Macular and peripapillary retinal nerve fibre layer thickness in adults with amblyopia

Walker, Randy A.; Rubab, Shehla; Voll, Alexandra; Erraguntla, Vasudha; Murphy, Paul H.

doi:10.1016/j.jcjo.2011.07.013

Cited by 37 publications

(25 citation statements)

References 16 publications

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“…Few studies have used SD-OCT in amblyopia. Our group, using SD-OCT, reported an increased macular thickness in amblyopic eyes;11 however, Walker et al did not detect this difference 13. Park et al , using Spectralis SD-OCT, measured individual retinal layers in amblyopic eyes and reported thinning of the ganglion cell layer and inner plexiform layers 14.…”

Section: Introductionmentioning

confidence: 65%

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Macular ultrastructural features in amblyopia using high-definition optical coherence tomography

et al. 2012

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Section: Introductionmentioning

confidence: 65%

“…To date, few studies have examined amblyopic eyes using higher-resolution OCT technology 13 14. Most previous studies used the time domain modality.…”

Section: Discussionmentioning

confidence: 99%

Macular ultrastructural features in amblyopia using high-definition optical coherence tomography

et al. 2012

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“…In addition, most authors have reported similar fi ndings in previous studies. [17][18][19] Yoon et al reported that OCT assessment yielded a signifi cantly thicker RNFL thickness in patients with hyperopic anisometropic amblyopia. 10 Kee et al reported a signifi cantly thicker RNFL in anisometropic amblyopia than in strabismic amblyopia.…”

Section: Discussionmentioning

confidence: 99%

Macular and Retinal Nerve Fiber Layer Thickness in Unilateral Anisometropic or Strabismic Amblyopia

Andalib

Javadzadeh²,

Nabai³

et al. 2013

J Pediatr Ophthalmol Strabismus

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Purpose: To compare the macular and nerve fiber layer thicknesses as measured by optical coherence tomography (OCT) in amblyopic and fellow eyes. Methods: Fifty patients with monocular strabismic (n = 25) or anisometropic (n = 25) amblyopia (best corrected visual acuity (BCVA) ranging from 20/40 to 20/400) were included in a prospective cross-sectional descriptive study. A refractive error more than 5 diopters in either eye or an axial length difference between the eyes of more than 1 mm was excluded in the anisometropic group. In all cases, the thickness of the macular area and the peripapillary nerve fiber layer were measured by OCT in both amblyopic and fellow eyes and compared with each other. Results: The mean age of patients was 10 ± 3.1 years (range: 6 to 18 years) in the anisometropic group and 8.9 ± 3.7 years (range: 6 to 18 years) in the strabismic group. In the anisometropic group, the mean macular thickness was significantly increased in the amblyopic eyes (222.6 ± 47.8 μm) versus the fellow eyes (205.6 ± 33.3 μm) ( P = .002), although there was no significant difference observed when comparing with the prepapillary nerve fiber layer ( P = .55). There was no significant correlation of above-mentioned matters in the strabismic group ( P = .07 and .52). Conclusion: A thicker macula was found in anisometropic amblyopic eyes, but the increase of macular thickness in strabismic amblyopic eyes was not significant. Retinal involvement was not observed in the peripapillary nerve fiber layer of amblyopic eyes. [J Pediatr Ophthalmol Strabismus 2013;50(4):218–221.]

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“…Both the feline and primate models of amblyopia failed to reveal significant anatomical and physiological abnormalities in the retina of the amblyopic eye (Cleland et al, 1980, 1982). Similarly in humans, many studies have described the retina as essentially normal in amblyopes (Hess and Baker, 1984; Repka et al, 2009; Al-Haddad et al, 2011; Walker et al, 2011; Birch, 2013). At the next level of visual processing, in the lateral geniculate nucleus (LGN), minor changes were reported in the morphology of the cells (Guillery, 1973; Sloper et al, 1988; Sloper and Collins, 1998).…”

Section: Neural Correlates Of Amblyopiamentioning

confidence: 98%

Neuroimaging of amblyopia and binocular vision: a review

Joly

Frankó

2014

Front. Integr. Neurosci.

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Amblyopia is a cerebral visual impairment considered to derive from abnormal visual experience (e.g., strabismus, anisometropia). Amblyopia, first considered as a monocular disorder, is now often seen as a primarily binocular disorder resulting in more and more studies examining the binocular deficits in the patients. The neural mechanisms of amblyopia are not completely understood even though they have been investigated with electrophysiological recordings in animal models and more recently with neuroimaging techniques in humans. In this review, we summarize the current knowledge about the brain regions that underlie the visual deficits associated with amblyopia with a focus on binocular vision using functional magnetic resonance imaging. The first studies focused on abnormal responses in the primary and secondary visual areas whereas recent evidence shows that there are also deficits at higher levels of the visual pathways within the parieto-occipital and temporal cortices. These higher level areas are part of the cortical network involved in 3D vision from binocular cues. Therefore, reduced responses in these areas could be related to the impaired binocular vision in amblyopic patients. Promising new binocular treatments might at least partially correct the activation in these areas. Future neuroimaging experiments could help to characterize the brain response changes associated with these treatments and help devise them.

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Macular and peripapillary retinal nerve fibre layer thickness in adults with amblyopia

Cited by 37 publications

References 16 publications

Macular ultrastructural features in amblyopia using high-definition optical coherence tomography

Macular ultrastructural features in amblyopia using high-definition optical coherence tomography

Macular and Retinal Nerve Fiber Layer Thickness in Unilateral Anisometropic or Strabismic Amblyopia

Neuroimaging of amblyopia and binocular vision: a review

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