“…Clinical reports and small case series raised concern on potential side effects of the enzyme. These studies reported on clinical symptoms and findings including varying degrees of retinal dysfunction, such as visual acuity loss, dyschromatopsia, nyctalopia, visual field constriction, outer retinal signal abnormalities or defects on spectral domain optical coherence tomography, macular hole enlargement, macular detachment with subretinal fluid accumulation, and electroretinography changes [6,7,12,13,14,19,20,21,22,23,24,25]. …”