Macular Ganglion Cell/Inner Plexiform Layer Measurements by Spectral Domain Optical Coherence Tomography for Detection of Early Glaucoma and Comparison to Retinal Nerve Fiber Layer Measurements

Nouri‐Mahdavi, Kouros; Nowroozizadeh, Sara; Nassiri, Nariman; Cirineo, Nila; Knipping, Shane; Giaconi, JoAnn A.; Caprioli, Joseph

doi:10.1016/j.ajo.2013.08.001

Cited by 132 publications

(104 citation statements)

References 40 publications

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“…In our study, we found that the mean thicknesses of RNFL and GC-IPL in both the glaucoma groups were thinner, as expected, compared with the normal C group. These results are consistent with those of previous studies (27,28) . The CCT values were found to be significantly thinner in the NTG group than in the other groups (p<0.05).…”

Section: Discussionsupporting

confidence: 83%

“…Motion process and contrast sensitivity are parts of these visual processes (26) . In addition, ATD patients may have structural defects in the magnocellular visual pathway even in the absence of plaques and neurofibrillary tangles in these brain areas (27) . In our study, we found that the mean thicknesses of RNFL and GC-IPL in both the glaucoma groups were thinner, as expected, compared with the normal C group.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive performance of primary open-angle glaucoma and normal-tension glaucoma patients

Bulut¹,

Yaman²,

Erol³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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RESUMO Objetivos: Avaliar as diferenças de desempenho cognitivo entre pacientes com glau coma primário de ângulo aberto (POAG), glaucoma de pressão normal (NTG) e controle de indivíduos saudáveis (C).Métodos: Um total de 60 pessoas (20 POAG, 20 NTG e 20 85,2 ± 14,7, 76,8 ± 10,3 e 91,4 ± 7,7 µm nos grupos POAG, NTG e controles, respectivamente (p<0,001). As espessuras médias da GCIPL observadas foram 77.5 ± 9.7 μm no grupo POAG, 73,4 ± 7,8 ABSTRACTPurpose: To assess cognitive performance differences among primary open-angle glaucoma (POAG) patients, normal-tension glaucoma (NTG) patients, and healthy control (C) subjects. Methods: A total of 60 participants (20 POAG, 20 NTG, and 20 C subjects) were included in this study. A detailed ophthalmologic examination was performed on all participants. A spectral domain-optical coherence tomography (SD-OCT) system was used to measure the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) thicknesses. To assess the cognitive performance of all participants, detailed neurological examinations, including the mini-mental state examination (MMSE), were performed by the same neurologist. Results: There were no significant differences among the groups in terms of age (p=0.348) or gender (p=0.935). The mean RNFL thicknesses were significantly diffe rent among the groups (85.2 ± 14.7, 76.8 ± 10.3, and 91.4 ± 7.7 µm in the POAG, NTG, and C subjects, respectively; p<0.001). The mean GC-IPL thicknesses were 77.5 ± 9.7 µm in the POAG group, 73.4 ± 7.8 µm in the NTG group, and 78.8 ± 3.8 µm in the C group. Differences among the groups were not statistically significant (p=0.085). MMSE scores were 26.1 ± 1.4, 25.7 ± 2.3, and 28.8 ± 0.9 in the POAG, NTG, and C groups, respectively. There were significant differences among the three groups (p<0.001). Specifically, there were significant differences between the NTG and C groups (p<0.001), and between the POAG and C groups (p=0.001). There was no significant difference between the POAG and NTG groups (p=0.595). Conclusions: There appear to be similar risk factors in glaucoma and neurodegenerative disorders that cause deterioration in cognitive performance. Comparing the low MMSE scores of the POAG and NTG patients with the scores of healthy C participants supports our hypothesis. Consequently, it is recommended that a neurologist should also examine glaucoma patients.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Cognitive performance of primary open-angle glaucoma and normal-tension glaucoma patients

Bulut¹,

Yaman²,

Erol³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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“…These results are in agreement with the conclusion of Cennamo et al [20] that inferior GCC (AUC = 0.792) and mean GCC thickness (AUC = 0.742) are the best parameters to discriminate initial glaucomatous changes before the onset of VF losses. Other authors, however, have reported that average cpRNFL measurements are superior to global GCIPL measurements for the detection of early glaucoma, but regional GCIPL measurements (minimum and inferior temporal GCIPL) performed as well as regional cpRNFL measurements (inferior quadrant) [21] . This is consistent with the fact that the inferior rim is the most common site of glaucomatous damage [22] .…”

Section: Discussionmentioning

confidence: 93%

Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Severe Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes

Bambo

Güerri²,

Ferrández³

et al. 2017

Ophthalmic Res

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Objectives: To compare the circumpapillary retinal nerve fiber layer (cpRNFL) and the macular ganglion cell-inner plexiform layer (GCIPL) in glaucoma patients at different disease stages and to evaluate correlations between optical coherence tomography (OCT) parameters with central visual function and visual field (VF) indexes. Patients and Methods: One hundred forty patients were included in this prospective cross-sectional study. Subjects diagnosed with chronic open-angle glaucoma and 20/40 or better vision were recruited and classified as having early, moderate, or severe VF defects based on Hodapp-Parrish-Anderson criteria. cpRNFL and macular GCIPL were measured using Cirrus high-definition OCT. Central retinal sensitivity and visual acuity were recorded. Results: All OCT measurements differed significantly between patients with early and severe VF defects (p < 0.001). Correlations between central vision and VF indexes with OCT measurements were moderate but significant; better-correlated OCT parameters were the inferior cpRNFL quadrant, average cpRNFL thickness, inferior and inferior temporal GCIPL sectors, and minimum GCIPL thickness (r = 0.63-0.71, p < 0.001). Visual acuity was not correlated with either circumpapillary or macular OCT measurements. Conclusions: Inner macular parameters performed as well as cpRNFL in patients with different stages of glaucoma. Inferior macular GCIPL sectors, minimum GCIPL thickness, and the inferior cpRNFL quadrant best differentiate disease severity and correlate with central visual function and VF indexes.

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“…Several studies have shown SDOCT mGCC measurements to have similar ability to detect glaucoma as cpRNFL (Schulze et al, 2011;Tan et al, 2009), with similar findings also observed using mGCIPL measurements (Akashi et al, 2013;Jeoung et al, 2013;Kotowski et al, 2012;Mwanza et al, 2012;Nouri-Mahdavi et al, 2013). Mzanwa and colleagues recently demonstrated average mGCIPL thickness to have excellent ability to differentiate healthy and glaucomatous eyes, with an AUC of 0.935, which was almost identical to the AUC of cpRNFL of 0.936.…”

Section: Imaging the Maculamentioning

confidence: 55%

Strategies to improve early diagnosis in glaucoma

Tatham¹,

Medeiros²,

Zangwill³

et al. 2015

Progress in Brain Research

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Early diagnosis and treatment of glaucoma is important to reduce the risk of progressive and irreversible visual loss. The key to diagnosis is recognition of morphological changes to the optic nerve head and retinal nerve fiber layer, but in some patients, functional abnormalities are detected first. This review describes recent innovations with the potential to improve the early detection of glaucoma. Developments in imaging include novel optic nerve head metrics such as Bruch's membrane opening-minimum rim width, enhanced ability to quantify inner layers of the glaucomatous macula, and ability to image deep optic nerve head structures, including the lamina cribrosa. Developments in detection of early glaucomatous functional loss include novel perimetric tests using frequency-doubling technology and flicker-defined form stimuli. Methods to combine results of structural and functional assessments are also presented that may improve early detection of glaucoma. KeywordsGlaucoma, Optical coherence tomography, OCT, Perimetry, Spectral domain, Early diagnosis Glaucoma is a leading cause of blindness, affecting more than 70 million people worldwide, of whom approximately 10% are bilaterally blind (Quigley and Broman, 2006). Glaucomatous visual losses can be prevented with early diagnosis and treatment; however, affected individuals are typically asymptomatic until later stages of the disease and a large proportion of those affected remain undiagnosed. Population-level surveys suggest only 10-50% of people with glaucoma are aware that they have the condition and consequently there are a large number of people Progress in Brain Research, Volume 221, ISSN 0079-6123, http://dx

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Macular Ganglion Cell/Inner Plexiform Layer Measurements by Spectral Domain Optical Coherence Tomography for Detection of Early Glaucoma and Comparison to Retinal Nerve Fiber Layer Measurements

Cited by 132 publications

References 40 publications

Cognitive performance of primary open-angle glaucoma and normal-tension glaucoma patients

Cognitive performance of primary open-angle glaucoma and normal-tension glaucoma patients

Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Severe Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes

Strategies to improve early diagnosis in glaucoma

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