Macular Ganglion Cell and Retinal Nerve Fiber Layer Thickness in Children With Refractive Errors—An Optical Coherence Tomography Study

Abstract

This study establishes normative macular GC-IPL and RNFL thickness in children with refractive errors. Our results suggest that high definition optical coherence tomography RNFL parameters and minimum GC-IPL are not affected by AL or myopia in children, and therefore warrants further evaluation in pediatric glaucoma patients.

Assessment of macular ganglion cell complex using optical coherence tomography: Impact of a paediatric reference database in clinical practice

“…Inferior mRNFL and all GCL‐IPL parameters showed no significant correlation with age. As previous authors have reported, no relationship has been found between SE and mRNFL . Consistent with our results, Goh et al found a positive correlation between GCL‐IPL and SE in children, as did Zhao et al in their study with young Chinese people.…”

“…As previous authors have reported, no relationship has been found between SE and mRNFL. 8 Consistent with our results, Goh et al 8 found a positive correlation between GCL-IPL and SE in children, as did Zhao et al 29 in their study with young Chinese people. Nevertheless, Jin et al reported no differences in GCL-IPL between refractive groups and a negative correlation with age.…”

“…Macular ganglion cell‐inner plexiform layer thickness (GCL‐IPL) and macular retinal nerve fibre layer thickness (mRNFL) measurements, in particular, are potential markers for glaucoma and for progression of optic nerve and neurological diseases. The use of these parameters in children has been limited because of the paucity of normative databases …”

“…The use of these parameters in children has been limited because of the paucity of normative databases. 8 All OCT device software has an integrated normative database, which is limited to individuals aged 18 years or older. 9,10 No commercially available OCT device includes an age-normalised database for individuals younger than 18 years, thus limiting its application in paediatric patients.…”

Ganglion Cell Topography Indicates Pre- or Postnatal Damage to the Retro-Geniculate Visual System, Predicts Visual Field Function and May Identify Cerebral Visual Impairment in Children – A Multiple Case Study

“…They were examined with OCT ten or more years after the injury, at an age when age-related loss of ganglion cells is very small. [17][18][19] Fibre tractography of the OR lesions made it possible to localise and estimate the extent of the effect upon the retro-geniculate pathways, allowing for a topographical association Figure 1. Brain injury on MRI, visual field defects and GCL+IPL topography and layer thickness presentation for cases A-F. GW = gestational week, yrs = years, WMDI = white matter damage of immaturity, PCA = posterior cerebral artery, AVM = arteriovenous malformation, OR = optic radiation.…”