Macular and perimacular vascular remodelling sickling haemoglobinopathies.

Asdourian, George K.; Nagpal, Krishan C.; Busse, Bruce J.; Goldbaum, Michael H.; Patriankos, D; Rabb, Maurice F.; Goldberg, Morton F.

doi:10.1136/bjo.60.6.431

Cited by 79 publications

(40 citation statements)

References 21 publications

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“…Further, standard fundus-based clinical examination typically shows normal to minimal findings in the macular area in sickle cell patients [3]. Although patients are asymptomatic, many adult sickle cell patients do harbor findings of SCR that precede the clinical detection of a foveal depression sign [4], such as macular thinning measured by optical coherence tomography (OCT) [5] or vascular abnormalities in the macular region based on fluorescein angiography (FA) [6]. However, the existing techniques are limited in detecting subclinical signs of SCR.…”

Section: Introductionmentioning

confidence: 99%

Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography

Alam

Thapa

Lim

et al. 2017

Biomed. Opt. Express

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Abstract:Early detection is an essential step for effective intervention of sickle cell retinopathy (SCR). Emerging optical coherence tomography angiography (OCTA) provides excellent three-dimensional (3D) resolution to enable label-free, noninvasive visualization of retinal vascular structures, promising improved sensitivity in detecting SCR. However, quantitative analysis of SCR characteristics in OCTA images is yet to be established. In this study, we conducted comprehensive analysis of six OCTA parameters, including blood vessel tortuosity, vessel diameter, vessel perimeter index (VPI), area of foveal avascular zone (FAZ), contour irregularity of FAZ and parafoveal avascular density. Compared to traditional retinal thickness analysis, five of these six OCTA parameters show improved sensitivity for SCR detection than retinal thickness. It is observed that the most sensitive parameters were the contour irregularity of FAZ in the superficial layer and avascular density in temporal regions, while the area of FAZ, tortuosity and mean diameter of the vessel were moderately sensitive. E2395-E2402 (2015). 12. Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C. L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, and R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J.

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Section: Introductionmentioning

confidence: 99%

Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography

Alam

Thapa

Lim

et al. 2017

Biomed. Opt. Express

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“…In addition to the presence of an enlarged foveal avascular zone showing perifoveal capillary loss and nerve fiber layer infarcts, ano ther finding in sicklecell maculopathy is the formation of microaneurysmlike dots and vascular loops. These changes occur primarily in the nonperfused areas and do not cause leaking of fluorescein (26,28) . The incidence of acute symptoms caused by the presence of an averagesized arteriole occlusion in the macula is low.…”

Section: Macular Changesmentioning

confidence: 99%

“…In any case, the ischemic macular changes associated with sickle hemoglobinopathy are due to the occlusion of arteriolar circula tion around the foveal avascular zone and branches that supply the temporal horizontal raphe (6) . Those changes may or may not be associated with peripheral vascular occlusion and can occur in children (26) . layers could be demonstrated in patients with macular infarction (31) ; even without angiographic changes, this type of atrophy was de monstrated with spectral domain OCT (SDOCT) (32) .…”

Section: Macular Changesmentioning

confidence: 99%

Sickle cell retinopathy: diagnosis and treatment

Bonanomi

Lavezzo

2013

Arq. Bras. Oftalmol.

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Hemoglobinopathies are a group of inherited disorders characterized by quanti tative or qualitative malformations of hemoglobin (Hb). Some of these diseases present vasoocclusive phenomena that are responsible for high morbidity in clinical and/or ophthalmologic terms. Diagnosis of hemoglobinopathies is perfor med exclusively through hemoglobin electrophoresis. From the ophthalmologic perspective, the most important representative of this group of diseases is sickle cell retinopathy, which presents a wide spectrum of fundus manifestations and may even lead to irreversible vision loss if not properly diagnosed and treated. The aim of this review is to present the classification of sickle cell retinopathy and to describe current management and future perspectives for its treatment, taking into consideration the clinical management of these patients.

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“…Choroidal neovascularisation in age-related macular degeneration Smiddy et al [37] Occlusion of the carotid artery Wise [48], François et al [90], Carter [91], Jacobs and Ridgway [92] Central retinal vein obstruction and branch retinal vein obstruction Archer and Michalopoulos [93], Theodossiadis et al [94] Sarcoidosis Asdourian et al [42] Carotid-cavernous fistulas Kalina and Kelly [49], Harris et al [96] Oral contraceptives Jam polet al [59] Retinal detachment Tolentino et al [80] Cytomegalovirus retinitis Meredith et al [100] Birdshot retinochoroidopathy Barondes et al [65] Retinopathy of prematurity (retrolental fibroplasia)…”

Section: Acquired Diseasesmentioning

confidence: 99%

Retinal Telangiectasis and Proliferation of the Retinal Vessels in a Family

Schmidt¹,

Soriano²

1993

Ophthalmologica

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A 20-year-old woman presented with a marked proliferative retinopathy of the entire central region of the retina in both eyes, with veil-like epiretinal gliovascular membranes and isolated spots of haemorrhaging. The outer region of the retina was unremarkable. Her 49-year-old mother showed perimacular telangiectases in both eyes. The vascular system of both patients were medically sound, and, in particular, the blood pressure, blood sugar and blood picture were normal, with nc signs of heart, kidney, lung or liver disease. The first patienl had been a heavy smoker for 6 months, and the second did noi smoke. The 84-year-old mother of the second patient was blind following bilateral Horton’s temporal arteritis.

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Macular and perimacular vascular remodelling sickling haemoglobinopathies.

Cited by 79 publications

References 21 publications

Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography

Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography

Sickle cell retinopathy: diagnosis and treatment

Retinal Telangiectasis and Proliferation of the Retinal Vessels in a Family

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