Macular perfusion velocities in the ocular ischaemic syndrome

Klefter, Oliver Niels; Kofoed, Peter Kristian; Munch, Inger Christine; Larsen, Michael

doi:10.1111/aos.13950

Cited by 2 publications

(2 citation statements)

References 25 publications

(22 reference statements)

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“…We postulate that this may be associated with decreased retinal blood perfusion caused by insufficient OA blood supply. 42 When ocular perfusion pressure decreases, the retinal arterial diameter initially increases by autoregulation. 43 However, the autoregulative capability of retinal vessels is limited.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome

Cheng,

Zhao,

Huang

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate the morphological characteristics of the ophthalmic artery (OA) and retinal vessels in ocular ischemic syndrome (OIS) and to compare their ability to identify OIS. Methods This cross-sectional observational study included 21 patients with unilateral OIS and 17 controls matched for age, sex, degree of internal carotid artery (ICA) stenosis, and cerebral collateral patency. This study used a three-dimensional reconstruction based on computed tomographic angiography to measure the morphological characteristics of the OA and the ICA. Quantitative measurements of retinal vessel diameter were performed using the Integrative Vessel Analysis software. Receiver operating characteristic (ROC) curve analysis was performed to assess the ability of the OA diameter and the central retinal artery equivalent (CRAE) to identify OIS. Results The diameter of the OA (odds ratio = 0.001; P = 0.001) and the CRAE (odds ratio = 0.951; P = 0.028) were significantly associated with the presence of OIS after adjusting for age, sex, and the degree of the ICA stenosis. The areas under the curve for the OA diameter and the CRAE were, respectively, 0.871 ( P < 0.001) and 0.744 ( P = 0.017) according to the ROC curves analysis. Conclusions The OA diameter measurement identified OIS better than CRAE measurement. The OA may reflect the changes in ocular blood supply in patients with OIS earlier than retinal vessels. The OA of eyes with OIS may undergo arterial wall remodeling, leading to a decrease in OA diameter and further reduction in blood flow.

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Section: Discussionmentioning

confidence: 99%

Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome

Cheng,

Zhao,

Huang

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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show abstract

“…Furthermore, bilateral common carotid artery occlusion model rats showed the perfusion of the eyes continued to reduced [ 26 ]. The macular perfusion velocities were markedly reduced in OIS eyes compared with unaffected fellow eyes and healthy controls [ 27 ]. Retinal blood vessels are auto-regulated.…”

Section: Discussionmentioning

confidence: 99%

Changes of retinal structure and function in patients with internal carotid artery stenosis

Wang

et al. 2022

BMC Ophthalmol

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Background To investigate the structural and functional changes of the retina in patients with different degrees of internal carotid artery (ICA) stenosis. Methods This cross-sectional study included patients with varying degrees ICA stenosis. Clinical characteristics of 41 patients were collected after being divided into four groups according to the ICA stenosis indicated by computed tomographic angiography (Group 0: without ICA stenosis, Group 1: ipsilateral slight ICA stenosis, Group 2: ipsilateral moderate ICA stenosis, Group 3: ipsilateral severe ICA stenosis). Retinal vessel caliber (RVC) was measured quantitatively with the Integrative Vessel Analysis software. The retinal sensitivity was examined with the MP-3 microperimeter. The relationships among central retinal artery equivalent (CRAE), central retinal vein equivalent, arteriole to venule ratio (AVR), mean retinal sensitivity (MS) and ICA stenosis degree were analysed. Results The CRAE in Group 3 were significantly smaller compared with Group 0, Group 1 and Group 2 (P < 0.001, P < 0.001, P = 0.002). Significant decrease was found between Group 3 with other groups in MS at fovea (P < 0.001, P < 0.001, P = 0.002). Moreover, there was a positive correlation found between MS and CRAE (Beta = 0.60, P < 0.001 at fovea; Beta = 0.64, P < 0.001 at 2 degree; Beta = 0.60, P < 0.001 at 4 degree; Beta = 0.55, P < 0.001 at 8 degree; Beta = 0.53, P < 0.001 at 12 degree). Conclusions The present study revealed smaller CRAE and AVR in ipsilateral severe ICA stenosis patients. And the MS decreased in patients with severe ICA stenosis. In addition, MS had a positive correlation with CRAE.

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Macular perfusion velocities in the ocular ischaemic syndrome

Cited by 2 publications

References 25 publications

Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome

Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome

Changes of retinal structure and function in patients with internal carotid artery stenosis

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