Macula and optic disk features in methamphetamine and crystal methamphetamine addicts using optical coherence tomography

Mahjoob, Monireh; Maleki, Alireza; Askarizadeh, Farshad; Heydarian, Samira; Rakhshandadi, Tahereh

doi:10.1007/s10792-021-02200-6

Cited by 5 publications

(8 citation statements)

References 31 publications

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“…Our subjects all had BCVA <0.2 LogMAR and those with retinal diseases were excluded. Nevertheless, OCT results published elsewhere 21,23 have indicated a significant decrease in the retinal thickness of the perifoveal region as well as the thickness of the superior and temporal regions of the retinal nerve fibre layer (that are highly correlated with the macula) among methamphetamine users. This confirms the presence of subclinical structural changes in the retina.…”

Section: Discussionmentioning

confidence: 99%

“…The retinal structure of all subjects (macular thickness, nerve fibre thickness and optic nerve head parameters) was assessed using Fourier-domain optical coherence tomography (OCT) (Optovue, RTVue, oct-optov ue.com) as described in a previous report. 21 Monocular pattern-reversal VEPs were recorded using the Roland RETI system (RETI, rolan d-consu lt.de/) in a dark room following 20 min of dark adaptation, using the instructions provided by the International Society for Clinical Electrophysiology of Vision. 22 Stimuli included highcontrast (99%) checkerboard patterns subtending 15 and 60 min of arc, which were reversed at a rate of 1.53 reversals per second.…”

Section: Methodsmentioning

confidence: 99%

“…The control group had no history of smoking, psychostimulant drug use, drug dependency, alcohol consumption or systemic drug use. The retinal structure of all subjects (macular thickness, nerve fibre thickness and optic nerve head parameters) was assessed using Fourier‐domain optical coherence tomography (OCT) (Optovue, RTVue, http://oct-optovue.com) as described in a previous report 21 …”

Section: Methodsmentioning

confidence: 99%

“…In line with our findings, no significant relationship has been found between VEP components and RNFL thickness in diseases, which cause a significant reduction in RNFL thickness. [33][34][35] Besides the reduction in retinal thickness and RNFL thickness in methamphetamine users, 21 neuroimaging shows the toxic effects of this drug. Indeed, it can alter several brain structures by damaging dopamine and serotonin axons and causing a loss of grey matter.…”

Section: Amplitude Of P100-n135 (μV)mentioning

confidence: 99%

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Long‐term effects of methamphetamine abuse on visual evoked potentials

Mahjoob

Heydarian

2022

Ophthalmic Physiologic Optic

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Purpose To compare visual evoked potential (VEP) components in normal individuals and those with long‐term methamphetamine and crystal methamphetamine use. Methods In this study, monocular pattern‐reversal VEPs were recorded in 40 methamphetamine and crystal methamphetamine users and 38 normal individuals. Visual stimuli were high‐contrast (99%) checkerboard patterns at 15 and 60 min of arc with a reversal rate of 1.53 reversals per second. Results A significant difference was seen between the two groups for the P100 peak time for the 60 min of arc checks (p = 0.002, d = 0.75, 4.61% higher peak time in the addicted group) and the 15 min of arc checks (p = 0.004, d = 0.73, 4.78% higher peak time in the addicted group). However, other VEP components were not significantly different between the two groups. Conclusions The higher P100 peak time at both 15 and 60 min of arc in methamphetamine‐dependent users reveals that VEPs are highly sensitive for the diagnosis of retinal and visual pathway lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Amplitude Of P100-n135 (μV)mentioning

confidence: 99%

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Long‐term effects of methamphetamine abuse on visual evoked potentials

Mahjoob

Heydarian

2022

Ophthalmic Physiologic Optic

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“…In one of the other studies that were conducted with MUD patients, no difference was detected between patients and healthy controls. In one patient group, minimal thinning was found in the superior and temporal quadrants [ 16 , 26 ]. In an animal study that considered three groups of mice (mice injected with a high or low dose of methamphetamine, as well as healthy mice), it was shown that increased chemokines resulted in damage to the retina in the mouse group injected with high-dose methamphetamine [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

OCT Findings in Patients with Methamphetamine Use Disorder

Kaya

Kaya²

2023

JPM

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Purpose: In the present study, the purpose was to examine the results of optical coherence tomography (OCT) measurements in patients diagnosed with methamphetamine use disorder (MUD) by comparing them with healthy controls. Materials and Methods: A total of 114 eyes were evaluated in this study (27 patients and 30 control group participants). After detailed biomicroscopic examinations of all participants by the same ophthalmologist, both eyes were evaluated by OCT. The retinal nerve fiber layer thickness (RNFL) and macular thickness were calculated from OCT. Results: No statistically significant differences were detected between the demographic data of the patient and control groups (p > 0.05). When OCT findings were evaluated, macular thickness and volume were not different between the groups (p > 0.05). With respect to RNFL, the left eye superior, inferior, temporal, and nasal quadrants, as well as the left eye’s total measurements were found to be thicker than those of controls (p < 0.05). In both eyes, the left eye nasal quadrant and APIS total score were negatively correlated, the total RNLF measurement of the right eye and APIS motivation subscale score were negatively correlated, central macular thickness and the APIS motivation subscale score were positively correlated, and the APIS substance use characteristics subscale score and left eye temporal quadrant RNLF measurement were positively correlated. Conclusion: Our study is the first to evaluate addiction severity and OCT findings in MUD. However, this study needs to be supported by further studies so that OCT findings, which can be used as an effective method for demonstrating possible neurodegeneration in methamphetamine use disorder, gain importance.

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