Macular Choroidal Neovascularization in Myopic Eyes After Phakic Intraocular Lens Implantation

Abstract

PURPOSE: To analyze the development and characteristics of choroidal neovascularization in highly myopic patients corrected by the implantation of phakic intraocular lenses (PIOLs). METHODS: This retrospective, noncomparative interventional case series studied the development of choroidal neovascularization in 522 consecutive highly myopic eyes (spherical equivalent refraction > -6.00 diopters [D] and/or axial length >26 mm) (323 patients) corrected by the implantation of PIOLs, the treatment performed, and the results obtained. Parameters evaluated were best spectacle-corrected visual acuity (BSCVA) before and after treatment of choroidal neovascularization, and the interval between refractive surgery and the development of choroidal neovascularization. RESULTS: Follow-up ranged from 12 to 145 months (mean: 60.4 ± 39.1 months). In 12 (2.29%) eyes, choroidal neovascularization developed after PIOL implantation at a mean interval time of 33.7 ± 29.6 months (range: 1 to 87 months). Using Kaplan-Meier analysis, the risk of choroidal neovascularization in patients with high myopia corrected by PIOL implantation was 0.57% at 5 months, 0.81% at 18 months, 1.31% at 24 months, and 3.72% at 87 to 145 months. No statistically significant differences were found between patients with and without choroidal neovascularization in the following parameters: axial length [P=.826), age (P=.296), initial BSCVA (P=.085), spherical equivalent refraction (P=.663), and follow-up (P=.955). CONCLUSIONS: Phakic intraocular lens implantation for the correction of high myopia does not play a role in the development of choroidal neovascularization. [J Refract Surg. 2006;22:689-694.]

Choroidal Neovascularization Following Implantation of Verisyse™ Iris- Supported Phakic Intraocular Lens in a Pregnant Myopic Patient

“…Time to development of CNV from implantation has been reported to range from 1-87 months with an average time of 33 months [6]. Choroidal neovascularization in pregnancy has also been reported to develop around the 6 th month of pregnancy [1, 2].…”

“…Choroidal neovascularization following correction of high myopia with phakic intraocular lenses has been reported to develop in 1.70% to 2.38% of patients [ 3 , 5 , 6 ]. Time to development of CNV from implantation has been reported to range from 1-87 months with an average time of 33 months [ 6 ]. Choroidal neovascularization in pregnancy has also been reported to develop around the 6 th month of pregnancy [ 1 , 2 ].…”

“…Another publication looked at the association between development of CNV and pregnancy [ 2 ]. There have also been case reports of CNV occurring in myopes receiving phakic intraocular lenses [ 3 - 6 ]. To our knowledge, no cases have reported CNV in a pregnant patient with the Verisyse™ (Abbott Medical Optics Inc. Abbott, IL, USA) iris-supported phakic intraocular lens (IOL).…”

Iris-Claw Phakic Anterior Chamber Lenses in Very High Myopia: A Three-Year Follow-up

“…Ruiz-Moreno ve ar-kadafllar› da yapt›klar› çal›flmada KNV geliflimi bildirilmifllerdir. Ancak çal›flmalar›nda fakik G‹M cerrahisinin KNV gelifliminde herhangi bir rol oynamad›¤› kan›s›na varm›fllard›r (26).…”