Macular and Multifocal PERG and FD-OCT in Preperimetric and Hemifield Loss Glaucoma

Kreuz, André Carvalho; Moraes, Carlos Gustavo De; Hatanaka, Marcelo; Oyamada, Maria Kiyoko; Monteiro, Mário Luiz Ribeiro

doi:10.1097/ijg.0000000000000857

Cited by 13 publications

(7 citation statements)

References 54 publications

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“…There is compelling evidence to support the notion that the mfPERG response originates from activity of inner-retinal neurons and is likely generated at the optic nerve head [ 45 , 46 ]. While multiple studies have demonstrated the reduction of mfPERG amplitude in several disease conditions, its ability to detect focal defects as opposed to a generalised reduction may be disease specific [ 45 , 47 – 52 ].…”

Section: Electrophysiological Tests Of Optic Nerve and Retinal Ganglion Cell Functionmentioning

confidence: 99%

Clinical electrophysiology of the optic nerve and retinal ganglion cells

Marmoy

Viswanáthan

2021

Eye

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Clinical electrophysiological assessment of optic nerve and retinal ganglion cell function can be performed using the Pattern Electroretinogram (PERG), Visual Evoked Potential (VEP) and the Photopic Negative Response (PhNR) amongst other more specialised techniques. In this review, we describe these electrophysiological techniques and their application in diseases affecting the optic nerve and retinal ganglion cells with the exception of glaucoma. The disease groups discussed include hereditary, compressive, toxic/nutritional, traumatic, vascular, inflammatory and intracranial causes for optic nerve or retinal ganglion cell dysfunction. The benefits of objective, electrophysiological measurement of the retinal ganglion cells and optic nerve are discussed, as are their applications in clinical diagnosis of disease, determining prognosis, monitoring progression and response to novel therapies.

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Section: Electrophysiological Tests Of Optic Nerve and Retinal Ganglion Cell Functionmentioning

confidence: 99%

Clinical electrophysiology of the optic nerve and retinal ganglion cells

Marmoy

Viswanáthan

2021

Eye

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“…19 Thus, use of PERG has been proposed for evaluating SF relationship in some recent studies. Kreuz and coworkers 211 reported a significant correlation between the steadystate latency and P50 peak time on PERG and macular RNFL thickness. This finding was confirmed by Park and coworkers 305 who showed that a linear regression model (r 2 = 0.22) best fitted the relationship between N95 amplitude on PERG and GCIPL thickness.…”

Section: Relationship Of Macular Parameters and Other Functional Measures-a Fewmentioning

confidence: 96%

Macular imaging with optical coherence tomography in glaucoma

Mohammadzadeh

Fatehi

Yarmohammadi

et al. 2020

Survey of Ophthalmology

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“…5,6 Several studies have used variants of the pattern electroretinogram (PERG), a sensitive measure of RGC function, [7][8][9] to investigate local responses in healthy and diseased central retina. [10][11][12][13][14][15][16][17][18][19][20][21] It is still not well-established whether the magnitude of the PERG signal reflects the magnitude of RGC density at multiple locations, whether PERG latency reflects the conduction time of intraretinal axons, and whether local PERGs have unique features that may provide clues on regional RGC vulnerability in optic nerve disease, such as glaucoma and optic neuritis.…”

Section: Introductionmentioning

confidence: 99%

Compartmental Differences in Macular Retinal Ganglion Cell Function

Alba

Huang

Roghaee

et al. 2021

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study was to investigate local differences of macular retinal ganglion cell (RGC) function by means of the steady-state pattern electroretinogram (SS-PERG). Methods SS-PERGs were recorded in healthy subjects ( n = 43) in response to gratings (1.6 c/deg, 15.63 reversals/s, and 98% contrast) presented on an LED display (800 cd/m 2 , 12.5 degrees eccentricity at 30 cm viewing distance) partitioned in triangular sectors (inferior [I]; nasal [N]; superior [S]; and temporal [T]) or concentric regions (central [C] and annulus [A]). For each partition, response amplitude (nV), amplitude adaptation (% change over recording time), phase/latency (deg/ms), and oscillatory potentials (OPs) amplitude (root mean square [RMS] nV) were measured. Data were analyzed with Generalized Estimating Equation (GEE) statistics. Results Amplitude differed ( P < 0.001) between sectors (I: 254 nV; N: 328 nV; S: 275 nV; T: 264 nV; and N>T, I) as well as concentrically (C: 684 nV; A: 323 nV; and C>A). Latency did not differ between sectors (range = 53–54 ms, P = 0.45) or concentrically (range = 51–51 ms, P = 0.7). Adaptation did not differ ( P = 0.66) concentrically (C: −19% and A: −22%) but differed ( P = 0.004) between sectors (I: +25% and S: −29%). The OP amplitude did not differ ( P = 0.5) between sectors (range = 63–73 nV) as well as concentrically (range = 82–90 nV, P = 0.3). Conclusions Amplitude profiles paralleled RGC densities from histological studies. Adaptation profile suggested greater autoregulatory challenge in the inferior retina. Latency profile may reflect axonal conduction time to the optic nerve head assuming a direct relationship between axon length and its size/velocity. Location-independent OPs may reflect preganglionic activity. Translational Relevance Normal macular RGC function displays local differences that may be related to local vulnerability in optic nerve disorders.

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Macular and Multifocal PERG and FD-OCT in Preperimetric and Hemifield Loss Glaucoma

Abstract: PERG and OCT parameters may be abnormal, with significant correlations between measurements, in PG eyes. Both technologies may be useful for detection of early glaucoma.

Cited by 13 publications

References 54 publications

Clinical electrophysiology of the optic nerve and retinal ganglion cells

Clinical electrophysiology of the optic nerve and retinal ganglion cells

Macular imaging with optical coherence tomography in glaucoma

Compartmental Differences in Macular Retinal Ganglion Cell Function

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