 76 ).…”

Section: Papillary/peripapillary Schisismentioning

confidence: 99%

Multimodal imaging of optic nerve head abnormalities in high myopia

Hu,

Wu,

et al. 2024

Front. Neurol.

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Highly myopic optic nerve head (ONH) abnormalities encompass a series of complications resulting from the stretching of papillary and peripapillary structures during significant axial elongation. The morphological changes in the ONH typically initiate with disk tilting or rotation, progressing to PHOMS and PPA. Tissue defects in each layer manifest as focal lamina cribrosa defects (FLDs), peripapillary intrachoroidal cavitations (PICCs), and acquired pits of the optic nerve (APON). Anterior vitreous/vascular traction and posterior scleral protrusion may lead to prelaminar schisis as well as paravascular cysts and holes, which can potentially develop into retinoschisis. Traditional color fundus photography (CFP) is often insufficient for visualizing most of these lesions, yet their description and quantification benefit significantly from the advancements in optical coherence tomography (OCT) and OCT angiography (OCTA), complemented by fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and three-dimensional imaging. The effective diagnosis and classification of ONH abnormalities heavily rely on a comprehensive understanding of their multimodal imaging features, as outlined in this review. These findings provide valuable insights into optic neuropathy in high myopia, establishing a solid foundation for future endeavors in disease monitoring and treatment guidance.

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Section: Papillary/peripapillary Schisismentioning

confidence: 99%